Metabolism of triphenylmethane and triphenylcarbinol

A study of the metabolism of triphenylmethane and triphenylcarbinol in the rabbit indicates that the major urinary metabolite of these two compounds is the corresponding glucuronide. When 1 gm of triphenylmethane is fed to rabbits, approximately 35% of the dose is excreted unchanged in the feces, 45-55% is excreted in the urine as a glucuronide, and a small amount is converted to 4-hydroxytriphenylmethane. Urinary excretion of triphenylcarbinol as the glucuronide accounts for approximately 43% of a 1-gm dose fed to rabbits. Thirty-three% of the triphenylcarbinol is excreted unchanged in the feces.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/32109/1/0000159.pd