The CI-FLOW Project: A System for Total Water Level Prediction from the Summit to the Sea

Kildow et al. (2009) reported that coastal states support 81% of the U.S. population and generate 83 percent [$11.4 trillion (U.S. dollars) in 2007] of U.S. gross domestic product. Population trends show that a majority of coastal communities have transitioned from a seasonal, predominantly weekend, tourist-based economy to a year-round, permanently based, business economy where industry expands along shorelines and the workforce commutes from inland locations. As a result of this transition, costs associated with damage to the civil infrastructure and disruptions to local and regional economies due to coastal flooding events are escalating, pushing requirements for a new generation of flood prediction technologies and hydrologic decision support tools

Self-organisation in protoplanetary discs

Recent observations revealed organised structures in protoplanetary disks, such as axisymmetric rings or horseshoe concen- trations evocative of large-scale vortices. These structures are often interpreted as the result of planet-disc interactions. However, these disks are also known to be unstable to the magneto-rotational instability (MRI) which is believed to be one of the dominant angular momentum transport mechanism in these objects. It is therefore natural to ask if the MRI itself could produce these structures without invoking planets. The nonlinear evolution of the MRI is strongly affected by the low ionisation fraction in protoplanetary disks. The Hall effect in particular, which is dominant in dense and weakly ionised parts of these objects, has been shown to spontaneously drive self- organising flows in shearing box simulations. Here, we investigate the behaviour of global MRI-unstable disc models dominated by the Hall effect and characterise their dynamics. We perform 3D unstratified Hall-MHD simulations of keplerian disks for a broad range of Hall, ohmic and ambipolar Elsasser numbers. We confirm the transition from a turbulent to an organised state as the intensity of the Hall effect is increased. We observe the formation of zonal flows, their number depending on the available magnetic flux and on the intensity of the Hall effect. For intermediate Hall intensity, the flow self-organises into long-lived magnetised vortices. Neither the addition of a toroidal field nor ohmic or ambipolar diffusion drastically change this picture in the range of parameters we have explored. The ability of these structures to trap dust particles in this configuration is demonstrated. We conclude that Hall-MRI driven organisation is a plausible scenario which could explain some of the structures found in recent observations.Comment: 16 pages, 21 figure

Genome-wide Association Study Identifies 2 New Loci Associated With Anti-NMDAR Encephalitis

Background and Objectives To investigate the genetic determinants of the most common type of antibody-mediated autoimmune encephalitis, anti-NMDA receptor (anti-NMDAR) encephalitis. Methods We performed a genome-wide association study in 178 patients with anti-NMDAR encephalitis and 590 healthy controls, followed by a colocalization analysis to identify putatively causal genes. Results We identified 2 independent risk loci harboring genome-wide significant variants (p = 2.2), 1 on chromosome 15, harboring only the LRRK1 gene, and 1 on chromosome 11 centered on the ACP2 and NR1H3 genes in a larger region of high linkage disequilibrium. Colocalization signals with expression quantitative trait loci for different brain regions and immune cell types suggested ACP2, NR1H3, MADD, DDB2, and C11orf49 as putatively causal genes. The best candidate genes in each region are LRRK1, encoding leucine-rich repeat kinase 1, a protein involved in B-cell development, and NR1H3 liver X receptor alpha, a transcription factor whose activation inhibits inflammatory processes. Discussion This study provides evidence for relevant genetic determinants of antibody-mediated autoimmune encephalitides outside the human leukocyte antigen (HLA) region. The results suggest that future studies with larger sample sizes will successfully identify additional genetic determinants and contribute to the elucidation of the pathomechanism

Track Reconstruction with Cosmic Ray Data at the Tracker Integration Facility

The subsystems of the CMS silicon strip tracker were integrated and commissioned at the Tracker Integration Facility (TIF) in the period from November 2006 to July 2007. As part of the commissioning, large samples of cosmic ray data were recorded under various running conditions in the absence of a magnetic field. Cosmic rays detected by scintillation counters were used to trigger the readout of up to 15\,\% of the final silicon strip detector, and over 4.7~million events were recorded. This document describes the cosmic track reconstruction and presents results on the performance of track and hit reconstruction as from dedicated analyses