The Prevalence and Impact of Obesity on the Outcomes of Patients Undergoing Transcatheter Mitral Valve Repair using MitraClip - A National Inpatient Sample Analysis 2016 to 2020.

Background: Low Body Mass Index (BMI) is associated with poor outcomes in patients who undergo various cardiac interventions. Studies on patients with elevated BMI have produced mixed results. Our study aims to evaluate the impact of obesity on the in-hospital outcomes of patients undergoing transcatheter mitral valve repair using MitraClip in the United States. Methods: The National Inpatient Sample (NIS) database (2016-2020) was analyzed to identify patients who underwent transcatheter mitral valve repair using MitraClip. Patients less than 18 years, with protein-energy malnutrition and rapid weight loss, were excluded. Our final study population was classified into Obese (BMI ≥ 30 Kg/m2) and Non-obese (Normal/Overweight) (BMI 0f 18.5 -29.9 Kg/m2) cohorts based on their Body Mass Index (BMI). The primary outcomes were the prevalence of obesity and in-hospital mortality. Secondary outcomes were the rate of periprocedural complications, including cardiogenic shock, cardiac arrest, myocardial infarction, and acute kidney injury. Result: 40,950 patients underwent transcatheter mitral valve repair (MitraClip) during our study period. 7.8% were identified as obese. Obese patients were more likely to be female (50.6% vs. 43.9%, p Conclusions: Our study suggests obesity does not influence short-term in-hospital outcomes in patients undergoing transcatheter mitral valve repair using MitraClip

Renal and mesenteric artery intervention

Atherosclerotic renal artery stenosis is the most common cause of secondary hypertension and may cause progressive renal disease and cardiac destabilization syndromes. Guideline-directed medical therapy is advised in all patients. Patients with refractory symptoms and hemodynamically significant stenoses are more likely to benefit from renal artery stent placement. Chronic mesenteric ischemia (CMI) is an infrequent and difficult to diagnose illness. Due to robust collateralization, clinical symptoms from mesenteric artery stenosis or occlusion is uncommon. Atherosclerosis is the most common etiology of CMI. Current evidence suggests that, compared with open surgical repair, endovascular therapy is the most cost-effective choice for CMI

Non-arrhythmic causes of sudden death: a comprehensive review

Sudden cardiac death (SCD)is a major public health issue in the United States and worldwide. It is estimated to affect between 1 and 1.5 million patients worldwide annually, with the global burden expected to rise due to the concomitant rise in coronary artery disease in the developing world. Although arrhythmic causes of SCD such as ventricular tachycardia and ventricular fibrillation are common and well-studied, non-arrhythmic causes are also important, with diverse etiologies from ischemia-related structural heart disease to non-ischemic heart diseases, non-atherosclerotic coronary pathologies, and inflammatory states. Recent research has also found that risk factors and/or demographics predispose certain individuals to a higher risk of non-arrhythmia-related SCD. This review discusses the epidemiology, mechanisms, etiologies, and management of non-arrhythmic SCD

Renal revascularization in resistant hypertension

Renal artery stenosis (RAS) is a common cause of secondary hypertension (HTN) and may lead to resistant (refractory) HTN despite guideline directed medical therapy. Although randomized controlled trials comparing medical therapy to medical therapy and renal artery stenting have shown no benefit with renal artery stenting, according to comparative effectiveness reviews by the Agency for Healthcare Research and Quality, the trials did not enroll patients with the most severe RAS who would be more likely to benefit from renal stenting. Because of limitations of conventional angiography, it is important to assess the hemodynamic severity of moderate (50%-70%) RAS lesions with a hemodynamic measurement. We review techniques to optimize patient selection, to minimize procedural complications, and to facilitate durable patency of renal stenting. We also review the current ACC/AHA Guidelines and SCAI Appropriate Use Criteria as they relate to renal stenting. (C) 2019 Elsevier Inc. All rights reserved

Renaldenervation: alternative treatment options for hypertension?

Hypertension affects millions of Americans and has adverse long-term consequences increasing morbidity and mortality. Resistant hypertension (RH) continues to be difficult to treat with medications alone which may be associated with significant side effects. Alternate therapies have been evaluated for treating RH and renal denervation has been investigated extensively. We review the data from renal denervation trials and other novel technologies which are not FDA approved to date

The top 100 cited articles on spontaneous coronary artery dissection: a bibliometric analysis

Aim: This study identifies the most cited papers on spontaneous coronary artery dissection and evaluates their focus and the characteristics of the current literature. Methods: The Web of Science database was queried for publications between 1971 and 2021. The articles were ranked from the most to the least citations, and each was reviewed by two authors. Results: The total citations ranged from 44 to 457, with a median (interquartile range) citation of 78.5 (60-140). Females were 28% of the first authors, about half the papers (52/100) were published in the last decade, most were observational studies (78/100) and the rest were nonoriginal studies. The impact factor of the journal weakly correlated with the number of citations (r [98] = 0.24; p = 0.018). Conclusion: Efforts are needed to encourage female authorship and increase the quality of articles in this subject area