Stability of highly cooled hypervelocity boundary layers

The influence of high levels of wall cooling on the stability of hypervelocity boundary layers is investigated. Such conditions are relevant to experiments in high-enthalpy impulse facilities, where the wall temperature is much smaller than the free-stream temperature, as well as to some real flight scenarios. Some effects of wall cooling are well known, for instance, the stabilization of the first mode and destabilization of the second mode. In this paper, several new instability phenomena are investigated that arise only for high Mach numbers and high levels of wall cooling. In particular, certain unstable modes can travel supersonically with respect to the free stream, which changes the nature of the dispersion curve and leads to instability over a much wider band of frequencies. The cause of this phenomenon, the range of parameters for which it occurs and its implications for boundary layer stability are examined. Additionally, growth rates are systematically reported for a wide range of conditions relevant to high-enthalpy impulse facilities, and the stability trends in terms of Mach number and wall temperature are mapped out. Thermal non-equilibrium is included in the analysis and its influence on the stability characteristics of flows in impulse facilities is assessed

Magnet Laboratory Research

Contains reports on three research projects

Communicative competence and psychological aspects when interacting with client in tourism

The article deals with the role of psychological preparation of specialists in service and tourism to building relationships with clients of travel agencies. Attention is paid to what is important in psychological preparation of the expert assigned to the speech skill, because the possession of speech skills influences the formation of the motives and interests of the client, speed, completeness and the strength of assimilation of advertising materials, economy, recall; accuracy, consistency and brightness of managerial playback of the advertised materia

Structure and Function of the Mycobacterial Type VII Secretion Systems

Bacteria have evolved intricate secretion machineries for the successful delivery of large molecules across their cell envelopes. Such specialized secretion systems allow a variety of bacteria to thrive in specific host environments. In mycobacteria, type VII secretion systems (T7SSs) are dedicated protein transport machineries that fulfill diverse and crucial roles, ranging from metabolite uptake to immune evasion and subversion to conjugation. Since the discovery of mycobacterial T7SSs about 15 y ago, genetic, structural, and functional studies have provided insight into the roles and functioning of these secretion machineries. Here, we focus on recent advances in the elucidation of the structure and mechanism of mycobacterial T7SSs in protein secretion. As many of these systems are essential for mycobacterial growth or virulence, they provide opportunities for the development of novel therapies to combat a number of relevant mycobacterial diseases

Injection into Supersonic Boundary Layers

A method for injection of gas into the boundary layer on a slender body in supersonic flow while minimizing perturbation to the mean flow is examined. Injection of gas is equivalent to a sudden increase in the displacement thickness of the boundary layer, which produces an oblique shock that propagates into the inviscid region of the flow. It is found that modification of the geometry of the body can compensate for the increased displacement thickness created by injection and minimize the production of oblique waves. However, the resulting near-wall injection layer is observed to be unstable and a turbulent boundary layer develops downstream of the injection region. The instability of the flow is examined experimentally using high-speed schlieren visualization and numerically using linear stability analysis of velocity profiles from a compressible Navier–Stokes computation. At the present postshock Mach number of about 3.8, both first- and second-mode instabilities are active, though computations predict that the first mode is primarily responsible for transition downstream of the injector

Psycho-pedagogical adaptation of foreign students to the educational process in high school

The article discloses the specifics of psycho-pedagogical adaptation of foreign students to the educational process in university. It is noted that the impact of the adaptation of foreign students defines the following set of factors: psycho-physiological, educational, social and living condition

Measuring Pancharatnam's relative phase for SO(3) evolutions using spin polarimetry

In polarimetry, a superposition of internal quantal states is exposed to a single Hamiltonian and information about the evolution of the quantal states is inferred from projection measurements on the final superposition. In this framework, we here extend the polarimetric test of Pancharatnam's relative phase for spin$-{1/2}$ proposed by Wagh and Rakhecha [Phys. Lett. A {\bf 197}, 112 (1995)] to spin $j\geq 1$ undergoing noncyclic SO(3) evolution. We demonstrate that the output intensity for higher spin values is a polynomial function of the corresponding spin$-{1/2}$ intensity. We further propose a general method to extract the noncyclic SO(3) phase and visibility by rigid translation of two $\pi /2$ spin flippers. Polarimetry on higher spin states may in practice be done with spin polarized atomic beams.Comment: New title, minor corrections, journal reference adde

Stapling of Peptides Potentiates the Antibiotic Treatment of Acinetobacter baumannii In Vivo

The rising incidence of multidrug resistance in Gram-negative bacteria underlines the urgency for novel treatment options. One promising new approach is the synergistic combination of antibiotics with antimicrobial peptides. However, the use of such peptides is not straightforward; they are often sensitive to proteolytic degradation, which greatly limits their clinical potential. One approach to increase stability is to apply a hydrocarbon staple to the antimicrobial peptide, thereby fixing them in an α-helical conformation, which renders them less exposed to proteolytic activity. In this work we applied several different hydrocarbon staples to two previously described peptides shown to act on the outer membrane, L6 and L8, and tested their activity in a zebrafish embryo infection model using a clinical isolate of Acinetobacter baumannii as a pathogen. We show that the introduction of such a hydrocarbon staple to the peptide L8 improves its in vivo potentiating activity on antibiotic treatment, without increasing its in vivo antimicrobial activity, toxicity or hemolytic activity