Development and Testing of Woven FRP Flexure Hinges for Pressure-Actuated Cellular Structures with Regard to Morphing Wing Applications

Shape-variable structures can change their geometry in a targeted way and thus adapt their outer shape to different operating conditions. The potential applications in aviation are manifold and far-reaching. The substitution of conventional flaps in high-lift systems or even the deformation of entire wing profiles is conceivable. All morphing approaches have to deal with the same challenge: A conflict between minimizing actuating forces on the one hand, and maximizing structural deflections and resistance to external forces on the other. A promising concept of shape variability to face this challenging conflict is found in biology. Pressure-actuated cellular structures (PACS) are based on the movement of nastic plants. Firstly, a brief review of the holistic design approach of PACS is presented. The aim of the following study is to investigate manufacturing possibilities for woven flexure hinges in closed cellular structures. Weaving trials are first performed on the material level and finally on a five-cell PACS cantilever. The overall feasibility of woven fiber reinforced plastics (FRP)-PACS is proven. However, the results show that the materials selection in the weaving process substantially influences the mechanical behavior of flexure hinges. Thus, the optimization of manufacturing parameters is a key factor for the realization of woven FRP-PACS

PACS - Realization of an adaptive concept using pressure actuated cellular structures

A biologically inspired concept is investigated which can be utilized to develop energy efficient, lightweight and applicational flexible adaptive structures. Building a real life morphing unit is an ambitious task as the numerous works in the particular field show. Summarizing fundamental demands and barriers regarding shape changing structures, the basic challenges of designing morphing structures are listed. The concept of Pressure Actuated Cellular Structures (PACS) is arranged within the recent morphing activities and it is shown that it complies with the underlying demands. Systematically divided into energy-related and structural subcomponents the working principle is illuminated and relationships between basic design parameters are expressed. The analytical background describing the physical mechanisms of PACS is presented in concentrated manner. This work focuses on the procedure of dimensioning, realizing and experimental testing of a single cell and a single row cantilever made of PACS. The experimental outcomes as well as the results from the FEM computations are used for evaluating the analytical methods. The functionality of the basic principle is thus validated and open issues are determined pointing the way ahead

Phase Separation of FUS Is Suppressed by Its Nuclear Import Receptor and Arginine Methylation

Purpose of Review Advances in technology have expanded telemedicine opportunities covering medical practice, research, and education. This is of particular importance in movement disorders (MDs), where the combination of disease progression, mobility limitations, and the sparse distribution of MD specialists increase the difficulty to access. In this review, we discuss the prospects, challenges, and strategies for telemedicine in MDs.Recent Findings Telemedicine for MDs has been mainly evaluated in Parkinson's disease (PD) and compared to in-office care is cost-effective with similar clinical care, despite the barriers to engagement. However, particular groups including pediatric patients, rare MDs, and the use of telemedicine in underserved areas need further research.Summary Interdisciplinary telemedicine and tele-education for MDs are feasible, provide similar care, and reduce travel costs and travel time compared to in-person visits. These benefits have been mainly demonstrated for PD but serve as a model for further validation in other movement disorders