The application of manganese(VI) and copper(III) in strongly alkaline solutions as strong oxidizing reagents in flow injection analysis is described. Both reagents were prepared under batch conditions and fed to the flow from a stock solution. The reactions of most analytes tested with manganese(VI) required the use of a heated (65° C) reaction coil. The main application appears to be for the determination of monosaccharides in the 10−4–10−5 mol l−1 range