28 research outputs found
Mitochondrial abnormalities-A link to idiosyncratic drug hepatotoxicity?
10.1016/j.taap.2006.12.013Toxicology and Applied Pharmacology220192-10
Troglitazone-induced hepatic necrosis in an animal model of silent genetic mitochondrial abnormalities
10.1093/toxsci/kfl180Toxicological Sciences971205-21
Troglitazone-induced hepatic mitochondrial proteome expression dynamics in heterozygous Sod2+/-mice: Two-stage oxidative injury
Toxicology and Applied Pharmacology231143-51TXAP
Critical role of free cytosolic calcium, but not uncoupling, in mitochondrial permeability transition and cell death induced by diclofenac oxidative metabolites in immortalized human hepatocytes
10.1016/j.taap.2006.09.012Toxicology and Applied Pharmacology2173322-33
The mitochondrial superoxide/thioredoxin-2/ask1 signaling pathway is critically involved in troglitazone-induced cell injury to human hepatocytes
10.1093/toxsci/kfm273Toxicological Sciences1012341-349TOSC
Oxidative bioactivation and toxicity of leflunomide in immortalized human hepatocytes and kinetics of the non-enzymatic conversion to its major metabolite, A77 1726
10.2174/187231208785425791Drug Metabolism Letters23153-15
Acetaminophen Produces Cataract in DBA2 Mice by Ah Receptor-Independent Induction of CYP1A2
Nimesulide-induced hepatic mitochondrial injury in heterozygous Sod2+/-mice
10.1016/j.freeradbiomed.2005.08.038Free Radical Biology and Medicine403420-42
Mitochondrial permeability transition as a source of superoxide anion induced by the nitroaromatic drug nimesulide in vitro
10.1016/j.freeradbiomed.2005.05.013Free Radical Biology and Medicine397949-95