Dynamics of bad-cavity enhanced interaction with cold Sr atoms for laser stabilization

Hybrid systems of cold atoms and optical cavities are promising systems for increasing the stability of laser oscillators used in quantum metrology and atomic clocks. In this paper we map out the atom-cavity dynamics in such a system and demonstrate limitations as well as robustness of the approach. We investigate the phase response of an ensemble of cold strontium-88 atoms inside an optical cavity for use as an error signal in laser frequency stabilization. With this system we realize a regime where the high atomic phase-shift limits the dynamical locking range. The limitation is caused by the cavity transfer function relating input field to output field. However, the cavity dynamics is shown to have only little influence on the prospects for laser stabilization making the system robust towards cavity fluctuations and ideal for the improvement of future narrow linewidth lasers.Comment: 10 pages, 7 figure

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Lasing on a narrow transition in a cold thermal strontium ensemble

Highly stable laser sources based on narrow atomic transitions provide a promising platform for direct generation of stable and accurate optical frequencies. Here we investigate a simple system operating in the high-temperature regime of cold atoms. The interaction between a thermal ensemble of $^{88}$Sr at mK temperatures and a medium-finesse cavity produces strong collective coupling and facilitates high atomic coherence which causes lasing on the dipole forbidden $^1$S$_0 \leftrightarrow ^3$P$_1$ transition. We experimentally and theoretically characterize the lasing threshold and evolution of such a system, and investigate decoherence effects in an unconfined ensemble. We model the system using a Tavis-Cummings model, and characterize velocity-dependent dynamics of the atoms as well as the dependency on the cavity-detuning.Comment: 9 pages, 7 figure

Oxygen restriction increases the infective potential of Listeria monocytogenes in vitro in Caco-2 cells and in vivo in guinea pigs

<p>Abstract</p> <p>Background</p> <p>Listeria monocytogenes has been implicated in several food borne outbreaks as well as sporadic cases of disease. Increased understanding of the biology of this organism is important in the prevention of food borne listeriosis.</p> <p>The infectivity of <it>Listeria monocytogenes </it>ScottA, cultivated with and without oxygen restriction, was compared in <it>vitro </it>and <it>in vivo</it>. Fluorescent protein labels were applied to allow certain identification of <it>Listeria </it>cells from untagged bacteria in <it>in vivo </it>samples, and to distinguish between cells grown under different conditions in mixed infection experiments.</p> <p>Results</p> <p>Infection of Caco-2 cells revealed that <it>Listeria </it>cultivated under oxygen-restricted conditions were approximately 100 fold more invasive than similar cultures grown without oxygen restriction. This was observed for exponentially growing bacteria, as well as for stationary-phase cultures.</p> <p>Oral dosage of guinea pigs with <it>Listeria </it>resulted in a significantly higher prevalence (p < 0.05) of these bacteria in jejunum, liver and spleen four and seven days after challenge, when the bacterial cultures had been grown under oxygen-restricted conditions prior to dosage. Additionally, a 10–100 fold higher concentration of <it>Listeria </it>in fecal samples was observed after dosage with oxygen-restricted bacteria. These differences were seen after challenge with single <it>Listeria </it>cultures, as well as with a mixture of two cultures grown with and without oxygen restriction.</p> <p>Conclusion</p> <p>Our results show for the first time that the environmental conditions to which <it>L. monocytogenes </it>is exposed prior to ingestion are decisive for its <it>in vivo </it>infective potential in the gastrointestinal tract after passage of the gastric barrier. This is highly relevant for safety assessment of this organism in food.</p