2D and 3D Core-Collapse Supernovae Simulation Results Obtained with the CHIMERA Code

Much progress in realistic modeling of core-collapse supernovae has occurred recently through the availability of multi-teraflop machines and the increasing sophistication of supernova codes. These improvements are enabling simulations with enough realism that the explosion mechanism, long a mystery, may soon be delineated. We briefly describe the CHIMERA code, a supernova code we have developed to simulate core-collapse supernovae in 1, 2, and 3 spatial dimensions. We then describe the results of an ongoing suite of 2D simulations initiated from a 12, 15, 20, and 25 solar mass progenitor. These have all exhibited explosions and are currently in the expanding phase with the shock at between 5,000 and 20,000 km. We also briefly describe an ongoing simulation in 3 spatial dimensions initiated from the 15 solar mass progenitor.Comment: 5 pages, 3 figure

Rationale for prostaglandin I2 in bone marrow oedema – from theory to application

Introduction: Bone marrow oedema (BME) and avascular osteonecrosis (AVN) are disorders of unclear origin. Although there are numerous operative and non-operative treatments for AVN, pain management in patients with AVN remains challenging. Prostaglandins play an important role in inflammatory responses and cell differentiation. It is thought that prostaglandin I2 ([PGI2] or synonoma prostacyclin) and its analogues promote bone regeneration on a cellular or systemic level. The purpose of this study was to assess the curative and symptomatic efficacy of the prostacyclin analogue iloprost in BME and AVN patients. Method: We are reporting on 50 patients (117 bones) affected by BME/AVN who were treated with iloprost. Pain levels before, during and 3 and 6 months after iloprost application were evaluated by a visual analogue scale (VAS). The short form(SF)-36 health survey served to judge general health status before and after treatment. Harris Hip Score (HHS) and Knee Society Score (KSS) were performed as functional scores and MRI and X-rays before and 3 and 6 months after iloprost application served as objective parameters for morphological changes of the affected bones. Results: We found a significant improvement in pain, functional and radiological outcome in BME and early AVN stages after iloprost application, whereas patients with advanced AVN stages did not benefit from iloprost infusions. Mean pain level decreased from 5.26 (day 0) to 1.63 (6 months) and both HHS and KSS increased during follow-up. Moreover, the SF-36 increased from 353.2 (day 0) to 560.5 points (6 months). We found a significant decrease in BME on MRI scans after iloprost application. Conclusions: In addition to other drugs, iloprost may be an alternative substance which should be considered in the treatment of BME/AVN-associated pain

Modeling core collapse supernovae in 2 and 3 dimensions with spectral neutrino transport

The overwhelming evidence that the core collapse supernova mechanism is inherently multidimensional, the complexity of the physical processes involved, and the increasing evidence from simulations that the explosion is marginal presents great computational challenges for the realistic modeling of this event, particularly in 3 spatial dimensions. We have developed a code which is scalable to computations in 3 dimensions which couples PPM Lagrangian with remap hydrodynamics [1], multigroup, flux-limited diffusion neutrino transport [2], with many improvements), and a nuclear network [3]. The neutrino transport is performed in a ray-by-ray plus approximation wherein all the lateral effects of neutrinos are included (e.g., pressure, velocity corrections, advection) except the transport. A moving radial grid option permits the evolution to be carried out from initial core collapse with only modest demands on the number of radial zones. The inner part of the core is evolved after collapse along with the rest of the core and mantle by subcycling the lateral evolution near the center as demanded by the small Courant times. We present results of 2-D simulations of a symmetric and an asymmetric collapse of both a 15 and an 11 M progenitor. In each of these simulations we have discovered that once the oxygen rich material reaches the shock there is a synergistic interplay between the reduced ram pressure, the energy released by the burning of the shock heated oxygen rich material, and the neutrino energy deposition which leads to a revival of the shock and an explosion.Comment: 10 pages, 3 figure

Vascular Imaging Using MR Angiography. (MR-Angiografie zur Gefäßdiagnostik).

Contrast enhanced magnetic resonance angiography (MRA) with gadolinium containing contrast media has evolved to a standard non-invasive imaging modality. High quality 3D vessel reconstructions can be acquired using conventional MR scanners together with body surface coils and 3D gradient sequences. The predominant indications for MRAs lie in the diagnostics, planning of vascular interventions and surgery of patients suffering from peripheral artery disease. With high sensitivity and specificity clinically relevant stenoses can be detected and collateral vessels identified. Methodological limitations mainly lie in the imaging of small and peripheral arteries and stented segments. The most important contraindications comprise conventional cardiac pacemakers, implantable defibrillators, paramagnetic implants, and 1st trimester pregnancy. Furthermore, in patients with severe renal failure (glomerular filtration rate of less than 30 ml/min/1.73 m2) gadolinium containing contrast medium should not be used as these patients are at increased risk of development of nephrogenic systemic fibrosis for which no treatment exists. Novel contrast free MRA techniques (e.g. QISS) have been developed and are currently under clinical validation but are not yet widely available

Assessment of early cartilage degeneration after slipped capital femoral epiphysis using T2 and T2* mapping

T2 and T2* mapping are novel tools to assess cartilage quality