Contrast-Enhanced Magnetic Resonance Angiography - Development and optimization of techniques for paramagnetic and hyperpolarized contrast media

Contrast-enhanced magnetic resonance angiography (CE-MRA) is a diagnostic method for imaging of vascular structures based on nuclear magnetic resonance. Vascular enhancement is achieved by injection of a contrast medium (CM). Studies were performed using two different types of CM: conventional paramagnetic CM, and a new type of CM based on hyperpolarized (HP) nuclei. The effects of varying CM concentration with time during image acquisition were studied by means of computer simulations using two different models. It was shown that a rapid concentration variation during encoding of the central parts of k-space could result in signal loss and severe image artefacts. The results were confirmed qualitatively with phantom experiments. A post-processing method was developed to address problems with simultaneous enhancement of arteries and veins in CE-MRA of the lower extremities. The method was based on the difference in flow-induced phase in the two vessel types. Evaluation of the method was performed with flow phantom measurements and with CE-MRA in two volunteers using standard pulse sequences. The flow-induced phase in the vessels of interest was sufficient to distinguish arteries from veins in the superior-inferior direction. Using this method, the venous enhancement could be extinguished. The possibility of using HP nuclei as CM for CE-MRA was evaluated. Signal expressions for a flow of HP CM imaged with a gradient echo sequence were derived. These signal expressions were confirmed in phantom experiments using HP 129Xe dissolved in ethanol. Studies were also performed with a new CM based on HP 13C. The CM had very long relaxation times (T1/T2 = 38/1.3 s, in vivo). The long relaxation times were utilized in imaging with a fully balanced steady-state free precession pulse sequence (trueFISP), where the optimal flip angle was found to be 180º. CE-MRA with the 13C-based CM in rats resulted in images with high vascular SNR (~500). CE-MRA is a useful clinical tool for diagnosing vascular disease. With the development of new contrast media, based on hyperpolarized nuclei for example, there is a potential for further improvement in the signal levels that can be achieved, enabling a standard of imaging of vessels that is not possible today

Proto-basement in Svalbard

Candidates for possible Precambrian proto-basement throughout Svalbard are considered and evaluated. The paper provides a tectono-stratigraphic framework for consideration of new data. Proto-basement, in the sense of basement in Proterozoic time, implies the occurrence of a Precambrian tectonic event. Vendian rocks are widespread in Svalbard and, because there is no known Vendian major tectonic event, the search is narrowed to pre-Vendian rocks. The approach is primarily tectono-stratigraphic, to identify a significant break by unconformity, contrast in metamorphic facies and isotopic age determinations. The paper concludes that the following rock units are proto-basement: Isbjømhamna and (newly defined) Eimfjellet groups, Nordbukta Group, Magnethøgda Group, the Richarddalen Complex; the Atomfjella Complex, the Brennevinsfjorden Group and the granitoids related to the Kapp Hansteen Group and the Duvefjorden Complex. While considered unlikely to be proto-basement the following cannot be ruled out: the Mefonntoppane and Kistefjellet rocks and the Sigfredbogen unit, the blue-schist Vestgötabreen rocks, the Pinkie Formation and parts of the Kongsvegen Group. Terrane implications are consistent with the three terrane model of Harland & Wright (1979), modified by Harland et al. (1993); but the data presented here hardly constrain such a model. In so far as the conclusions here are valid the effect is to subtract from, rather than add to, the outcrops commonly mapped as likely proto-basement