1,848 research outputs found
The Supernova Gamma-Ray Burst Connection
The chief distinction between ordinary supernovae and long-soft gamma-ray
bursts (GRBs) is the degree of differential rotation in the inner several solar
masses when a massive star dies, and GRBs are rare mainly because of the
difficulty achieving the necessary high rotation rate. Models that do provide
the necessary angular momentum are discussed, with emphasis on a new single
star model whose rapid rotation leads to complete mixing on the main sequence
and avoids red giant formation. This channel of progenitor evolution also gives
a broader range of masses than previous models, and allows the copious
production of bursts outside of binaries and at high redshifts. However, even
the production of a bare helium core rotating nearly at break up is not, by
itself, a sufficient condition to make a gamma-ray burst. Wolf-Rayet mass loss
must be low, and will be low in regions of low metallicity. This suggests that
bursts at high redshift (low metallicity) will, on the average, be more
energetic, have more time structure, and last longer than bursts nearby. Every
burst consists of three components: a polar jet (~0.1 radian), high energy,
subrelativistic mass ejection (~1 radian), and low velocity equatorial mass
that can fall back after the initial explosion. The relative proportions of
these three components can give a diverse assortment of supernovae and high
energy transients whose properties may vary with redshift.Comment: 10 pages, to appear in AIP Conf. Proc. "Gamma Ray Bursts in the Swift
Era", Eds. S. S. Holt, N. Gehrels, J. Nouse
High Energy Gamma-Ray Emission From Blazars: EGRET Observations
We will present a summary of the observations of blazars by the Energetic
Gamma Ray Experiment Telescope (EGRET) on the Compton Gamma Ray Observatory
(CGRO). EGRET has detected high energy gamma-ray emission at energies greater
than 100 MeV from more that 50 blazars. These sources show inferred isotropic
luminosities as large as ergs s. One of the most
remarkable characteristics of the EGRET observations is that the gamma-ray
luminosity often dominates the bolometric power of the blazar. A few of the
blazars are seen to exhibit variability on very short time-scales of one day or
less. The combination of high luminosities and time variations seen in the
gamma-ray data indicate that gamma-rays are an important component of the
relativistic jet thought to characterize blazars. Currently most models for
blazars involve a beaming scenario. In leptonic models, where electrons are the
primary accelerated particles, gamma-ray emission is believed to be due to
inverse Compton scattering of low energy photons, although opinions differ as
to the source of the soft photons. Hardronic models involve secondary
production or photomeson production followed by pair cascades, and predict
associated neutrino production.Comment: 16 pages, 7 figures, style files included. Invited review paper in
"Observational Evidence for Black Holes in the Universe," 1999, ed. S. K.
Chakrabarti (Dordrecht: Kluwer), 215-23
What do -ray bursts look like?
There have been great and rapid progresses in the field of -ray
bursts (denoted as GRBs) since BeppoSAX and other telescopes discovered their
afterglows in 1997. Here, we will first give a brief review on the
observational facts of GRBs and direct understanding from these facts, which
lead to the standard fireball model. The dynamical evolution of the fireball is
discussed, especially a generic model is proposed to describe the whole
dynamical evolution of GRB remnant from highly radiative to adiabatic, and from
ultra-relativistic to non-relativistic phase. Then, Various deviations from the
standard model are discussed to give new information about GRBs and their
environment. In order to relax the energy crisis, the beaming effects and their
possible observational evidences are also discussed in GRB's radiations.Comment: 10 pages, Latex. Invited talk at the Pacific Rim Conference on
Stellar Astrophysics, Hong Kong, China, Aug. 199
Sliding charge density wave in manganites
The so-called stripe phase of the manganites is an important example of the
complex behaviour of metal oxides, and has long been interpreted as the
localisation of charge at atomic sites. Here, we demonstrate via resistance
measurements on La_{0.50}Ca_{0.50}MnO_3 that this state is in fact a
prototypical charge density wave (CDW) which undergoes collective transport.
Dramatic resistance hysteresis effects and broadband noise properties are
observed, both of which are typical of sliding CDW systems. Moreover, the high
levels of disorder typical of manganites result in behaviour similar to that of
well-known disordered CDW materials. Our discovery that the manganite
superstructure is a CDW shows that unusual transport and structural properties
do not require exotic physics, but can emerge when a well-understood phase (the
CDW) coexists with disorder.Comment: 13 pages; 4 figure
Success of microvascular surgery; repair mesenteric injury and prevent short bowel syndrome: a case report
This is an Open Access article distributed under the terms of the Creative Commons Attribution Licens
The influence on survival of delay in the presentation and treatment of symptomatic breast cancer
The aim of this study was to examine the possible influence on survival of delays prior to presentation and/or treatment among women with breast cancer. Duration of symptoms prior to hospital referral was recorded for 2964 women who presented with any stage of breast cancer to Guy's Hospital between 1975 and 1990. Median follow-up is 12.5 years. The impact of delay (defined as having symptoms for 12 or more weeks) on survival was measured from the date of diagnosis and from the date when the patient first noticed symptoms to control for lead-time bias. Thirty-two per cent (942/2964) of patients had symptoms for 12 or more weeks before their first hospital visit and 32% (302/942) of patients with delays of 12 or more weeks had locally advanced or metastatic disease, compared with only 10% (210/2022) of those with delays of less than 12 weeks (P< 0.0001). Survival measured both from the date of diagnosis (P< 0.001) and from the onset of the patient's symptoms (P= 0.003) was worse among women with longer delays. Ten years after the onset of symptoms, survival was 52% for women with delays less than 12 weeks and 47% for those with longer delays. At 20 years the survival rates were 34% and 24% respectively. Furthermore, patients with delays of 12–26 weeks had significantly worse survival rates than those with delays of less than 12 weeks. Multivariate analyses indicated that the adverse impact of delay in presentation on survival was attributable to an association between longer delays and more advanced stage. However, within individual stages, longer delay had no adverse impact on survival. Analyses based on ‘total delay’ (i.e. the interval between a patient first noticing symptoms and starting treatment) yielded very similar results in terms of survival to those based on delay to first hospital visit (delay in presentation). © 1999 Cancer Research Campaig
Assessment of low-dose cisplatin as a model of nausea and emesis in beagle dogs, potential for repeated administration
Cisplatin is a highly emetogenic cancer chemotherapy agent, which is often used to induce nausea and emesis in animal models. The cytotoxic properties of cisplatin also cause adverse events that negatively impact on animal welfare preventing repeated administration of cisplatin. In this study, we assessed whether a low (subclinical) dose of cisplatin could be utilized as a model of nausea and emesis in the dog while decreasing the severity of adverse events to allow repeated administration. The emetic, nausea-like behavior and potential biomarker response to both the clinical dose (70 mg/m2) and low dose (15 mg/m2) of cisplatin was assessed. Plasma creatinine concentrations and granulocyte counts were used to assess adverse effects on the kidneys and bone marrow, respectively. Nausea-like behavior and emesis was induced by both doses of cisplatin, but the latency to onset was greater in the low-dose group. No significant change in plasma creatinine was detected for either dose groups. Granulocytes were significantly reduced compared with baseline (P = 0.000) following the clinical, but not the low-dose cisplatin group. Tolerability of repeated administration was assessed with 4 administrations of an 18 mg/m2 dose cisplatin. Plasma creatinine did not change significantly. Cumulative effects on the granulocytes occurred, they were significantly decreased (P = 0.03) from baseline at 3 weeks following cisplatin for the 4th administration only. Our results suggest that subclinical doses (15 and 18 mg/m2) of cisplatin induce nausea-like behavior and emesis but have reduced adverse effects compared with the clinical dose allowing for repeated administration in crossover studies
Applying neutral drift to the directed molecular evolution of a β-glucuronidase into a β-galactosidase: Two different evolutionary pathways lead to the same variant
<p>Abstract</p> <p>Background</p> <p>Directed protein evolution has been used to modify protein activity and research has been carried out to enhance the production of high quality mutant libraries. Many theoretical approaches suggest that allowing a population to undergo neutral selection may be valuable in directed evolution experiments.</p> <p>Findings</p> <p>Here we report on an investigation into the value of neutral selection in a classical model system for directed evolution, the conversion of the <it>E. coli </it>β-glucuronidase to a β-galactosidase activity. We find that neutral selection, i.e. selection for retaining glucuronidase activity, can efficiently identify the majority of sites of mutation that have been identified as beneficial for galactosidase activity in previous experiments. Each variant demonstrating increased galactosidase activity identified by our neutral drift experiments contained a mutation at one of four sites, T509, S557, N566 or W529. All of these sites have previously been identified using direct selection for beta galactosidase activity.</p> <p>Conclusions</p> <p>Our results are consistent with others that show that a neutral selection approach can be effective in selecting improved variants. However, we interpret our results to show that neutral selection is, in this case, not a more efficient approach than conventional directed evolution approaches. However, the neutral approach is likely to be beneficial when the resulting library can be screened for a range of related activities. More detailed statistical studies to resolve the apparent differences between this system and others are likely to be a fruitful avenue for future research.</p
Hypernovae and Other Black-Hole-Forming Supernovae
During the last few years, a number of exceptional core-collapse supernovae
(SNe) have been discovered. Their kinetic energy of the explosions are larger
by more than an order of magnitude than the typical values for this type of
SNe, so that these SNe have been called `Hypernovae'. We first describe how the
basic properties of hypernovae can be derived from observations and modeling.
These hypernovae seem to come from rather massive stars, thus forming black
holes. On the other hand, there are some examples of massive SNe with only a
small kinetic energy. We suggest that stars with non-rotating black holes are
likely to collapse "quietly" ejecting a small amount of heavy elements (Faint
supernovae). In contrast, stars with rotating black holes are likely to give
rise to very energetic supernovae (Hypernovae). We present distinct
nucleosynthesis features of these two types of "black-hole-forming" supernovae.
Hypernova nucleosynthesis is characterized by larger abundance ratios
(Zn,Co,V,Ti)/Fe and smaller (Mn,Cr)/Fe. Nucleosynthesis in Faint supernovae is
characterized by a large amount of fall-back. We show that the abundance
pattern of the most Fe deficient star, HE0107-5240, and other extremely
metal-poor carbon-rich stars are in good accord with those of
black-hole-forming supernovae, but not pair-instability supernovae. This
suggests that black-hole-forming supernovae made important contributions to the
early Galactic (and cosmic) chemical evolution.Comment: 49 pages, to be published in "Stellar Collapse" (Astrophysics and
Space Science; Kluwer) ed. C. L. Fryer (2003
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