Explaining two circumnuclear star forming rings in NGC5248

The distribution of gas in the central kiloparsec of a galaxy has a dynamically rapid evolution. Nonaxisymmetries in the gravitational potential of the galactic disk, such as a large scale stellar bar or spiral, can lead to significant radial motion of gaseous material from larger radii to the central region. The large influx of gas and the subsequent star formation keep the central region constantly changing. However, the ability of gas to reach the nucleus proper to fuel an AGN phase is not guaranteed. Gas inflow can be halted at a circumnuclear star forming ring several hundred parsec away. The nearby galaxy NGC5248 is especially interesting in this sense since it is said to host 2 circumnuclear star forming rings at 100pc and 370pc from its quiescent nucleus. Here we present new subarcsecond PdBI+30m CO(2-1) emission line observations of the central region. For the first time the molecular gas distribution at the smallest stellar ring is resolved into a gas ring, consistent with the presence of a quiescent nucleus. However, the molecular gas shows no ring structure at the larger ring. We combine analyses of the gaseous and stellar content in the central kiloparsec of this galaxy to understand the gas distribution and dynamics of this star forming central region. We discuss the probability of two scenarios leading to the current observations, given our full understanding of this system, and discuss whether there are really two circumnuclear star forming rings in this galaxy.Comment: Accepted for publication in A&A, 14pages + long tabl

Neural correlates of ‘pessimistic' attitude in depression

Background Preparing for potentially threatening events in the future is essential for survival. Anticipating the future to be unpleasant is also a cognitive key feature of depression. We hypothesized that ‘pessimism'-related emotion processing would characterize brain activity in major depression. Method During functional magnetic resonance imaging, depressed patients and a healthy control group were cued to expect and then perceive pictures of known emotional valences - pleasant, unpleasant and neutral - and stimuli of unknown valence that could have been either pleasant or unpleasant. Brain activation associated with the ‘unknown' expectation was compared with the ‘known' expectation conditions. Results While anticipating pictures of unknown valence, activation patterns in depressed patients within the medial and dorsolateral prefrontal areas, inferior frontal gyrus, insula and medial thalamus were similar to activations associated with expecting unpleasant pictures, but not with expecting positive pictures. The activity within a majority of these areas correlated with the depression scores. Differences between healthy and depressed persons were found particularly for medial and dorsolateral prefrontal and insular activations. Conclusions Brain activation in depression during expecting events of unknown emotional valence was comparable with activation while expecting certainly negative, but not positive events. This neurobiological finding is consistent with cognitive models supposing that depressed patients develop a ‘pessimistic' attitude towards events with an unknown emotional meaning. Thereby, particularly the role of brain areas associated with the processing of cognitive and executive control and of the internal state is emphasized in contributing to major depressio

The ontology of biological taxa

Motivation: The classification of biological entities in terms of species and taxa is an important endeavor in biology. Although a large amount of statements encoded in current biomedical ontologies is taxon-dependent there is no obvious or standard way for introducing taxon information into an integrative ontology architecture, supposedly because of ongoing controversies about the ontological nature of species and taxa

Ketamine decreases resting state functional connectivity between networks via the dorsal nexus: implications for major depression

Question: Increasing preclinical and clinical evidence underscores the strong and rapid antidepressant properties of the glutamate modulating NMDA receptor antagonist ketamine [1, 2]. Targeting the glutamatergic system might thus provide a novel therapeutic strategy for antidepressant drug treatment [3]. Since glutamate is the most abundand and major excitatory neurotransmitter in the human brain, pathophysiological changes in glutamatergic signalling are likely to affect neurobehavioural plasticity, information processing and large-scale changes in functional brain connectivity underlying certain symptoms of major depressive disorder (MDD) [4]. Using resting state functional MRI (rsfMRI), the „dorsal nexus“ (DN) was recently identified as a bilateral dorsal medial prefrontal cortex (DMPFC) region showing dramatically increased depression-associated fMRI connectivity with large portions of the cognitive control network (CCN), the default mode network (DMN), and the affective network (AN) [5]. Hence, Sheline and colleagues [5] proposed that reducing increased connectivity of the DN might play a critical role in reducing depressive symptomatology and thus represent a potential therapeutic target for affective disorders. Since little is known about how ketamine affects large-scale neural network dynamics in the human brain, we aimed to test the hypothesis that ketamine as an antidepressant glutamatergic agent decreases resting state connectivties via the DN. Methods: Study design: 17 healthy subjects (mean age, 40.5 +/- 7.5 [SD]; 9 males) completed four resting state fMRI sessions in a double-blind, randomized, crossover study design (s. Fig 1). The baseline scan was followed by an intravenous infusion (45 mins) of either S-ketamine (0.25 mg/kg) or placebo (saline) outside the scanner. Since the antidepressant effect of ketamine is most prominent after one day [1], the followup scans were scheduled 24 hours after the ketamine or placebo infusion in order to assess the mid-term effects on neuronal network dynamics that might contribute to its antidepressant efficacy. To avoid a possible carry-over effect, the time lag between the two baseline measurements was set to at least 10 days. rsfMRI data acquisition and analysis: Measurements were performed on a Philips Achieva TX 3-T whole-body MR unit equipped with an 8-channel SENSE head coil. During each session a total of 200 functional images were collected in 10 minute runs (eyes closed) using the following acquisition parameters: TE = 35 ms, TR = 3000 ms (θ = 82°), FOV = 22 cm, acquisition matrix = 80 x 80 interpolated to 128 x 128, voxel size = 2.75 x 2.75 x 4 mm, 32 contiguous axial slices (placed along the anterior-posterior commissure plane), and sensitivity-encoded acceleration factor R = 2.0. A 3-dimensional T1-weighted anatomical scan was obtained for structural reference. Data were analyzed using the SPM8 (Wellcome Trust Center for Neuroimaging, London, England) based data processing assistant for resting state fMRI (DPARSF, by Yan Chao-Gan et al.) which includes a resting state fMRI data analysis toolkit (REST, by Song Xiao-Wei et al.). The postprocessing steps followed the standard protocol described by Yan and Zang (2010) [6]. Results: To test our hypothesis, we created a seed region of interest in the left and right DMPFC (10 mm sphere at ± 6 51 24) representing the DN. 24 h following ketamine administration, functional connectivity was exclusively reduced to the posterior cingulate cortex (PCC), to the subgenual anterior cingulate cortex (sgACC), and to anterior and mediodorsal parts of the thalamus (compared to placebo). The backprojection from a seed in the PCC confirmed these results and revealed an additional significant reduction of functional connectivity to the pregenual ACC (PACC) and medioprefrontal cortex (MPFC). For details, see Fig. 2 A, B and bar diagrams (functional connectivity change, paired t tests). Conclusion: While pharmacological effects of ketamine on task induced fMRI BOLD signals have been studied extensively, this is the first randomized, placebo-controlled, double-blind, crossover study demonstrating changes in resting state functional connectivity in response to ketamine administration in healthy subjects. Here, we report a significant decrease in functional connectivity of the sgACC (AN) and the PCC (DMN) via the DN 24 hours following ketamine administration, thus reflecting a neuronal pattern of normalization with regard to MDD where increased connectivities of the AN and DMN via the DN have been observed [5]. As critical hub of the AN, the sgACC plays an important role in mood regulation. Subgenual cortical activity was shown to be elevated in MDD and effective antidepressant treatment was associated with a reduction in sgACC activity [for review see ref. 7]. In addition, the observed reduction in functional connectivity between anterior (PACC/MPFC) and posterior parts of the DMN (PCC) may partially reverse the disrupted neurobehavioral homeostasis in MDD where a failure to normally down-regulate activity within the DMN during emotional stimulation was found [8], with increasing levels of DMN dominance being associated with higher levels of maladaptive, depressive rumination and lower levels of adaptive, reflective rumination [9]. Finally, reductions in cortico-thalamic connectivity may reflect functional alterations in thalamocortical loops via the prefrontal cortex. Based on the fact that the antidepressant effect of ketamine peaks one day after a single intravenous administration [1], we conclude that pharmacologically reducing the hyperconnectivity via the DN may play a critical role in reducing depressive symptomatology and in representing a systems level mechanism of treatment response for major depression

HST/WFPC2 imaging of the circumnuclear structure of LLAGNs. I Data and nuclear morphology

To advance our knowledge of the nature of the central source in LLAGNs and its relation with stellar clusters, we are carrying out several imaging projects with HST at near-UV, optical and near-IR wavelengths. In this paper, we present the first results obtained with observations of the central regions of 57 LLAGNs imaged with the WFPC2 through any of the V (F555W, F547M, F614W) and I (F791W, F814W) filters that are available in the HST archive. The sample contains 34% of the LINERs and 36% of the TOs in the Palomar sample. The mean spatial resolution of these images is 10 pc. With these data we have built an atlas that includes structural maps for all the galaxies, useful to identify compact nuclear sources and, additionally, to characterize the circumnuclear environment of LLAGNs, determining the frequency of dust and its morphology. The main results obtained are: 1) We have not found any correlation between the presence of nuclear compact sources and emission-line type. Thus, nucleated LINERs are as frequent as nucleated TOs. 2) The nuclei of "Young-TOs" are brighter than the nuclei of "Old-TOs" and LINERs. These results confirm our previous results that Young-TOs are separated from other LLAGNs classes in terms of their central stellar population properties and brightness. 3) Circumnuclear dust is detected in 88% of the LLAGNs, being almost ubiquitous in TOs. 4) The dust morphology is complex and varied, from nuclear spiral lanes to chaotic filaments and nuclear disk-like structures. Chaotic filaments are as frequent as dust spirals; but nuclear disks are mainly seen in LINERs. These results suggest an evolutionary sequence of the dust in LLAGNs, LINERs being the more evolved systems and Young-TOs the youngest. The full collection of figures are at http://www.iaa.es/~rosa/research/LLAGNs2007/LLAGNs-HSTIma1.htmlComment: Paper accepted in AJ, pdf file and the full collection of figures are at the ULR: http://www.iaa.es/~rosa/research/LLAGNs2007/LLAGNs-HSTIma1.htm

Gender and rapid alterations of hemispheric dominance during planning

BACKGROUND: Mental planning and carrying out a plan provoke specific cerebral hemodynamic responses. Gender aspects of hemispheric laterality using rapid cerebral hemodynamics have not been reported. METHOD: Here, we applied functional transcranial Doppler sonography to examine lateralization of cerebral hemodynamics of the middle cerebral arteries of 28 subjects (14 women and 14 men) performing a standard planning task. There were easy and difficult problems, and mental planning without motor activity was separated from movement execution. RESULTS: Difficult mental planning elicited lateralization to the right hemisphere after 2 or more seconds, a feature that was not observed during movement execution. In females, there was a dominance to the left hemisphere during movement execution. Optimized problem solving yielded an increased laterality change to the right during mental planning. CONCLUSIONS: Gender-related hemispheric dominance appears to be condition-dependent, and change of laterality to the right may play a role in optimized performance. Results are of relevance when considering laterality from a perspective of performance enhancement of higher cognitive functions, and also of psychiatric disorders with cognitive dysfunctions and abnormal lateralization patterns such as schizophrenia

NIRSpec, The Near-ir Multi-object Spectrograph For JWST

NIRSpec will be the first slit-based astronomical multi-object spectrograph to fly in space, and is designed to provide spectra of faint objects over the near-infrared 1.0 - 5.0 micron wavelength range at spectral resolutions of R=100, R=1000 and R=2700. The instrument's all-reflective wide-field optics, together with its novel MEMS-based programmable micro-shutter array slit selection device and its large format low-noise HgCdTe detector arrays, combine to allow simultaneous observations of >100 objects within a 3.4 x 3.5 arcmin field of view with unprecedented sensitivity. A selectable 3 x 3 arcsec Integral Field Unit and five fixed slits are also available for detailed spectroscopic studies of single objects. NIRSpec is being built for the European Space Agency (ESA) by EADS Astrium as part of ESA's contribution to the JWST mission. The NIRSpec micro-shutter and detector arrays are provided by NASA/GSFC

Extrapolating SMBH correlations down the mass scale: the case for IMBHs in globular clusters

Empirical evidence for both stellar mass black holes M_bh<10^2 M_sun) and supermassive black holes (SMBHs, M_bh>10^5 M_sun) is well established. Moreover, every galaxy with a bulge appears to host a SMBH, whose mass is correlated with the bulge mass, and even more strongly with the central stellar velocity dispersion sigma_c, the `M-sigma' relation. On the other hand, evidence for "intermediate-mass" black holes (IMBHs, with masses in the range 1^2 - 10^5 M_sun) is relatively sparse, with only a few mass measurements reported in globular clusters (GCs), dwarf galaxies and low-mass AGNs. We explore the question of whether globular clusters extend the M-sigma relationship for galaxies to lower black hole masses and find that available data for globular clusters are consistent with the extrapolation of this relationship. We use this extrapolated M-sigma relationship to predict the putative black hole masses of those globular clusters where existence of central IMBH was proposed. We discuss how globular clusters can be used as a constraint on theories making specific predictions for the low-mass end of the M-sigma relation.Comment: 14 pages, 3 figures, accepted for publication in Astrophysics and Space Science; fixed typos and a quote in Sec.

Mitigation of Moral Hazard and Adverse Selection in Venture Capital Financing: The Influence of the Country’s Institutional Setting

A venture capitalist (VC) needs to trade off benefits and costs when attempting to mitigate agency problems in their investor-investee relationship. We argue that signals of ventures complement the VC’s capacity to screen and conduct a due diligence during the pre-investment phase, but its attractiveness may diminish in institutional settings supporting greater transparency. Similarly, whereas a VC may opt for contractual covenants to curb potential opportunism by ventures in the post-investment phase, this may only be effective in settings supportive of shareholder rights enforcement. Using an international sample of VC contracts, our study finds broad support for these conjectures. It delineates theoretical and practical implications for how investors can best deploy their capital in different institutional settings whilst nurturing their relationships with entrepreneurs