Preparation of Ni-63 Radioactive Source by Hanging Plating Method

In order to optimize the problems of low efficiency and complex equipment in the preparation of nickel-63 radioactive sources using traditional electrodeposition processes. A high-efficiency process for preparing nickel-63 radiation sources has been developed using nickel chloride (Ni-63) as raw material, nickel as substrate, and hanging plating process. The effects of pH value of electroplating solution, electroplating temperature, electroplating time, and electroplating current density on the quality of nickel-63 radioactive source products were studied. Under the conditions of nickel chloride (Ni-63) concentration of 7 g/L, pH value 1-3, electroplating temperature at room temperature, electroplating time of 180 seconds, and current density of 6.5 mA/cm2, qualified nickel-63 radiation source products were efficiently prepared. The results show that compared with traditional electrodeposition processes, this process breaks the limitations of electroplating tank design and overcomes the complex design of electroplating equipment in traditional electrodeposition processes. It can flexibly design the shape of the active zone of the radioactive source, solve the problem of frequent disassembly of electroplating equipment in the production process, and improves the production efficiency

First-principles study on the p-orbital multiferroicity of single-layer XN (X = Ge, Sn, Pb)

Two-dimensional (2D) multiferroic materials have triggered a burst of interest owing to their wide applications in nanoelectronics. Specifically, p-orbital multiferroicity is strongly desired but has been very few reported. Here, based on first-principles calculations, we unveil a new type of 2D multiferroic material: the single-layer (SL) XN (X = Ge, Sn, Pb). Our findings show these materials are ferromagnetic semiconductors with strong magnetoelectric coupling and wide bandgaps. The multiferroicity is related to the unpaired p-orbital electrons of N atoms and the buckled crystal structure. All the single layers show easy-plane magnetocrystalline anisotropy, and the magnetic anisotropy energy increases significantly with the atomic number increasing. Our Monte Carlo simulations suggest the Curie temperature TC is 205.44 K, 200.45 K, and 287.88 K for SL GeN, SnN, and PbN, respectively. By applying tensile strain, the TC can be further increased to 225.39 K, 245.35 K, 369.99 K, respectively. Additionally, biaxial strain can induce semiconductor-to-half-metal and ferroelectricity-to-paraelectricity transition in the single layers. We aspire that our work contributes to the exploration of room-temperature p-orbital multiferroicity

Complete mitochondrial genome sequence of Labriocimbex sinicus, a new genus and new species of Cimbicidae (Hymenoptera) from China

Labriocimbex sinicus Yan & Wei gen. et sp. nov. of Cimbicidae is described. The new genus is similar to Praia Andre and Trichiosoma Leach. A key to extant Holarctic genera of Cimbicinae is provided. To identify the phylogenetic placement of Cimbicidae, the mitochondrial genome of L. sinicus was annotated and characterized using high-throughput sequencing data. The complete mitochondrial genome of L. sinicus was obtained with a length of 15,405 bp (GenBank: MH136623; SRA: SRR8270383) and a typical set of 37 genes (22 tRNAs, 13 PCGs, and two rRNAs). The results demonstrated that all PCGs were initiated by ATN codon, and ended with TAA or T stop codons. The study reveals that all tRNA genes have a typical clover-leaf secondary structure, except for trnS1. Remarkably, the secondary structures of the rrnS and rrnL of L. sinicus were much different from those of Corynis lateralis. Phylogenetic analyses verified the monophyly and positions of the three Cimbicidae species within the superfamily Tenthredinoidea and demonstrated a relationship as (Tenthredinidae + Cimbicidae) + (Argidae + Pergidae) with strong nodal supports. Furthermore, we found that the generic relationships of Cimbicidae revealed by the phylogenetic analyses based on COI genes agree quite closely with the systematic arrangement of the genera based on the morphological characters. Phylogenetic tree based on two methods shows that L. sinicus is the sister group of Praia with high support values. We suggest that Labriocimbex belongs to the tribe Trichiosomini of Cimbicinae based on adult morphology and molecular data. Besides, we suggest to promote the subgenus Asitrichiosoma to be a valid genus

A classic prescription alleviates inflammation in CUMS model mice via modulating MYDGF/MAP4K4/NF-κB signaling pathway, verified through UPLC-HRMS and proteomics analysis

Background: Xiaoyaosan (XYS), a renowned classical traditional Chinese medicinal formula utilized in addressing major depressive disorder (MDD), has garnered significant acclaim for its remarkable efficacy in clinical application. The onset of major depressive disorder (MDD) often correlates with chronic unpredictable mild stress (CUMS), a pivotal instigating factor in its development.Aim of the study: This study aims to clarify the potential anti-inflammatory mechanisms of XYS in treating CUMS model mice. Materials and methods: Utilizing cutting-edge ultra high-performance liquid chromatography - high-resolution mass spectrometry (UPLC-HRMS), the active constituents of XYS were discerned, while employing proteomics analysis to delve into the potential mechanisms of its efficacy. Molecular docking studies, alongside subsequent in vivo experiments utilizing CUMS model mice, were conducted to corroborate the findings derived from the proteomics analysis. Results: In vivo experiments demonstrated that XYS not only markedly ameliorated behavioral markers but also attenuated serum inflammatory markers and suppressed IL-6 and TNF-α expression within the brains of CUMS model mice. Proteomics analysis suggested that the pivotal anti-inflammatory mechanism of XYS against CUMS-induced damage might involve modulation of the MAPK signaling pathway. Utilizing UPLC-HRMS, the active constituents of XYS were successfully identified, while molecular docking investigations explored interactions between XYS and MYDGF, PKC, MAP4K4, P-p65, p65, P-IKBα, and IKBα. The findings revealed XYS's regulatory influence on the MYDGF/MAP4K4/NF-κB signaling cascade. Conclusions: This study is the first to our knowledge to demonstrate that XYS can alleviate inflammation in CUMS model mice by modulating the MYDGF/MAP4K4/NF-κB signaling pathway