Mucinous adenocarcinoma of stomach with multiple foci of calcification: Addition of a case and a review of literature

In gastric carcinoma, tissue calcification is rarely noted. Most of the adenocarcinoma cases with calcification described in literature are gastric mucinous adenocarcinoma. We present one such case of a 33-year-old female with a brief review of literature. The multiple foci of punctate calcification were visible in images, gross specimen, and also on histopathological examination. This is an addition of a case to the existing literature

Giant cell tumor of tendon sheath in palmar region-cytological aspect of an uncommon tumor

Giant cell tumor of tendon sheath (GCTTS) is a benign soft tissue neoplasm. It is the second most common tumor of the hand after ganglion. The pathogenesis of GCTTS is not known. This tumor is known to recur after excision. We present a case of GCTTS in the palmar aspect of the right hand of a 41-year-old female. Ultrasonography of hand revealed a well-defined hypoechoic lesion in the subcutaneous plane with focal areas of calcification. She underwent fine-needle aspiration (FNA). The FNA smears showed the characteristic presence of stromal cells and multinucleated osteoclast-like giant cells. This is an uncommon case of GCTTS present in the palmar aspect of hand diagnosed by FNA

Rare case of blastemal predominant adult Wilms′ tumor with skeletal metastasis case report and brief review of literature

Wilms′ tumor (nephroblastoma) is extremely rare in adults, skeletal metastasis being still rarer. The clinical course of adult Wilms′ tumor is very aggressive. The present case is a rare blastemal predominant adult Wilms′ tumor presenting with skeletal metastasis. We report a case of 19-year-old female presented with severe low backache and colicky left loin pain of 3 months and progressive weakness of 15 days duration. Magnetic resonance image (MRI) of lumbosacral spine was reported as spinal metastasis with right renal mass. The patient underwent right radical nephrectomy and the tumor was histopathologically confirmed as adult Wilms′ tumor. In case of adult Wilms′ tumor, distant metastasis may be the first presentation and this possibility should be considered when an adult patient presents with flank pain and a renal mass

Metastasis in central nervous system: Clinicopathological study with review of literature in a tertiary care center in South India

Background: Secondary central nervous system (CNS) tumors are common in Western countries, but in Indian literature, scant data are available. With the advent of newer imaging techniques, the confirmatory histopathological diagnosis has become comparatively easier. Hereby, we have analyzed our data from a single tertiary care center in south India. Materials and Methods: In this retrospective study from January 2000 to December 2010, histopathologically diagnosed secondary CNS tumors were reviewed along with clinical, imaging, and relevant immunohistochemical findings. Meningeal, lymphoproliferative, and myeloproliferative tumors and autopsy data were not included in the study group. Results: There were 40 secondary CNS tumors. Male to female ratio was 2.3:1. Age range was wide (28-75 years). Majority of cases were seen in the fourth and fifth decade. Imaging-wise, (computed tomography and magnetic resonance imaging) majority were single lesions ( n = 34, 85%). Most commonly, these single lesions were present in the cerebral hemisphere ( n = 20, 50%) followed by cerebellum ( n = 10, 25%). Adenocarcinoma accounted for maximum number of cases ( n = 25, 62.5%) with lungs being the most common primary. Conclusion: We have noted 25% metastatic adenocarcinomas in cerebellar location, which is higher when compared with available world literature. However, we also encountered a good number of cases (30%) due to unknown primary. Though histopathological examination with use of immunohistochemical markers can reliably distinguish primary from secondary CNS tumors in addition to available clinical and imaging data, particularly in developing countries, still a better work-up with an array of immunohistochemical markers and newer imaging modalities is desirable

Solid and cystic papillary neoplasm of pancreas: A clinic-pathological and immunohistochemical study: A tertiary care center experience

Background: Solid pseudopapillary tumor of the pancreas (SPT) is a rare tumor of low malignant potential, mostly described in young women. Materials and Methods: In this retrospective study from January 2000 - December 2010, there were 50 pancreatic tumors. In this period, four SPTs were encountered, which were analyzed with respect to clinical, imaging, histopathological, and immunohistochemical findings. Results: There was a female preponderance with mean age of 22.2 years. Two of the tumors were located in head of the pancreas and two in the body and tail region. On imaging, majority were large cystic tumors. Histopathologically, they exhibited extensive necrosis and presence of pseudo papillae in viable areas. Immunohistochemically, they were positive for alpha-1-anti-trypsin, alpha-1-anti-chymotrypsin, vimentin, CD10, and CD99. Progesterone receptor and p53 exhibited mild positivity in all of the four cases, whereas neuron specific enolase (NSE), synaptophysin, and chromogranin showed focal positivity in one case. Conclusion: Despite its non-specific clinical, imaging, and even immunohistochemical features, characteristic gross and microscopic findings provide reliable diagnosis of SPTs