1 research outputs found
Circadian rhythm modulation of microbes during health and infection
Circadian rhythms, referring to 24-h daily oscillations in biological and physiological
processes, can significantly regulate host immunity to pathogens, as well as
commensals, resulting in altered susceptibility to disease development. Furthermore,
vaccination responses to microbes have also shown time-of-day-dependent changes in
the magnitude of protective immune responses elicited in the host. Thus, understanding
host circadian rhythm effects on both gut bacteria and viruses during infection is
important to minimize adverse effects on health and identify optimal times for therapeutic
administration to maximize therapeutic success. In this review, we summarize the
circadian modulations of gut bacteria, viruses and their interactions, both in health
and during infection. We also discuss the importance of chronotherapy (i.e., timespecific therapy) as a plausible therapeutic administration strategy to enhance beneficial
therapeutic responses