Clinical Features And Laboratory Patterns In A Cohort Of Consecutive Argentinian Patients With Von Willebrand's Disease

Background and Objectives. von Willebrand's disease (vWD) is a bleeding disorder with variable clinical expression. Our aim was to classify patients with vWD and to determine the phenotype in their relatives. Design and Methods. The types and subtypes, blood group frequency and its relevance, bleeding sites, response to the desmopressin (DDAVP) test, transfusion requirements and clinical features in type 1 and 2A families were determined in 1,885 patients. Results. Our findings were: type 1: 91%, type 2A: 3.1%, severe vWD: 1.3%; type 2N: 1.6%; type low intraplatelet: 2.7%; combined 1+2N: 0.3%. Blood group O prevalence was 70.5%. Bleeding and transfusion requirements were not correlated to blood groups. The most frequent symptoms were: ecchymoses-hematomas and epistaxis and, in females over 13 years, also menorrhagia. Normal levels of factor VIII:C were found in 38.4% of the patients. DDAVP was infused in 567 patients with a good response in 80.6%. About 9% of our patients needed transfusion therapy. The diagnosis of von Willebrand’s disease is more likely in subjects belonging to families with type 2A disease than in members of families with type 1 vWD in spite of these being symptomatic. Interpretation and Conclusions. These observations provide a good strategy to identify, classify and treat vWD patients without performing molecular assays.Fil: Woods, Adriana Inés. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Academia Nacional de Medicina de Buenos Aires; ArgentinaFil: Meschengieser, S. S.. Academia Nacional de Medicina de Buenos Aires; ArgentinaFil: Blanco, A. N.. Academia Nacional de Medicina de Buenos Aires; ArgentinaFil: Salviu, M. J.. Academia Nacional de Medicina de Buenos Aires; ArgentinaFil: Farias, Cristina Elena. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Academia Nacional de Medicina de Buenos Aires; ArgentinaFil: Kempfer, Ana Catalina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Academia Nacional de Medicina de Buenos Aires; ArgentinaFil: Lazzari, María Ángela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Academia Nacional de Medicina de Buenos Aires; Argentin

Brane Bremsstrahlung in DBI Inflation

We consider the effect of trapped branes on the evolution of a test brane whose motion generates DBI inflation along a warped throat. The coupling between the inflationary brane and a trapped brane leads to the radiation of non-thermal particles on the trapped brane. We calculate the Gaussian spectrum of the radiated particles and their backreaction on the DBI motion of the inflationary brane. Radiation occurs for momenta lower than the speed of the test brane when crossing the trapped brane. The slowing down effect is either due to a parametric resonance when the interaction time is small compared to the Hubble time or a tachyonic resonance when the interaction time is large. In both cases the motion of the inflationary brane after the interaction is governed by a chameleonic potential,which tends to slow it down. We find that a single trapped brane can hardly slow down a DBI inflaton whose fluctuations lead to the Cosmic Microwave Background spectrum. A more drastic effect is obtained when the DBI brane encounters a tightly spaced stack of trapped branes.Comment: 20 pages, 1 figur

Validity of water industry wastes in cement industry

This paper examines the validity of several water industry wastes to be reused in different stages of cement production. The wastes considered are: a drinking water treatment plant sludge (DWTP), a sewage sludge (SS) and a spent activated carbon. Different procedures of drying of wastes using a novel dry spray system or subjected to thermal drying or stabilization and dried with lime are analysed. The spray drying process was successfully used with the DWTP sludge (but not with SS). The material was not found to be suitable as a supplementary material in blended cements. Despite this, the spray dried sludge did show good potential as partial or full substitute for clay as a raw material in cement clinker manufacture. A novel thermally drying process (Turbo-drying RINA-JET) was applied to produce dried sewage sludge. The dry sludge consisted of 56 % organic matter and has a high calorific value (8291 J / g), making it valid as an alternative fuel. The ash (35% of dry SS) contains Ca, Fe, P, Si and Al as main inorganic elements which are incorporated into the clinker phases. The burnability of the raw mixture containing this SS sludge was better than in the control raw mix. Furthermore, the paper describes an industrial process for stabilising sewage sludge (SS) with lime and evaluates the viability of the stabilised product, referred to as “Neutral”, as a raw material in the production of Portland cement clinker for the cement industry. The proposed process for sewage sludge treatment has a number of advantages over traditional treatments. In the Basic plant design, the chemical energy in the reagents generates sufficient thermal energy for the moisture to evaporate. This makes the process more energy-efficient than others. The validity of the “Neutral” product as a starting material in raw mixes for the production of cement clinker by substitution of limestone is demonstrated. Regarding the validity of spent activated carbon as an alternative to pet coke as fuel in Portland cement kilns, the carbon differed substantially from the coke, having lower calorific value (18 % less). However, the qualities of the spent coke were still sufficient for the intended use. The ash fraction of the spent activated carbon was mainly composed of anhydrite and quartz (SO3 = 14.1 %) and it is included into the clinker phases during the burning. The SO3 from the ashes promotes a very large growth in alite crystals in the clinker

Strings at the bottom of the deformed conifold

We present solutions of the equations of motion of macroscopic F and D strings extending along the non compact 4D sections of the conifold geometry and winding around the internal directions. The effect of the Goldstone modes associated with the position of the strings on the internal manifold can be seen as a current on the string that prevents it from collapsing and allows the possibility of static 4D loops. Its relevance in recent models of brane inflation is discussed.Comment: 9+1 page

The AMBRE Project: searching for the closest solar siblings

Finding solar siblings, that is, stars that formed in the same cluster as the Sun, will yield information about the conditions at the Sun's birthplace. We search for solar sibling candidates in AMBRE, the very large spectra database of solar vicinity stars. Since the ages and chemical abundances of solar siblings are very similar to those of the Sun, we carried out a chemistry- and age-based search for solar sibling candidates. We used high-resolution spectra to derive precise stellar parameters and chemical abundances of the stars. We used these spectroscopic parameters together with Gaia DR2 astrometric data to derive stellar isochronal ages. Gaia data were also used to study the kinematics of the sibling candidates. From the about 17000 stars that are characterized within the AMBRE project, we first selected 55 stars whose metallicities are closest to the solar value (-0.1 < [Fe/H] < 0.1 dex). For these stars we derived precise chemical abundances of several iron-peak, alpha- and neutron-capture elements, based on which we selected 12 solar sibling candidates with average abundances and metallicities between -0.03 to 0.03 dex. Our further selection left us with 4 candidates with stellar ages that are compatible with the solar age within observational uncertainties. For the 2 of the hottest candidates, we derived the carbon isotopic ratios, which are compatible with the solar value. HD186302 is the most precisely characterized and probably the most probable candidate of our 4 best candidates. Very precise chemical characterization and age estimation is necessary to identify solar siblings. We propose that in addition to typical chemical tagging, the study of isotopic ratios can give further important information about the relation of sibling candidates with the Sun. Ideally, asteroseismic age determinations of the candidates could solve the problem of imprecise isochronal ages.Comment: Accepted for publication in A&

Preheating After Modular Inflation

We study (p)reheating in modular (closed string) inflationary scenarios, with a special emphasis on Kahler moduli/Roulette models. It is usually assumed that reheating in such models occurs through perturbative decays. However, we find that there are very strong non-perturbative preheating decay channels related to the particular shape of the inflaton potential (which is highly nonlinear and has a very steep minimum). Preheating after modular inflation, proceeding through a combination of tachyonic instability and broad-band parametric resonance, is perhaps the most violent example of preheating after inflation known in the literature. Further, we consider the subsequent transfer of energy to the standard model sector in scenarios where the standard model particles are confined to a D7-brane wrapping the inflationary blow-up cycle of the compactification manifold or, more interestingly, a non-inflationary blow up cycle. We explicitly identify the decay channels of the inflaton in these two scenarios. We also consider the case where the inflationary cycle shrinks to the string scale at the end of inflation; here a field theoretical treatment of reheating is insufficient and one must turn instead to a stringy description. We estimate the decay rate of the inflaton and the reheat temperature for various scenarios.Comment: 34 pages, 10 figures. Accepted for publication in JCA

Impact of urine and mixed incontinence on long-term care preference: a vignette-survey study of community-dwelling older adults.

In view of population aging, a better knowledge of factors influencing the type of long-term care (LTC) among older adults is necessary. Previous studies reported a close relationship between incontinence and institutionalization, but little is known on opinions of older citizens regarding the most appropriate place of care. This study aimed at evaluating the impact of urine and/or fecal incontinence on preferences of community-dwelling older citizens. We derived data from the Lausanne cohort 65+, a population-based study of individuals aged from 68 to 82 years. A total of 2974 community-dwelling persons were interviewed in 2017 on the most appropriate place of LTC delivery for three vignettes displaying a fixed level of disability with varying degrees of incontinence (none, urinary, urinary and fecal). Multinomial logistic regression analyses explored the effect of respondents' characteristics on their opinion according to Andersen's model. The level of incontinence described in vignettes strongly determined the likelihood of considering institutional care as most appropriate. Respondents' characteristics such as age, gender, educational level, being a caregiver, knowledge of shelter housing or feeling supported by family influenced LTC choices. Self-reported incontinence and other indicators of respondents' need, however, had no significant independent effect. Among older community-dwelling citizens, urinary and fecal incontinence play a decisive role in the perception of a need for institutionalization. Prevention and early initiation of support for sufferers may be a key to prevent this need and ensure familiar surrounding as long as possible

Anisotropic Inflation with Non-Abelian Gauge Kinetic Function

We study an anisotropic inflation model with a gauge kinetic function for a non-abelian gauge field. We find that, in contrast to abelian models, the anisotropy can be either a prolate or an oblate type, which could lead to a different prediction from abelian models for the statistical anisotropy in the power spectrum of cosmological fluctuations. During a reheating phase, we find chaotic behaviour of the non-abelian gauge field which is caused by the nonlinear self-coupling of the gauge field. We compute a Lyapunov exponent of the chaos which turns out to be uncorrelated with the anisotropy.Comment: 16 pages, 4 figure

Amenability of algebras of approximable operators

We give a necessary and sufficient condition for amenability of the Banach algebra of approximable operators on a Banach space. We further investigate the relationship between amenability of this algebra and factorization of operators, strengthening known results and developing new techniques to determine whether or not a given Banach space carries an amenable algebra of approximable operators. Using these techniques, we are able to show, among other things, the non-amenability of the algebra of approximable operators on Tsirelson's space.Comment: 20 pages, to appear in Israel Journal of Mathematic

Optimizing the capture of protein interaction partners in the biacore T100 for mapping signaling pathways with low cell amounts

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