420 research outputs found
A45 INDIRECT COMPARISON OF CLINICAL EFFICACY ACROSS COCHRANE REVIEWED PHYSIOTHERAPY INTERVENTIONS FOR PATIENTS WITH OSTEOARTHRITIS: A META-ANALYSIS WITH MIXED TREATMENT COMPARISONS
Intra-articular treatment of hip osteoarthritis: a randomized trial of hyaluronic acid, corticosteroid, and isotonic saline
SummaryObjectiveHyaluronic acid (HA) and corticosteroids are both widely used for intra-articular treatment of knee osteoarthritis (OA). We examined the effect of both drugs in intra-articular treatment for hip OA.MethodsOne hundred and one patients with hip OA were included in a prospective double blind study, using a randomized controlled trial with a three-armed parallel-group design. Three ultrasound-guided, intra-articular injections were given at 14 days interval. The primary outcome measure was âpain on walkingâ, registered on a visual analogue scale (VAS). Evaluation was performed at baseline and after 14, 28 and 90 days. The study adhered to the Consolidated Standards of Reporting Trials. All analyses were based on intention-to-treat analyses, and used âmixed-proceduresâ with the baseline-observation as covariate.ResultsThere were no significant interactions with respect to TreatmentĂTime for any of the analyzed outcome measures. There was a significant treatment effect for âpain on walkingâ (P=0.044) due to a significant improvement following corticosteroid compared to saline with an effect-size of 0.6 (95% confidence interval: 0.1â1.1, P=0.021). By contrast, HA compared to saline had an effect size of 0.4 (â0.1 to 0.9; P=0.13). The peak-effect was obtained after 2 weeks. There was no difference between the treatment groups at endpoint. No significant side effects of the injections were observed.ConclusionsPatients treated with corticosteroids experienced significant improvement during the 3 months of intervention, with an effect size indicating a moderate clinical effect. Although a similar significant result following treatment with HA could not be shown, the effect size indicated a small clinical improvement. A higher number of patients in future HA studies would serve to clarify this point
Survival on controlled-release morphine versus controlled-release oxycodone in opioid-naĂŻve patients with non-malignant pain: data from Danish national health registers
Efficacy and safety of ginger in osteoarthritis patients: a systematic review and meta-analysis of randomized placebo-controlled trials
Cardiovascular risk factor changes following three different maintenance programs in obese knee osteoarthritis patients after a major weight loss: a randomized controlled trial
Is increased joint loading detrimental to obese patients with knee osteoarthritis? A secondary data analysis from a randomized trial
SummaryObjectiveTo investigate whether increased knee joint loading due to improved ambulatory function and walking speed following weight loss achieved over 16 weeks accelerates symptomatic and structural disease progression over a subsequent 1 year weight maintenance period in an obese population with knee osteoarthritis (OA).MethodsData from a prospective study of weight loss in obese patients with knee OA (the CARtilage in obese knee OsteoarThritis (CAROT) study) were used to determine changes in knee joint compressive loadings (model estimated) during walking after a successful 16 week weight loss intervention. The participants were divided into âUnloadersâ (participants that reduced joint loads) and âLoadersâ (participants that increased joint loads). The primary symptomatic outcome was changes in knee symptoms, measured with the Knee injury and Osteoarthritis Outcome Score (KOOS) questionnaire, during a subsequent 52 weeks weight maintenance period. The primary structural outcome was changes in tibiofemoral cartilage loss assessed semi-quantitatively (Boston Leeds Knee Osteoarthritis Score (BLOKS) from MRI after the 52 weight maintenance period.Results157 participants (82% of the CAROT cohort) with medial and/or lateral knee OA were classified as Unloaders (n = 100) or Loaders (n = 57). The groups showed similar significant changes in symptoms (group difference: â2.4 KOOS points [95% CI â6.8:1.9]) and cartilage loss (group difference: â0.06 BLOKS points [95% CI â0.22:0.11) after 1 year, with no statistically significant differences between Loaders and Unloaders.ConclusionFor obese patients undergoing a significant weight loss, increased knee joint loading for 1 year was not associated with accelerated symptomatic and structural disease progression compared to a similar weight loss group that had reduced ambulatory compressive knee joint loads.Clinicaltrials.govNCT00655941
Pain and pain mechanisms in patients with inflammatory arthritis:A Danish nationwide cross-sectional DANBIO registry survey
Comparing different preparations and doses of rosehip powder in patients with osteoarthritis of the knee: an exploratory randomized active-controlled trial
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