Erythema nodosum and the risk of tuberculosis in a high incidence setting

Objective: This study estimates the erythema nodosum (EN) incidence in a tuberculosis (TB) endemic setting and evaluates the likelihood of a subsequent TB diagnosis among individuals with Mycobacterium tuberculosis infection (MTI) with or without EN. Design: We estimated EN incidence rates (IRs) in East Greenland in 2010–2011 and conducted a cohort study following all individuals who tested positive for MTI from 1 January 2010 until 31 December 2012. A personal identifier allowed individual follow-up in the mandatory TB register. MTI was defined by a positive interferon-gamma release assay. TB incidence rate ratios (IRRs) among participants with or without EN were estimated with the Cox proportional hazard model. Results: We identified 38 EN cases corresponding to an IR of 500/100,000 inhabitants/year. All cases were among individuals with MTI. The EN IR was 11.79 (95% CI 5.73–24.27) times higher for BCG-unvaccinated compared with BCG-vaccinated individuals. The TB IRR was 25 (95% CI 11–60) within 1 month of EN compared to individuals without EN. Conclusion: This study documents a high EN incidence in a TB endemic region. EN occurred only in individuals with MTI, and predominantly among BCG-unvaccinated individuals. EN was significantly associated with a TB diagnosis within 1 month of diagnosis

High prevalence of atrial fibrillation among Greenlanders with ischemic stroke – atrial fibrillation found in more than 30% of cases

Objectives. To estimate the prevalence of atrial fibrillation among Greenlanders with ischemic stroke. Study design. A cross-sectional study. Methods. Information on atrial fibrillation and vitamin K antagonistic treatment at admittance and at discharge was obtained for Greenlanders admitted to Queen Ingrid's Hospital in Nuuk with an ischemic stroke in 2011 or in 2012 with methods described in details elsewhere. Results. Of 139 patients (64 males and 75 females) Greenlanders with an ischemic stroke in 2011 (n=74) or 2012 (n=65), 5.0% (n=7) had known atrial fibrillation prior to stroke compared to 32.4% (n=45) after discharge (p<0.01). Conclusions. More than 30% of ischemic stroke patients in this study had atrial fibrillation and only 5% were diagnosed prior to the stroke, suggesting that unknown atrial fibrillation is a substantial risk factor of ischemic stroke among Greenlanders