A low noise, high thermal stability, 0.1 K test facility for the Planck HFI bolometers

We are developing a facility which will be used to characterize the bolometric detectors for Planck, an ESA mission to investigate the Cosmic Microwave Background. The bolometers operate at 0.1 K, employing neutron-transmutation doped (NTD) Ge thermistors with resistances of several megohms to achieve NEPs~1×10^(–17) W Hz^(–1/2). Characterization of the intrinsic noise of the bolometers at frequencies as low as 0.010 Hz dictates a test apparatus thermal stability of 40 nK Hz^(–1/2) to that frequency. This temperature stability is achieved via a multi-stage isolation and control geometry with high resolution thermometry implemented with NTD Ge thermistors, JFET source followers, and dedicated lock-in amplifiers. The test facility accommodates 24 channels of differential signal readout, for measurement of bolometer V(I) characteristics and intrinsic noise. The test facility also provides for modulated radiation in the submillimeter band incident on the bolometers, for measurement of the optical speed-of-response; this illumination can be reduced below detectable limits without interrupting cryogenic operation. A commercial Oxford Instruments dilution refrigerator provides the cryogenic environment for the test facility

The Herschel Lensing Survey (HLS): Overview

The Herschel Lensing Survey (HLS) will conduct deep PACS and SPIRE imaging of ∼40 massive clusters of galaxies. The strong gravitational lensing power of these clusters will enable us to penetrate through the confusion noise, which sets the ultimate limit on our ability to probe the Universe with Herschel. Here we present an overview of our survey and a summary of the major results from our science demonstration phase (SDP) observations of the Bullet cluster (z = 0.297). The SDP data are rich and allow us to study not only the background high-redshift galaxies (e.g., strongly lensed and distorted galaxies at z = 2.8 and 3.2) but also the properties of cluster-member galaxies. Our preliminary analysis shows a great diversity of far-infrared/submillimeter spectral energy distributions (SEDs), indicating that we have much to learn with Herschel about the properties of galaxy SEDs. We have also detected the Sunyaev-Zel’dovich (SZ) effect increment with the SPIRE data. The success of this SDP program demonstrates the great potential of the Herschel Lensing Survey to produce exciting results in a variety of science areas

Observation of H_2O in a strongly lensed Herschel-ATLAS source at z = 2.3

The Herschel survey, H-ATLAS, with its large areal coverage, has recently discovered a number of bright, strongly lensed high-z submillimeter galaxies. The strong magnification makes it possible to study molecular species other than CO, which are otherwise difficult to observe in high-z galaxies. Among the lensed galaxies already identified by H-ATLAS, the source J090302.9-014127B (SDP.17b) at z = 2.305 is remarkable because of its excitation conditions and a tentative detection of the H_2O 2_(02)-1_(11) emission line (Lupu et al. 2010, ApJ, submitted). We report observations of this line in SDP.17b using the IRAM interferometer equipped with its new 277–371 GHz receivers. The H_2O line is detected at a redshift of z = 2.3049 ± 0.0006, with a flux of 7.8 ± 0.5 Jy km s^(-1) and a FWHM of 250 ± 60   km   s^(-1). The new flux is 2.4 times weaker than the previous tentative detection, although both remain marginally consistent within 1.6σ. The intrinsic line luminosity and ratio of H_2O(2_(02) − 1_(11))/CO(8 − 7) are comparable with those of the nearby starburst/enshrouded-AGN Mrk 231, and the ratio I(H_2O)/L_(FIR) is even higher, suggesting that SDP.17b could also host a luminous AGN. The detection of a strong H_2O 2_(02) − 1_(11) line in SDP.17b implies an efficient excitation mechanism of the water levels that must occur in very dense and warm interstellar gas probably similar to Mrk 231

Initial test results on bolometers for the Planck high frequency instrument

We summarize the fabrication, flight qualification, and dark performance of bolometers completed at the Jet Propulsion Laboratory for the High Frequency Instrument (HFI) of the joint ESA/NASA Herschel/Planck mission to be launched in 2009. The HFI is a multicolor focal plane which consists of 52 bolometers operated at 100 mK. Each bolometer is mounted to a feedhorn-filter assembly which defines one of six frequency bands centered between 100-857 GHz. Four detectors in each of five bands from 143-857 GHz are coupled to both linear polarizations and thus measure the total intensity. In addition, eight detectors in each of four bands (100, 143, 217, and 353 GHz) couple only to a single linear polarization and thus provide measurements of the Stokes parameters, Q and U, as well as the total intensity. The measured noise equivalent power (NEP) of all detectors is at or below the background limit for the telescope and time constants are a few ms, short enough to resolve point sources as the 5 to 9 arc min beams move across the sky at 1 rpm

An \emph{ab initio} method for locating characteristic potential energy minima of liquids

It is possible in principle to probe the many--atom potential surface using density functional theory (DFT). This will allow us to apply DFT to the Hamiltonian formulation of atomic motion in monatomic liquids [\textit{Phys. Rev. E} {\bf 56}, 4179 (1997)]. For a monatomic system, analysis of the potential surface is facilitated by the random and symmetric classification of potential energy valleys. Since the random valleys are numerically dominant and uniform in their macroscopic potential properties, only a few quenches are necessary to establish these properties. Here we describe an efficient technique for doing this. Quenches are done from easily generated "stochastic" configurations, in which the nuclei are distributed uniformly within a constraint limiting the closeness of approach. For metallic Na with atomic pair potential interactions, it is shown that quenches from stochastic configurations and quenches from equilibrium liquid Molecular Dynamics (MD) configurations produce statistically identical distributions of the structural potential energy. Again for metallic Na, it is shown that DFT quenches from stochastic configurations provide the parameters which calibrate the Hamiltonian. A statistical mechanical analysis shows how the underlying potential properties can be extracted from the distributions found in quenches from stochastic configurations

Expression of cadherin and NCAM in human small cell lung cancer cell lines and xenografts.

Tumour cell adhesion, detachment and aggregation seem to play an important part in tumour invasion and metastasis, and numerous cell adhesion molecules are expressed by tumour cells. Several families of cell-cell adhesion molecules have been described, of which two groups are particularly well characterised, the cadherin family and the Ig superfamily member, neural cell adhesion molecule (NCAM). We investigated expression of these two adhesion molecule families in small cell lung cancer (SCLC) cell lines and xenografts by immunoblotting. Nineteen tumours established from 15 patients with SCLC were examined. All tumours but one expressed both cadherin and NCAM. The tumours expressed one, two or rarely three cadherin bands, and different combinations of two major isoforms of NCAM with M(r)'s of approximately 190,000 and 135,000. Polysialylation of NCAM, a feature characteristic of NCAM during embryonic development, which may play a role in connection with tumour invasion and metastasis, was found in 14/18 NCAM expressing SCLC tumours. Individual tumours grown as cell lines and as nude mouse xenografts showed no qualitative differences in cadherin or NCAM expression

MolLoc: a web tool for the local structural alignment of molecular surfaces

MolLoc stands for Molecular Local surface comparison, and is a web server for the structural comparison of molecular surfaces. Given two structures in PDB format, the user can compare their binding sites, cavities or any arbitrary residue selection. Moreover, the web server allows the comparison of a query structure with a list of structures. Each comparison produces a structural alignment that maximizes the extension of the superimposition of the surfaces, and returns the pairs of atoms with similar physicochemical properties that are close in space after the superimposition. Based on this subset of atoms sharing similar physicochemical properties a new rototranslation is derived that best superimposes them. MolLoc approach is both local and surface-oriented, and therefore it can be particularly useful when testing if molecules with different sequences and folds share any local surface similarity. The MolLoc web server is available at http://bcb.dei.unipd.it/MolLoc

Mesh Independency Analyses and Grid Density Estimation for Ventricular Assist Devices in Multiple Reference Frames Simulations

The evolution of mechanical circulatory supports has been essential to improve life quality for heart disease patients. The ventricular assist devices (VAD) developments, for example, incorporated computational engineering in its process to reach more robust devices. A concern in VAD developments still being the dynamics of the flow inside blood pumps, and so computational fluid dynamics (CFD) has being studied and applied to these developments processes. In CFD, many aspects become relevant and essential, especially in turbulent flows in which numerical and physical instabilities may cause divergence or false results. In order to reduce the numerical error and guarantee an appropriate fluid domain representation, mesh independency is essential to reach reasonable results. In this context this work is presented, as support for grid density estimation from precision analysis, since accuracy to real data is not numerically relevant in mesh independency determination. Ansys Fluent was used for performing 36 simulations with different grid densities for a VAD prototype, applying multiple reference frames (MRF) methodology. Grid densities incorporate the number of elements in a reference frame and the geometric scale of a VAD, what creates comparison parameters for use in other fluid flow simulations using MRF applied to VADs. In each reference frame, although, this density might be different for optimization of computational costs and to reach trustful results. Another concern felt in the fluid-fluid interface between the two reference frames, keeping concordance and soft transitions between the frames meshes, aiming to reduce locally numerical error propagations. The impeller Reynolds number is around 2800 and the inlet Reynolds number is 317. Despite the low Reynolds number, turbulence may occur and standard k-e model is applied for turbulent flow analyses. The blood is considered as Newtonian and incompressible fluid due to velocities and fluid deformations expected, thus mean values are applied for density and effective viscosity: 1059kg/m³ and 0,004Pa.s. Simulations are compared in global analysis, verifying the pressure difference between inlet and outlet, and in specific analysis, observing the fluid flow behavior, aiming for changeless. Both analyses are based on numerical precision, what means the simulations are compared mutually, changing the grid density scenarios. Results suggest independency of mesh size from 13 million of elements, with variance coefficient around 0,7%, and grid density parameters are purposed as references for mesh disposal in VAD simulations in same conditions. The use of 318,43 elements per mm³ and 210,14 elements per mm³ are sufficiently to assure mesh size independency for non-inertial (near the rotor) and inertial frames, respectively. The purpose of this work is to reach a grid density parameter for applying in future similar simulations and analyze mesh influence on the specific results of the blood flow inside the prototype VAD. The goals are to reach and as conclusion a minimum grid density is purposed for VAD simulations applying MRF in the similar or lower impeller Reynolds numbers, and probably for higher impeller Reynolds numbers as well

Redshift Determination and CO Line Excitation Modeling for the Multiply Lensed Galaxy HLSW-01

We report on the redshift measurement and CO line excitation of HERMES J105751.1+573027 (HLSW-01), a strongly lensed submillimeter galaxy discovered in Herschel/SPIRE observations as part of the Herschel Multi-tiered Extragalactic Survey (HerMES). HLSW-01 is an ultra-luminous galaxy with an intrinsic far-infrared luminosity of L _(FIR) = 1.4 × 10^(13) L _⊙, and is lensed by a massive group of galaxies into at least four images with a total magnification of μ = 10.9 ± 0.7. With the 100 GHz instantaneous bandwidth of the Z-Spec instrument on the Caltech Submillimeter Observatory, we robustly identify a redshift of z = 2.958 ± 0.007 for this source, using the simultaneous detection of four CO emission lines (J = 7 → 6, J = 8 → 7, J = 9 → 8, and J = 10 → 9). Combining the measured line fluxes for these high-J transitions with the J = 1 → 0, J = 3 → 2, and J = 5 → 4 line fluxes measured with the Green Bank Telescope, the Combined Array for Research in Millimeter Astronomy, and the Plateau de Bure Interferometer, respectively, we model the physical properties of the molecular gas in this galaxy. We find that the full CO spectral line energy distribution is described well by warm, moderate-density gas with T _(kin) = 86-235 K and n_H_2 = (1.1-3.5)x10^3 cm^(–3). However, it is possible that the highest-J transitions are tracing a small fraction of very dense gas in molecular cloud cores, and two-component models that include a warm/dense molecular gas phase with T _(kin) ~ 200 K, n_H_2 ~ 10^5 cm^(–3) are also consistent with these data. Higher signal-to-noise measurements of the J _(up) ≥ 7 transitions with high spectral resolution, combined with high spatial resolution CO maps, are needed to improve our understanding of the gas excitation, morphology, and dynamics of this interesting high-redshift galaxy