Electromagnetic emission of white dwarf binary mergers

It has been recently proposed that the ejected matter from white dwarf (WD) binary mergers can produce transient, optical and infrared emission similar to the "kilonovae" of neutron star (NS) binary mergers. To confirm this we calculate the electromagnetic emission from WD-WD mergers and compare with kilonova observations. We simulate WD-WD mergers leading to a massive, fast rotating, highly magnetized WD with an adapted version of the smoothed-particle-hydrodynamics (SPH) code Phantom. We thus obtain initial conditions for the ejecta such as escape velocity, mass and initial position and distribution. The subsequent thermal and dynamical evolution of the ejecta is obtained by integrating the energy-conservation equation accounting for expansion cooling and a heating source given by the fallback accretion onto the newly-formed WD and its magneto-dipole radiation. We show that magnetospheric processes in the merger can lead to a prompt, short gamma-ray emission of up to $\approx 10^{46}$ erg in a timescale of $0.1$-$1$ s. The bulk of the ejecta initially expands non-relativistically with velocity $0.01 c$ and then it accelerates to $0.1 c$ due to the injection of fallback accretion energy. The ejecta become transparent at optical wavelengths around $\sim 7$ days post-merger with a luminosity $10^{41}$-$10^{42}$ erg s$^{-1}$. The X-ray emission from the fallback accretion becomes visible around $\sim 150$-$200$ day post-merger with a luminosity of $10^{39}$ erg s$^{-1}$. We also predict the post-merger time at which the central WD should appear as a pulsar depending on the value of the magnetic field and rotation period.Comment: 12 pages, Accepted for publication in JCA

High-temperature anti-Invar behavior of gamma-Fe precipitates in Fe_xCu_(100-x) solid solutions: Ferromagnetic phases

High-temperature magnetization and neutron diffraction measurements on metastable Fe_xCu_(100-x) solid solutions have recently shown to imply that γ-Fe precipitates present ferromagnetic anti-Invar behavior. For this reason, we have studied the ferromagnetic phases of γ-Fe in moment-volume parameter space, using the general potential linearized-augmented plane-wave method and the fixed spin moment procedure in order to calculate the corresponding total energy. We find that only two ferromagnetic phases (one related to a low- spin state and the other to a high-spin state) can exist and even coexist in limited volume ranges (3.55-3.59 Å). Hence, our results provide a "revisited" version of the local spin density calculations used in the early article by Moruzzi [Phys. Rev. B 34, 1784 (1986)]. In addition, the fixed spin moment method-using an energy-moment-volume space representation-allows us to conclude that the high-spin state is the ground state of the gamma-Fe precipitates, as the anti-Invar behavior is an intrinsic property of these states. This simple scenario seems to adequately describe the perplexing phenomenology recently observed on Fe_xCu_(100-x) solid solutions

Strings at the bottom of the deformed conifold

We present solutions of the equations of motion of macroscopic F and D strings extending along the non compact 4D sections of the conifold geometry and winding around the internal directions. The effect of the Goldstone modes associated with the position of the strings on the internal manifold can be seen as a current on the string that prevents it from collapsing and allows the possibility of static 4D loops. Its relevance in recent models of brane inflation is discussed.Comment: 9+1 page

Chirping compact stars: gravitational radiation and detection degeneracy with binary systems A conceptual pathfinder for space-based gravitational-wave observatories

Compressible, Riemann S-type ellipsoids can emit gravitational waves (GWs) with a chirp-like behavior (hereafter chirping ellipsoids, CELs). We show that the GW frequency-amplitude evolution of CELs (mass $\sim 1$~M$_\odot$, radius $\sim10^3$~km, polytropic equation of state with index $n\approx 3$) is indistinguishable from that emitted by double white dwarfs (DWDs) and by extreme mass-ratio inspirals (EMRIs) composed of an intermediate-mass (e.g.~$10^3~M_\odot$) black hole and a planet-like (e.g.~$10^{-4}~M_\odot$) companion, in a specific frequency interval within the detector sensitivity band in which the GWs of all these systems are quasi-monochromatic. We estimate that for reasonable astrophysical assumptions, the rates in the local Universe of CELs, DWDs and EMRIs in the mass range considered here, are very similar, posing a detection-degeneracy challenge for space-based GW detectors. The astrophysical implications of this CEL-binary detection degeneracy by space-based GW-detection facilities, are outlined.Comment: Submitted to Phys. Rev.

Training concerning the protection of animals used for experimentation scientific and educational purposes. Regulatory aspects

Resúmenes IV Congreso VetDoc de Docencia Veterinaria, León 2017 (6-7 de Julio)[ES] La utilización de animales para investigación y docencia con el objetivo de obtener información y datos relevantes para la ciencia ha generado una gran controversia ética desde finales del siglo XIX. Asumiendo la necesidad de utilizar animales para estos fines los países europeos han desarrollado un amplio corpus legislativo ya que entre las disposiciones de la Unión Europea se encuentra la obligación de los Estados Miembros de aplicar la protección/Bienestar Animal en las políticas de investigación y desarrollo tecnológico

Binding site plasticity in viral PPxY Late domain recognition by the third WW domain of human NEDD4

The recognition of PPxY viral Late domains by the third WW domain of the HECT-E3 ubiquitin ligase NEDD4 (hNEDD4-WW3) is essential for the completion of the budding process of numerous enveloped viruses, including Ebola, Marburg, HTLV1 or Rabies. hNEDD4-WW3 has been validated as a promising target for the development of novel host-oriented broad spectrum antivirals. Nonetheless, finding inhibitors with good properties as therapeutic agents remains a challenge since the key determinants of binding affinity and specificity are still poorly understood. We present here a detailed structural and thermodynamic study of the interactions of hNEDD4-WW3 with viral Late domains combining isothermal titration calorimetry, NMR structural determination and molecular dynamics simulations. Structural and energetic differences in Late domain recognition reveal a highly plastic hNEDD4-WW3 binding site that can accommodate PPxY-containing ligands with varying orientations. These orientations are mostly determined by specific conformations adopted by residues I859 and T866. Our results suggest a conformational selection mechanism, extensive to other WW domains, and highlight the functional relevance of hNEDD4-WW3 domain conformational flexibility at the binding interface, which emerges as a key element to consider in the search for potent and selective inhibitors of therapeutic interest.This research has been financed by grants BIO2009-13261-C02, BIO2012-39922-CO2 and BIO2016-78746-C2-1-R from the Spanish Ministry of Education and Science (I.L.) including AEI/FEDER EU funds, by CTQ2017-83810-R grant (F.J.B) and by BFU2014-53787-P, the IRB Barcelona and the BBVA Foundation (M.J.M)

Incidents control in radiotherapy oncology

Primer pla de l'escut del monarca del s. XVI, conservat i ubicat a la porta de la UB. Mesura 1,60 x 2,20 metre si és de pedra sorrenca

Evaluation of the bovine ATP-binding cassette subfamily A member 13 (ABCA13) as a potential biomarker for sensitive detection of animals with focal pathological forms of subclinical paratuberculosis

Trabajo presentado al: ICP 15th International Association for Paratuberculous, Dublín, 12-16 Junio. 2022.Peer reviewe

Use of ATP-Binding cassette Subfamily A Member 13 (ABCA13) for sensitive detection of focal pathological forms of subclinical bovine paratuberculosis

14 páginas, 4 tablas, 3 figuras.Bovine paratuberculosis (PTB) is a chronic enteritis caused by Mycobacterium avium subspecies paratuberculosis (Map) that causes a heavy economic impact worldwide. Map infected animals can remain asymptomatic for years while transmitting the mycobacteria to other members of the herd. Therefore, accurate detection of subclinically infected animals is crucial for disease control. In a previous RNA-Seq study, we identified several mRNAs that were overexpressed in whole blood of cows with different PTB-associated histological lesions compared with control animals without detected lesions. The proteins encoded by two of these mRNAs, ATP binding cassette subfamily A member 13 (ABCA13) and Matrix Metallopeptidase 8 (MMP8) were significantly overexpressed in whole blood of animals with focal histological lesions, the most frequent pathological form in the subclinical stages of the disease. In the current study, the potential of sensitive early diagnostic tools of commercial ELISAs, based on the detection of these two biomarkers, was evaluated in serum samples of 704 Holstein Friesian cows (566 infected animals and 138 control animals from PTB-free farms). For this evaluation, infected animals were classified into three groups, according to the type of histological lesions present in their gut tissues: focal (n = 447), multifocal (n = 59), and diffuse (n = 60). The ELISA based on the detection of ABCA13 was successfully validated showing good discriminatory power between animals with focal lesions and control animals (sensitivity 82.99% and specificity 80.43%). Conversely, the MMP8-based ELISA showed a poor discriminatory power between the different histological groups and non-infected controls. The ABCA13-based ELISA showed a higher diagnostic value (0.822) than the IDEXX ELISA (0.517), the fecal bacterial isolation (0.523) and the real-time PCR (0.531) for the detection of animals with focal lesions. Overall, our results indicate that this ABCA13 ELISA greatly improves the identification of subclinically infected animals with focal lesions that are undetectable using current diagnostic methods.This study was part of the I+D+i project (RTI2018- 094192-R-C22) and was funded by the Spanish MCIN/AEI/10.13039/501100011033/ Ministry of Science, Innovation and the European Regional Development Funds (FEDER Una manera de hacer Europa) and by the Gobierno del Principado de Asturias, Regional funds PCTI 2021– 2023 (GRUPIN: IDI2021-000102) co-funded by FEDER. We acknowledge the National Institute for Agricultural Research (INIA) for the scholarships of CB-V (Ayuda CPD2016-0142 financiada por MCIN/AEI/ 10.13039/501100011033 y FSE El FSE invierte en tu future) and MC.Peer reviewe