3 research outputs found
Micro- and Nanoscale Control of the Cardiac Stem Cell Niche for Tissue Fabrication
- Publication venue
- 'Mary Ann Liebert Inc'
- Publication date
- 01/01/2009
- Field of study
Advances in stem cell (SC) biology have greatly enhanced our understanding of SC self-renewal and differentiation. Both embryonic and adult SCs can be differentiated into a great variety of tissue cell types, including cardiac myocytes. In vivo studies and clinical trials, however, have demonstrated major limitations in reconstituting the myocardium in failing hearts. These limitations include precise control of SC proliferation, survival and phenotype both prior and subsequent to transplantation and avoidance of serious adverse effects such as tumorigenesis and arrhythmias. Micro- and nanoscale techniques to recreate SC niches, the natural environment for the maintenance and regulation of SCs, have enabled the elucidation of novel SC behaviors and offer great promise in the fabrication of cardiac tissue constructs. The ability to precisely manipulate the interface between biopolymeric scaffolds and SCs at in vivo scale resolutions is unique to micro- and nanoscale approaches and may help overcome limitations of conventional biological scaffolds and methods for cell delivery. We now know that micro- and nanoscale manipulation of scaffold composition, mechanical properties, and three-dimensional architecture have profound influences on SC fate and will likely prove important in developing the next generation of “transplantable SC niches” for regeneration of heart and other tissues. In this review, we examine two key aspects of micro- and nanofabricated SC-based cardiac tissue constructs: the role of scaffold composition and the role of scaffold architecture and detail how recent work in these areas brings us closer to clinical solutions for cardiovascular regeneration
Electrospun PLGA Fibers Incorporated with Functionalized Biomolecules for Cardiac Tissue Engineering
- Publication venue
- 'Mary Ann Liebert Inc'
- Publication date
- Field of study
Exploring the cost-effectiveness of high versus low perioperative fraction of inspired oxygen in the prevention of surgical site infections among abdominal surgery patients in three low- and middle-income countries
- Author
- A.A. Essam
- A.B. Jayathilake
- Abbas Chabok
- Abd Elkhalek Sallam
- Abdalla Gamal Saad
- Abdelaziz Abdelaal
- Abdelaziz Elhendawy
- Abdelkader Belkouchi
- Abdelmalek Hrora
- Abdelrahman Adelshone
- Abdelrahman Assal
- Abdelrahman Geuoshy
- Abdelrahman Soliman
- Abdelrhman K.Z. Darwish
- Abdul Rehman Alvi
- Abdulaziz Altwijri
- Abdullah Altamimi
- Abdullah Hashim
- Abdulmalik Altaf
- Abdulrahman Abdel-Aty
- Abdulrasheed Nasir
- Abdulrazzaq Lawal
- Abdulshafi Khaled Abdrabou
- Abdurrahaman Sheshe
- Abdussemiu Abdurrazzaaq
- Abeer Esam
- Abhishek Sharma
- Abiboye Yifieyeh
- Abobaker Younis
- Abrar Nawawi
- Adam Boggon
- Adam Gyedu
- Ade Waterman
- Adedapo Osinowo
- Adedeji Fatuga
- Adel Albiety
- Adel B. Hassanein
- Adel Denewar
- Ademola Adebanjo
- Ademola Adeyeye
- Ademola Adeyeye
- Ademola Popoola
- Adesina Adedeji
- Adesoji Ademuyiwa
- Adesoji O. Ademuyiwa
- Adesoji O. Ademuyiwa
- Adesoji O. Ademuyiwa
- Adesoji O. Ademuyiwa
- Adewale Adeniyi
- Adewale O. Adisa
- Adham Tarek
- Adomas Ladukas
- Adrian Palma
- Adrienne Ho
- Afifatun Hasanah
- Afizah Salleh
- Afnan Abdelfatah
- Afnan Altamimi
- Afnan Altamini
- Agazi Fitsum
- Agboola Taiwo
- Ahed Ghaben
- Ahmad Abdel Razaq Al Rafati
- Ahmad Aboelkassem Ibrahem
- Ahmad Ashour
- Ahmad Ashour
- Ahmad Bakr
- Ahmad Bani-Sadar
- Ahmad Bin Adnan
- Ahmad Gudal
- Ahmad Gudal
- Ahmad Hasan
- Ahmad Khaled Sabe
- Ahmad Khoja
- Ahmad Qaissieh
- Ahmad Sabe
- Ahmad Saber Sleem
- Ahmad Sakr
- Ahmad Shalabi
- Ahmad Uzair Qureshi
- Ahmad Uzair Qureshi
- Ahmed Aamer
- Ahmed Abd Elmoen Elhusseiny
- Ahmed Abd Elsameea
- Ahmed Adamu
- Ahmed Al-Bahrani
- Ahmed Al-Khatib
- Ahmed Alghamdi
- Ahmed Ali
- Ahmed Altibi
- Ahmed Alzahrani
- Ahmed Ata
- Ahmed Dahy
- Ahmed El Kashash
- Ahmed El-Sehily
- Ahmed Essam
- Ahmed Farag
- Ahmed Gad
- Ahmed Ghanem
- Ahmed Hossam Eldin Fouad Rida
- Ahmed Ismail
- Ahmed M. Rashed
- Ahmed Magdy
- Ahmed Mahmoud Abdelraouf
- Ahmed mohamed Ibrahim
- Ahmed Moustafa
- Ahmed Rabeih Mohammed
- Ahmed Rabie Mohamed
- Ahmed Raza
- Ahmed Saidbadr
- Ahmed Shahine
- Ahmed Sheta
- Ahmed Soliman
- Ahmed Tarek Abdelbaset Hassan
- Ahmed W. Shamsedine
- Ahmed Zaki
- Ahmed Zaki Eldeeb
- Ahmed Zohair
- Ahmedali M. Kandil
- Ahmedglal Elnagar
- Ahmet Murat Pektaş
- Aia Mehdi
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- Alberto Miyar de León
- Alberto Realis Luc
- Alejandro Matheu
- Alemayehu Ginbo Bedada
- Alessandro Favero
- Alex Makupe
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- Alexia Farrugia
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- Yakubu Momohsani Adinoyi
- Yasmin Elfouly
- Yasmin Soliman
- Ye Ru Chin
- Yee Wen Tan
- Yehia Zakaria
- Yi Koon Tan
- Yi Ting Mok
- Yih Jeng Cheong
- Yiing Yee Gan
- Yishan Der
- Yomna Allam
- Yomna Hosny Asar
- Yong Yong Tew
- Yong Yong Tew
- Yoshan Moodley
- Yousef Abuowda
- Ysabel Esthefany Alejos Bermúdez
- Yucel Cengiz
- Yucel Cengiz
- Yuk Hong Eric Cheung
- Yuksel Altinel
- Yuksel Altinel
- Yun Lin Ang
- Yung Kok Ng
- Yuri Macchitella
- Zahra Jaffry
- Zain Ali Khan
- Zainab Iftikhar
- Zakaria Rob
- Zhan Herr Ng
- Zi Hao Sam
- Zigmantas Urniežius
- Zilvinas Dambrauskas
- Zineb Bentounsi
- Zygimantas Tverskis
- Ömer Faruk Toto
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/09/2023
- Field of study
Background: This study assessed the potential cost-effectiveness of high (80–100%) vs low (21–35%) fraction of inspired oxygen (FiO2) at preventing surgical site infections (SSIs) after abdominal surgery in Nigeria, India, and South Africa. Methods: Decision-analytic models were constructed using best available evidence sourced from unbundled data of an ongoing pilot trial assessing the effectiveness of high FiO2, published literature, and a cost survey in Nigeria, India, and South Africa. Effectiveness was measured as percentage of SSIs at 30 days after surgery, a healthcare perspective was adopted, and costs were reported in US dollars ().Results:HighFiO2maybecost−effective(cheaperandeffective).InNigeria,theaveragecostforhighFiO2was216 compared with 222forlowFiO2leadingtoa −6 (95% confidence interval [CI]: −13to −1) difference in costs. In India, the average cost for high FiO2 was 184comparedwith195 for low FiO2 leading to a −11(9515 to −6)differenceincosts.InSouthAfrica,theaveragecostforhighFiO2was1164 compared with 1257forlowFiO2leadingtoa −93 (95% CI: −132to −65) difference in costs. The high FiO2 arm had few SSIs, 7.33% compared with 8.38% for low FiO2, leading to a −1.05 (95% CI: −1.14 to −0.90) percentage point reduction in SSIs. Conclusion: High FiO2 could be cost-effective at preventing SSIs in the three countries but further data from large clinical trials are required to confirm this