A Study on the Participation of Peasants in Rural Environmental Improvement From the Perspective of Sustainable Development

Peasants are producers and the direct stakeholders of rural environmental problems, and also the core subject of the comprehensive rural ecological improvement. However, in the current mode of rural environmental governance, the government takes the dominant role, with low participation of peasants. Based on the representative micro-survey data of China, and from the perspective of the psychosocial effects of the peasants’ self-identification, this research made use of instrumental variables and generalized structural equation mode (GSEM) to explore the reason behand this phenomenon. The research shows that, first, at present Chinese peasants have a low degree of self-identification, and self-identification has a remarkable and positive stimulating effect on the participation of peasants in rural ecological improvement; second, heterogeneity analysis shows that self-identification is a stronger incentive for peasant groups with female offspring and rural families with relatively higher incomes in the participation of rural environmental improvement, and is a less remarkable incentive for rural families with relatively low incomes; and third, the mediation model results indicate that social fairness and social capital are important mediating paths with which self-identification influences the participation of peasants in rural environmental improvement, and the exertion of the stimulating effect of self-identification on the participation in rural environmental improvement is inseparable from the coordination and integration of the perception effect of peasants as the behavioral subject in terms of social fairness, and is still more inseparable from the support of corresponding social capital. What we’ve discovered means that the enhancement of self-identification of peasants by strengthening the construction of public cultural services and cultural guidance in rural area is the crucial element to motivate the peasants to participate in rural environmental improvement so as to realize sustainable rural development

Research Progress in Techniques for Postharvest Preservation of Green Sweet Peppers

Green sweat peppers are rich in nutrients and diverse in shape and color. Apart from being eaten as a vegetable, it is widely used as seasoning and side dishes. Due to respiration and infection by harmful microorganisms, postharvest green peppers are prone to water loss, wilting and even rot. Appropriate preservation technology can maximize the preservation of nutrients and extend the storage period of green peppers. This paper introduces the techniques used for postharvest preservation of green sweet peppers: physical preservation methods such as refrigeration and packaging, biological preservatives such as microbial, plant and animal extracts, and chemical preservatives such as calcium agents and 1-methylcyclopropene (1-MCP), and compares the advantages and disadvantages of these preservation techniques. It elaborates the effect of chitosan or konjac glucomannan-based composite coatings on preserving the quality of green sweet peppers. Our intention is to provide a reference and guidance for the storage and preservation of postharvest green peppers

Erchen Decoction Ameliorates Lipid Metabolism by the Regulation of the Protein CAV-1 and the Receptors VLDLR, LDLR, ABCA1, and SRB1 in a High-Fat Diet Rat Model

Lipid metabolism disorder is a common metabolic disorder characterized by abnormal lipid levels in blood. Erchen decoction (ECD) is a traditional Chinese medicine prescription, which is used for the treatment of diseases caused by retention of phlegm dampness. It has been reported to ameliorate the disorder of lipid metabolism. The aim of the present study was to investigate the effects and underlying mechanisms of ECD in lipid metabolism disorder induced by a high-fat diet (HFD) in rats. ECD (4.35g/kg/d) and atorvastatin (10mg/kg/d, positive control) were orally administered to HFD-fed rats for four weeks. The parameters, food, water consumption, body weight, body length, liver, and visceral fat weight and the content of serum lipids and lipid transporters were assessed. The effects of ECD on the mRNA and protein expression levels of lipid transport factors were measured by real-time PCR and western blotting. The present study demonstrated that ECD improved the disorders of serum lipid and lipid transporters in HFD-fed rats, TG (0.70±0.08 mmol/L, p0.05). Concomitantly, ECD reversed the abnormal expressions of those lipid transport factors in the liver and visceral fat

Factor and Cluster Analysis for TCM Syndromes of Real-World Metabolic Syndrome at Different Age Stage

Background. Traditional Chinese medicine (TCM) has the characteristics of multitarget and overall regulation, which has certain advantages in preventing and treating of metabolic syndrome (MS). The aim of the present study was to evaluate the similarities and differences of TCM syndrome distribution in different age groups to promote the optimization of treatment strategies. Methods. This study was based on a real-world survey conducted in 3 hospitals in China. There are 1262 collected cases of MS meeting the inclusion criteria, which were divided into the young group, middle-aged group, and elderly group. Factor analysis (FA) was conducted for syndrome element extraction, and K-means cluster analysis was processed for syndrome type classification. Frequency analysis and Chi-square test were used to compare the syndrome characteristics of each group. Results. Common factors extracted were assigned to 18 syndrome elements including 11 nature syndrome elements and 7 location syndrome elements. Phlegm and dampness are the most frequent syndrome elements in general. Compared with the middle-aged group and elderly group, the young group has more obvious nature syndrome elements in heat and Qi deficiency, and location syndrome elements in the stomach. As for the middle-aged group, the frequency of location syndrome in kidney syndrome was higher than that in other groups. When it comes to the elderly group, it is shown that the symptoms of Yin deficiency and blood deficiency increase with age and the old patients may have more location syndrome elements in the lung and gallbladder. Conclusion. The TCM syndrome of MS is complex in that there may be the characteristics of deficiency and excess syndrome simultaneously. The main pathological factors of MS were phlegm and dampness. Besides, MS patients at different age periods may have their own syndrome distribution features. So, it is reasonable to adhere to the method of resolving phlegm and removing dampness and, at the same time, adopt the ways of clearing heat, promoting Qi, nourishing Yin, supplementing blood as well as regulating the liver, promoting the lung, transporting the spleen, nourishing the heart, and nourishing the kidney based on the syndrome feature of MS in different age stages

Verification of the Efficacy and Safety of Qi-Replenishing Chinese Medicine in Treating Prediabetes: A Meta-Analysis and Literature Review

Background. Qi-replenishing Chinese medicines (QCMs) are used for treating prediabetes in the traditional Chinese medicine (TCM) clinical practice. The aims of this meta-analysis were to (i) verify the efficacy and safety of QCMs in treating prediabetes and (ii) investigate the clinical outcomes between the trials complying with and not complying with the principle of “syndrome differentiation.” Methods. We included only randomized controlled clinical trials (RCTs) whose Jadad scores were not less than 4. The overall clinical outcomes, including the incidence rate of diabetes, normalization of blood glucose, changes in fasting blood glucose (FBG), 2 h postprandial blood glucose, HbA1c, and occurrence of adverse events, were evaluated. Subgroup analyses were performed. Results. A total of 11 RCTs that enrolled 2210 patients with prediabetes were included. We observed that overall treatment with QCMs significantly ameliorated the clinical outcomes of prediabetes without increasing incidence of adverse events. The results of subgroup analyses revealed that prescribing QCMs complying with syndrome differentiation ameliorated all the clinical indices, whereas prescribing not complying with syndrome differentiation could not achieve significant amelioration in FBG and HbA1c levels. Furthermore, the subgroup with syndrome differentiation reported more adverse events. Conclusions. The overall results suggested that QCMs are effective and safe in treating prediabetes. Results of subgroup analyses indicated that the groups with syndrome differentiation presented better efficacy but had a higher occurrence of adverse events. This study indicated the important role of the principle of syndrome differentiation in TCM and that the adverse events of QCMs cannot be ignored in TCM clinical practice

Long-Term immunopersistence and safety of the Escherichia coli-produced HPV-16/18 bivalent vaccine in Chinese adolescent girls

The study assessed long-term immunopersistence and safety of the Escherichia coli (E. coli)-produced HPV-16/18 bivalent vaccine. In total, 979 participants in the initial immunogenicity noninferiority study, including girls aged 9-14 years who were randomized in a 1:1 ratio to receive 2 doses at months 0 and 6 (n = 301) or 3 doses at months 0, 1 and 6 (n = 304); girls aged 15-17 years (n = 149) and women aged 18–26 years (n = 225) who received 3 doses of the vaccine, were invited to participate in follow-up to 30 months post vaccination (NCT03206255). Serum samples were collected at months 18 and 30, and anti-HPV-16/18 IgG antibodies were measured by enzyme-linked immunosorbent assay. Serious adverse events (SAEs) occurred from month 7 through month 30 were recorded. At month 30, in the per-protocol set, all participants remained seropositive, except for one girl in the 9-14 years (2 doses) group who seroconverted to negative for HPV-18. HPV-16 and HPV-18 antibody levels were higher in girls aged 9-17 years who received 3 doses (125.3 and 60.2 IU/ml) than in women aged 18-26 years who received 3 doses (72.6 and 28.3 IU/ml), and those in girls aged 9-14 years who received 2 doses (73.2 and 24.9 IU/ml) were comparable to those in women aged 18-26 years who received 3 doses. No SAEs were reported to be causally related to vaccination. The E. coli-produced bivalent HPV-16/18 vaccine is safe and induces persistent protective antibodies for up to 30 months after vaccination in girls aged 9-17 years receiving 2 or 3 doses

The Metabolomic Rationale for Treating Perimenopausal Syndrome as Kidney Deficiency

Background. Traditional Chinese medicine (TCM) typically attributes the etiopathogenesis of perimenopausal syndrome (PMS) to kidney deficiency in the TCM stratification system for diagnosis. However, the molecular basis of this classical attribution remains to be investigated. Aim of the Study. By unraveling the responses to TCM treatment for kidney deficiency, the metabolomic link between PMS and kidney deficiency can be evaluated for in-depth understanding of the mechanism of TCM treatment and development of better treatment protocols. Materials and Methods. With naturally aged rats as a model for PMS, the metabolomic response to TCM treatment for kidney deficiency was investigated by 1H NMR. Results. 1H NMR metabolomic evidence of plasma samples demonstrates that treatments with two classical TCM prescriptions for kidney deficiency, decoctions of Yougui and Zuogui, result in modulating the metabolic state of the disease model towards that of rats of younger age. Conclusion. The data support the notion that kidney deficiency is responsible, in part at least, for PMS, and the relevant prescriptions are helpful in dampening the changes in the body’s metabolic states to alleviate symptoms of the disorder

Naturally acquired HPV antibodies against subsequent homotypic infection: A large-scale prospective cohort study

宫颈癌是全球15-44岁女性中第二常见的癌症，其主要病因是高危型HPV的感染，尤其是HPV 16型和18型的感染，在我国与约84%的宫颈癌有关。早期研究显示因自然免疫获得抗体的女性再次感染同型HPV的风险降低较为有限（约35%），但在这些研究中多依据IgG抗体而非中和抗体作为自然免疫指标进行保护效果分析。我校研究人员利用国产双价HPV疫苗III期临床试验中未接种HPV疫苗且HPV DNA为阴性的3600余名18-45岁健康女性队列，分别采用中和抗体和IgG抗体作为获得自然免疫的指标，分析其在之后5.5年的随访期间再次感染同型HPV的风险。该研究首次在大样本长期随访队列中以中和抗体作为免疫指标评价HPV自然免疫效果，获得了客观准确的HPV自然免疫数据，丰富了HPV自然史研究，为HPV疫苗接种策略的制订提供了重要依据。我校博士生姚星妹、中国医学科学院肿瘤医院陈汶教授和北京大学人民医院赵超教授为该论文共同第一作者。我校吴婷教授、张军教授、夏宁邵教授和中国医学科学院肿瘤医院乔友林教授、赵方辉教授为该论文的共同通讯作者。Background: Although recent studies have suggested that naturally acquired Human papillomavirus (HPV) antibodies are partly protective against subsequent homotypic infection, the extent of protection remains indecisive. Here, we evaluate the protective effect of neutralizing and IgG antibodies simultaneously. Methods: In a cohort of 3634 women aged 18-45 years from the control arm of a phase III trial of the HPV-16/18 bivalent vaccine, participants were tested for neutralizing antibodies by pseudovirion-based neutralization assay (PBNA) and IgG antibodies by enzyme-linked immunosorbent assay (ELISA) at baseline. HPV-16/18 incident and persistent infections were identified using cervical specimens periodically collected during the 5.5 years of follow-up. The protective effects of HPV-16/18 neutralizing and IgG antibodies against homotypic infection were assessed using a Cox proportional hazard model. Findings: For the persistent infection (PI) endpoints of HPV-16/18 lasting for over 6/12 months, a prevalence of type-specific neutralizing antibodies was highly protective (6-month PI: hazard ratio (HR) = 0.16,95% confidence interval (CI): 0.04, 0.65; 12-month PI: HR = 0.23, 95% CI: 0.06, 0.94), whereas a prevalence of IgG antibodies was associated with minor and non-significant protection (6-month PI: HR = 0.66, 95% CI: 0.40, 1.09; 12-month PI: HR = 0.66, 95% CI: 0.36, 1.20). After increasing the cut-off value to the median IgG level, the risk of 6-month PI was significantly lower in seropositive vs seronegative women (HR = 0.38, 95% CI: 0.18, 0.83). Interpretation: Naturally acquired antibodies are associated with a substantially reduced risk of subsequent homotypic infection.We thank all the study participants and research staff of the HPV-003 Study Group for their contributions to the present study. In addition, we also thank Dr. Allan Hildesheim of the Division of Cancer Epidemiology and Genetics at the National Cancer Institute, National Institutes of Health for his helpful comments on this study.该研究获得国家自然科学基金、福建省卫生教育联合攻关计划项目、厦门市科技重大专项、中国医学科学院医学科学创新基金和厦门万泰沧海生物技术有限公司的支持。Funding: NSFC; The Fujian Province Health Education Joint Research Project; Xiamen Science and Technology Major Project; CIFMS; and Xiamen Innovax