Integrating life cycle assessment tools and information with product life cycle management : Product data management

Part of: Seliger, Günther (Ed.): Innovative solutions : proceedings / 11th Global Conference on Sustainable Manufacturing, Berlin, Germany, 23rd - 25th September, 2013. - Berlin: Universitätsverlag der TU Berlin, 2013. - ISBN 978-3-7983-2609-5 (online). - http://nbn-resolving.de/urn:nbn:de:kobv:83-opus4-40276. - pp. 210–212.Integrating Product Data Management (PDM) solutions with Life Cycle Assessment (LCA) software offers the opportunity to obtain LCA results fast, based on high-quality, product-specific information and integrated into the design workflow, enabling thereby, inter alia, efficient Design for Environment (DfE). In a recent project, Dassault Systèmes and GreenDelta have investigated different options for combining LCA tools and information with the ENOVIA platform, a broadly used PDM and Product Life Cycle Management (PLM) platform by Dassault Systèmes. In the course of the project, solutions have been developed for main LCA software systems, including SimaPro, GaBi, EIME, and openLCA. A demonstration implementation has been performed for the openLCA software. A specific connector interface, called ‘eLCA’, was developed in the project; it provides an interface which makes it easy for LCA software to “dock” to eLCA that in turn links to the ENOVIA platform. The paper will describe the technical solution that has been developed and show its benefit and further potential

Changes in cortical [beta]-adrenergic receptor density and neuronal sensitivity to norepinephrine accompany morphine dependence and withdrawal

Radioligand binding experiments were carried out in conjunction with electrophysiological recordings in vivo in the parietal cortex in rats to assess changes in postsynaptic [beta]-adrenergic receptor function that result after chronic administration of morphine and during morphine withdrawal. Chronic treatment of rats with morphine for 14 days resulted in a 38% increase in the density of [beta]-adrenergic receptors in the parietal cortex, as measured by the binding of the specific antagonist [3H]dihydroalprenolol (DHA). In comparison, following withdrawal in the chronic morphine-treated animals, the number of specific [3H]DHA binding sites in this same cortical region was decreased 25%, when compared to saline-treated controls. These alterations in cortical [beta]-adrenergic receptor density were not accompanied by a significant change in the dissociation constant (Kd) for [3H]DHA or in the inhibitory constants (Ki) for the specific agonists norepinephrine and isoproterenol. Microiontophoretic testing revealed that the changes in [beta]-adrenergic receptor density found in parietal cortex after chronin morphine treatment and during morphine withdrawal were accompanied by a selective increase and decrease, respectively, in the sensitivity of cerebrocortical neurons in the same region to [beta]-adrenergic stimulation. These results suggest that changes in central adrenergic function might be related to the formation and/or expression of dependence on morphine.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/26883/1/0000449.pd