AMIODARONE ET FONCTION THYROIDIENNE

Amiodarone is a drug which is frequently used in cardiology, and which can lead to the appearance of hyper or hypo thyroidism in certain cases. A study of the various parameters of thyroid function has shown that these are abnormal in every case treated by this drug, without the biochemical abnormalities necessarily being reflected clinically. The authors outline a method which will allow a distinction to be drawn between patients with a true thyroid malfunction and those whose biochemical results do not appear at first sight to be of any consequence. Regular assays of the total triiodothyronine (T3RIA) level are suggested as a means of early detection of thyroid malfunction in patients undergoing treatment with amiodarone.SCOPUS: NotDefined.jinfo:eu-repo/semantics/publishe

The application of linear discriminant analysis in the diagnosis of thyroid diseases

The effectiveness of five in-vitro laboratory tests for differentiation between three thyroid functional states (EU, HYPO and HYPER thyroidism) has been determined by using statistical linear discriminant analysis. The optimal linear combination of laboratory tests obtained by means of linear discriminant analysis results in a better use of the information present in each test, so that the possible redundancy of tests can be assessed. In this context, some feature selection criteria were evaluated. It is shown that in this application only two laboratory tests are necessary to obtain a sufficiently high diagnostic effectiveness when linear discriminant analysis is applied. © 1978.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Compulsive writing in a demented alcoholic patient with frontal lobe hypoperfusion

info:eu-repo/semantics/publishe

'Low T3 syndrome' in patients chronically treated with an iodine-containing drug, amiodarone

Cardiac patients treated with the iodine-containing drug 'amiodarone' undergo a significant iodine overload which can last for months after the drug has been withdrawn. Some patients develop hyperthyroidism and others hypothyroidism. In the hyper- or hypothyroid patients, the indices of thyroid function are modified as usually observed in these situations. In the patients remaining euthyroid while taking amiodarone or after its withdrawal, but still under its influence as shown by the iodine overload, a 'low-T3 syndrome' is observed, this state being characterized by a high total T4, a low free T4, a normal T3 resin uptake, a low total T3, a normal free T3, a high r-T3 and a relative TSH-unresponsiveness to TRH.SCOPUS: ar.jFLWNAinfo:eu-repo/semantics/publishe