Floored Show Card

Floored Show Card featuring alumni Christine Bisetto. Joint Exhibition with the University of Texas at Dallas. October 5 - November 7, 2001.https://digitalcommons.udallas.edu/floored/1001/thumbnail.jp

Christine Bisetto, Bruce Campbell Show Card

Show card featuring alumni Christine Bisetto and Bruce Campbell.https://digitalcommons.udallas.edu/alumni_02-03/1005/thumbnail.jp

Floored Hung Show Card

Floored Hung Show Card featuring alumni Christine Bisetto. Joint exhibition with the University of Dallas. Sept. 28 - Oct. 26, 2001.https://digitalcommons.udallas.edu/floored/1002/thumbnail.jp

Untitled (Bowers, Hamilton, Schwarz, Steinfeld) Show Card

Show card for exhibition Untitled. September 7 - October 3, 2001.https://digitalcommons.udallas.edu/untitled/1001/thumbnail.jp

Cyclin D1 Restrains Oncogene-Induced Autophagy by Regulating the AMPK-LKB1 Signaling Axis.

Autophagy activated after DNA damage or other stresses mitigates cellular damage by removing damaged proteins, lipids, and organelles. Activation of the master metabolic kinase AMPK enhances autophagy. Here we report that cyclin D1 restrains autophagy by modulating the activation of AMPK. In cell models of human breast cancer or in a cyclin D1-deficient model, we observed a cyclin D1-mediated reduction in AMPK activation. Mechanistic investigations showed that cyclin D1 inhibited mitochondrial function, promoted glycolysis, and reduced activation of AMPK (pT172), possibly through a mechanism that involves cyclin D1-Cdk4/Cdk6 phosphorylation of LKB1. Our findings suggest how AMPK activation by cyclin D1 may couple cell proliferation to energy homeostasis

Faculty Exhibition Show Card

Show card for Faculty Exhibition. June 8 - July 25, 2001.https://digitalcommons.udallas.edu/fac_exhibit_01/1000/thumbnail.jp

Lactate efflux from intervertebral disc cells is required for maintenance of spine health.

Maintenance of glycolytic metabolism is postulated to be required for health of the spinal column. In the hypoxic tissues of the intervertebral disc and glycolytic cells of vertebral bone, glucose is metabolized into pyruvate for ATP generation and reduced to lactate to sustain redox balance. The rise in intracellular H+ /lactate concentrations are balanced by plasma-membrane monocarboxylate transporters (MCTs). Using MCT4 null mice and human tissue samples, complimented with genetic and metabolic approaches, we determine that H+ /lactate efflux is critical for maintenance of disc and vertebral bone health. Mechanistically, MCT4 maintains glycolytic and TCA cycle flux and intracellular pH homeostasis in the nucleus pulposus compartment of the disc, where HIF-1α directly activates an intronic enhancer in SLC16A3. Ultimately, our results provide support for research into lactate as a diagnostic biomarker for chronic, painful disc degeneration