Antianginal and anti-ischemic efficacy of immediate-release nisoldipine in chronic stable angina pectoris

A double-blind, randomized, placebo-controlled, crossover study tested peak and trough efficacy of immediate-release nisoldipine (20 mg twice daily) added to existent β-adrenergic blocking therapy. Patients were randomized with a history of chronic stable angina, while receiving a stable regimen of a β-blocking agent, with exercise test-induced angina in association with 1 mm horizontal or downsloping ST-segment depression and exercise test reproducibility of ± 15%. Ambulatory electrocardiographic monitoring (48-hour) was performed at 3 of 5 centers (44 patients). Efficacy was achieved in 53 patients (26 taking immediate-release nisoldipine/placebo in sequence and 27 taking placebo/immediate-release nisoldipine in sequence). Total exercise time increased compared with placebo at peak, but only a trend was seen at trough. Time to 1 mm ST-segment depression at peak and trough and ambulatory electrocardiographic parameters were also improved. Adverse effects were mild. This trial confirms that immediate-release nisoldipine when added to existent β-blocker therapy is an active antianginal and anti-ischemic agent, but that the immediate-release formulation loses its antianginal effect at the end of its dosing interval (9 to 14 hours). This drug is therefore being examined in a new extended-release formulation (Coat-Core). © 1994

Exploitation de la spectrométrie de masse en microbiologie: Une révolution

Since a few years, mass spectrometry constitutes a new promising tool in microbiology. Allowing a fast and reliable identification of microorganisms, Matrix-Assisted Laser Desorption-Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF MS) competes with traditional identification techniques. More recently, direct identification of bacteria and yeasts directly from clinical samples was described. Next to identification and typing applications, MALDI-TOF MS and other recent mass spectrometric technologies such as SELDI-TOF MS and PCR-ESI-MS are interesting tools for genotyping and testing bacterial susceptibility. © 2012.SCOPUS: sh.jinfo:eu-repo/semantics/publishe