Gemfibrozil Inhibits Legionella pneumophila and Mycobacterium tuberculosis Enoyl Coenzyme A Reductases and Blocks Intracellular Growth of These Bacteria in Macrophages

We report here that gemfibrozil (GFZ) inhibits axenic and intracellular growth of Legionella pneumophila and of 27 strains of wild-type and multidrug-resistant Mycobacterium tuberculosis in bacteriological medium and in human and mouse macrophages, respectively. At a concentration of 0.4 mM, GFZ completely inhibited L. pneumophila fatty acid synthesis, while at 0.12 mM it promoted cytoplasmic accumulation of polyhydroxybutyrate. To assess the mechanism(s) of these effects, we cloned an L. pneumophila FabI enoyl reductase homolog that complemented for growth an Escherichia coli strain carrying a temperature-sensitive enoyl reductase and rendered the complemented E. coli strain sensitive to GFZ at the nonpermissive temperature. GFZ noncompetitively inhibited this L. pneumophila FabI homolog, as well as M. tuberculosis InhA and E. coli FabI

Letter from Mrs. Phyllis Blanchard enquiring about driving lessons, 1929

A letter from Mrs Phyllis Blanchard, a new car owner, enquiring about whether Swinburne Technical College will be conducting driving lessons for ladies, 1929

The adolescent girl; a study from the psychoanalytic viewpoint,

London edition (K. Paul, Trench, Trubner & co., ltd.) has title: The care of the adolescent girl.The author's doctoral dissertation, Clark university, 1919, but not published as a thesis.Bibliography at end of each chapter.Mode of access: Internet