Anbefaling på valg av standarder/rammeverk for velferdsteknologi

Velferdsteknologi kan gi mange, uansett alder, mulighet for å bo hjemme under trygge forhold dersom man blir syk, behøver omsorg eller bare ønsker mulighet til å bo hjemme i en sen fase i livet

Holocene oscillations in temperature and salinity of the surface subpolar North Atlantic

The Atlantic meridional overturning circulation (AMOC) transports warm salty surface waters to high latitudes, where they cool, sink and return southwards at depth. Through its attendant meridional heat transport, the AMOC helps maintain a warm northwestern European climate, and acts as a control on the global climate. Past climate fluctuations during the Holocene epoch (~11,700 years ago to the present) have been linked with changes in North Atlantic Ocean circulation. The behaviour of the surface flowing salty water that helped drive overturning during past climatic changes is, however, not well known. Here we investigate the temperature and salinity changes of a substantial surface inflow to a region of deep-water formation throughout the Holocene. We find that the inflow has undergone millennial-scale variations in temperature and salinity (~3.5 °C and ~1.5 practical salinity units, respectively) most probably controlled by subpolar gyre dynamics. The temperature and salinity variations correlate with previously reported periods of rapid climate change. The inflow becomes more saline during enhanced freshwater flux to the subpolar North Atlantic. Model studies predict a weakening of AMOC in response to enhanced Arctic freshwater fluxes, although the inflow can compensate on decadal timescales by becoming more saline. Our data suggest that such a negative feedback mechanism may have operated during past intervals of climate change

Mitochondrial respiratory states and rate

As the knowledge base and importance of mitochondrial physiology to human health expands, the necessity for harmonizing the terminologyconcerning mitochondrial respiratory states and rates has become increasingly apparent. Thechemiosmotic theoryestablishes the mechanism of energy transformationandcoupling in oxidative phosphorylation. Theunifying concept of the protonmotive force providestheframeworkfordeveloping a consistent theoretical foundation ofmitochondrial physiology and bioenergetics.We followguidelines of the International Union of Pure and Applied Chemistry(IUPAC)onterminology inphysical chemistry, extended by considerationsofopen systems and thermodynamicsof irreversible processes.Theconcept-driven constructive terminology incorporates the meaning of each quantity and alignsconcepts and symbols withthe nomenclature of classicalbioenergetics. We endeavour to provide a balanced view ofmitochondrial respiratory control and a critical discussion on reporting data of mitochondrial respiration in terms of metabolic flows and fluxes.Uniform standards for evaluation of respiratory states and rates will ultimatelycontribute to reproducibility between laboratories and thussupport the development of databases of mitochondrial respiratory function in species, tissues, and cells.Clarity of concept and consistency of nomenclature facilitate effective transdisciplinary communication, education, and ultimately further discovery

Mitochondrial physiology

As the knowledge base and importance of mitochondrial physiology to evolution, health and disease expands, the necessity for harmonizing the terminology concerning mitochondrial respiratory states and rates has become increasingly apparent. The chemiosmotic theory establishes the mechanism of energy transformation and coupling in oxidative phosphorylation. The unifying concept of the protonmotive force provides the framework for developing a consistent theoretical foundation of mitochondrial physiology and bioenergetics. We follow the latest SI guidelines and those of the International Union of Pure and Applied Chemistry (IUPAC) on terminology in physical chemistry, extended by considerations of open systems and thermodynamics of irreversible processes. The concept-driven constructive terminology incorporates the meaning of each quantity and aligns concepts and symbols with the nomenclature of classical bioenergetics. We endeavour to provide a balanced view of mitochondrial respiratory control and a critical discussion on reporting data of mitochondrial respiration in terms of metabolic flows and fluxes. Uniform standards for evaluation of respiratory states and rates will ultimately contribute to reproducibility between laboratories and thus support the development of data repositories of mitochondrial respiratory function in species, tissues, and cells. Clarity of concept and consistency of nomenclature facilitate effective transdisciplinary communication, education, and ultimately further discovery

Mitochondrial physiology

As the knowledge base and importance of mitochondrial physiology to evolution, health and disease expands, the necessity for harmonizing the terminology concerning mitochondrial respiratory states and rates has become increasingly apparent. The chemiosmotic theory establishes the mechanism of energy transformation and coupling in oxidative phosphorylation. The unifying concept of the protonmotive force provides the framework for developing a consistent theoretical foundation of mitochondrial physiology and bioenergetics. We follow the latest SI guidelines and those of the International Union of Pure and Applied Chemistry (IUPAC) on terminology in physical chemistry, extended by considerations of open systems and thermodynamics of irreversible processes. The concept-driven constructive terminology incorporates the meaning of each quantity and aligns concepts and symbols with the nomenclature of classical bioenergetics. We endeavour to provide a balanced view of mitochondrial respiratory control and a critical discussion on reporting data of mitochondrial respiration in terms of metabolic flows and fluxes. Uniform standards for evaluation of respiratory states and rates will ultimately contribute to reproducibility between laboratories and thus support the development of data repositories of mitochondrial respiratory function in species, tissues, and cells. Clarity of concept and consistency of nomenclature facilitate effective transdisciplinary communication, education, and ultimately further discovery

Activation of N-heterocyclic carbenes by {BeH₂} and {Be(H)(Me)} fragments

A stable three-coordinate dimethylberyllium species coordinated by the 1,3-bis­(2,4,6-trimethylphenyl)­imidazol-2-ylidene (IMes) ligand is readily converted to the corresponding methylhydrido derivative through metathetical reaction with phenylsilane. Attempts to synthesize the corresponding molecular dihydrides are, however, unsuccessful and result in ring opening of an IMes ligand through hydride transfer to the donor carbon atom and the consequent formation of a heterocyclic beryllium organoamide. In agreement with previous calculations, we suggest that this process occurs via a Schlenk-type equilibration process and formation of a four-coordinate bis-NHC beryllium dihydride. These species are not observed, however, as the steric pressure exerted by coordination of the two sterically demanding IMes ligands is sufficient to induce hydride transfer. The latter deduction is supported by the observation that a similar ring-opened product, but derived from methyl and hydride transfer, is available through the introduction of a further equivalent of IMes to the isolated beryllium methyl hydride species. In the latter case the ring-opening process is more facile, which we ascribe to the increased steric pressure achieved upon the formation of four-coordinate beryllium. In a further striking reaction under more forcing thermal conditions, the carbene carbon center of an IMes ligand is observed to be completely eliminated with selective formation of a three-coordinate diamidoberyllium species

Professional Service Automation verktøy for Nor IT

I rapporten beskriver vi fremgangen og prosessene vi har vært gjennom under utviklingen av Nor IT sitt Professional Services Automation (PSA)-system, vi går også inn på ulike verktøy og metoder vi har tatt i bruk for gjennomføring av selve prosjektet. Vi har fått en del frihet når det kommer til hvordan systemet skal se ut og hvordan det skal operere av oppdragsgiver Olav. Dette har gitt oss muligheten til å utfordre kreativitet når det kommer til problemløsning og oppretting av ulike funksjoner og hvordan vi tenker at systemet skal utvikles. Vi har sammen med dette fulgt generelle retningslinjer og inputs som oppdragsgiver Olav skulle ha underveis. Vi utvikler et PSA-system som har til hensikt å gjøre hverdagen for de ansatte ved Nor IT lettere. Systemet skal i teorien være et verktøy de ansatte kan benytte for å gjøre kundebehandlingsprosessene raskere og mer effektiv. For øyeblikket foregår mye av arbeidet manuelt gjennom epost og forskjellige portaler. I systemet vi designer ønsker vi å samle mye av funksjonaliteten Nor IT benytter seg av på en og samme plass, derav gjøre hverdagen mer effektiv for den ansatte. Gjennom de tre årene vi har vært på Universitet i Sørøst-Norge (USN) har vi hatt et tett samarbeid, og den arbeidsmetodikken som vi har best erfaring med er Scrumban som er en blanding av arbeidsmetodene Scrum og Kanban (går litt mer i dybden på det senere i rapporten). Kort forklart lager vi en liste over oppgaver som trengs å gjøres deretter tar vi oppgaver fra en tavle (ClickUp), og når vi er ferdige med oppgaven markerer vi den som «løst» eller «ferdig». Når det kommer til utfordringer og læring vi har hatt underveis i faget BOP3000, ønsker vi først å se litt på hvordan vi foretok risikovurderinger, for eksempel i henhold til Application Program Interface (API). Det viste seg å være lærerikt for vår del, ettersom uventede problemer dukket opp underveis i forbindelse med arbeid mot API-et til Fiken. Motivasjonen innad i gruppen har holdt seg på et godt nivå, men har hatt småperioder der den har duppet litt. Dette er noe vi tenker ikke er uvanlig og kan forekomme når man jobber på prosjekter som strekker seg over mange måneder. Dette er noe vi lærer av og tar med oss videre. En av tingene som har vært med på å gi oss motivasjon er møtene med veileder og oppdragsgiver. Vi føler vi har fått gode tilbakemeldinger fra begge to og det har gitt oss nytt pågangsmot og driv

Anbefaling på valg av standarder/rammeverk for velferdsteknologi

Velferdsteknologi kan gi mange, uansett alder, mulighet for å bo hjemme under trygge forhold dersom man blir syk, behøver omsorg eller bare ønsker mulighet til å bo hjemme i en sen fase i livet