Aquatic exercise associated or not with grape juice consumption-modulated oxidative parameters in Parkinson disease patients : a randomized intervention study

Parkinson's disease (PD) is a neurodegenerative disorder with significant motor disabilities and cognitive decline. Importantly, the imbalance of oxidative stress is related to PD physiopathology and progression. This study aimed to evaluate the impact of grape juice consumption associated with an aquatic exercise protocol on oxidative stress parameters and cognitive function in individuals with PD. The participants were randomized into two groups: grape juice group (GJG) and control group (CG) and were submitted to 4 weeks of an aquatic intervention (twice a week, approximately 60 minutes/session). The GJG also consumed 400 ml of grape juice per day (integral and conventional) during this period. Cognitive function was assessed by the Montreal Cognitive Assessment (MoCa) questionnaire. For the analysis of oxidative stress markers, specifically lipid oxidative damage (TBARS), proteins (Carbonil), acid uric and the activity of antioxidant enzymes (superoxide dismutase, glutathione peroxidase and catalase), blood collection were done before and after intervention. No changes were observed in cognitive function after intervention in both groups. Regarding biomarkers, a reduction of antioxidant enzymes, thiobarbituric acid reactive substances (TBARS) and uric acid was observed in both groups. However, only the GJG showed a significant reduction on protein oxidation levels after intervention. In conclusion, the consumption of grape juice associated with an aquatic exercise protocol might be consider an effective alternative to reduce the oxidative damage in PD, reinforcing the importance of this intervention in promoting beneficial impact in this population

O metabolismo de apolipoproteínas e lipoproteínas na doença de Parkinson

Revisar os recentes avanços sobre o estudo do metabolismo de apolipoproteínas e lipoproteínas e sua associação na Doença de Parkinson (DP), a segunda doença neurodegenerativa mais comum que afeta principalmente a população idosa. Foi realizada uma revisão literária através de artigos científicos das bases de dados Pubmed, Science Direct, Scopus e Scielo. A seleção dos artigos considerou aqueles mais relevantes de acordo com a abrangência do tema proposto, de forma não sistemática. Foram selecionados 24 artigos entre 2010 a 2018 que discutiam DP com metabolismo de apolipoproteínas e lipoproteínas. Apoliproteinas e lipoproteínas podem contribuir como biomarcadores para o desenvolvimento, progressão e diagnóstico de DP, entretanto estudos adicionais são necessários para elucidar os mecanismos envolvidos na associação entre o metabolismo e o risco da doença