Slow Coarsening in a Class of Driven Systems

The coarsening process in a class of driven systems is studied. These systems have previously been shown to exhibit phase separation and slow coarsening in one dimension. We consider generalizations of this class of models to higher dimensions. In particular we study a system of three types of particles that diffuse under local conserving dynamics in two dimensions. Arguments and numerical studies are presented indicating that the coarsening process in any number of dimensions is logarithmically slow in time. A key feature of this behavior is that the interfaces separating the various growing domains are smooth (well approximated by a Fermi function). This implies that the coarsening mechanism in one dimension is readily extendible to higher dimensions.Comment: submitted to EPJB, 13 page

Implementation of geotechnical and vegetation modules in TELEMAC to simulate the dynamics of vegetated alluvial floodplains

Water Qualit

Glycosidase activities in sound and rotten grapes in relation to hydrolysis of grape monoterpenyl glycosides

β-D-glucopyranosidase, α-L-arabinofuranosidase and α-L-rhamnopyranosidase activities were studied in grapes, both during maturation and in sound and rotten mature fruits. Enzymic activities increased during maturation. At maturity, in sound grapes, β-D-glucopyranosidase and α-L-arabinofuranosidase activities were the highest ones. Berry infection by fungi results in a decrease in β-glucosidase activity, while the others increase. The effect of an enzymic extract from a culture of Botrytis cinerea towards synthetic terpenyl glycosides showed that hydrolysis was strong for β-terpenyl rutinosides and weak for β-terpenyl 6-0-α-L-arabinofuranosyl-β-D-glucopyranosides

Sensitivity of simulated flow fields and bathymetries in meandering channels to the choice of a morphodynamic model

Morphodynamic models are used by river practitioners and scientists to simulate geomorphic change in natural and artificial river channels. It has long been recognized that these models are sensitive to the choice of parameter values, and proper calibration is now common practice. This paper investigates the less recognized impact of the choice of the model itself. All morphodynamic models purport to simulate the same flow and sediment dynamics, often relying on the same governing equations. Yet in solving these equations, the models have different underlying assumptions, for example regarding spatial discretization, turbulence, sediment inflow, lateral friction, and bed load transport. These differences are not always considered by the average model user, who might expect similar predictions from calibrated models. Here, a series of numerical simulations in meandering channels was undertaken to test whether six morphodynamic codes (BASEMENT, CCHE-2D, NAYS, SSIIM-1, TELEMAC-2D and TELEMAC-3D) would yield significantly different equilibrium bathymetries if subjected to identical, initial flow conditions. We found that, despite producing moderately similar velocity patterns on a fixed-flat bed (regression coefficient r of 0.77 ± 0.20), the codes disagree substantially with respect to simulated bathymetries (r = 0.49 ± 0.31). We relate these discrepancies to differences in the codes' assumptions. Results were configuration specific, i.e. codes that perform well for a given channel configuration do not necessarily perform well with higher or lower sinuosity configurations. Finally, limited correlation is found between accuracy and code complexity; the inclusion of algorithms that explicitly account for the effects of local bed slope and channel curvature effects on transport magnitude and direction does not guarantee accuracy. The range of solutions obtained from the evaluated codes emphasises the need for carefully considering the choice of code. We recommend the creation of a central repository providing universal validation cases and documentation of recognized fluvial codes in commonly studied fluvial settings. This article is protected by copyright. All rights reserved

Towards precision medicine for hypertension: a review of genomic, epigenomic, and microbiomic effects on blood pressure in experimental rat models and humans

Compelling evidence for the inherited nature of essential hypertension has led to extensive research in rats and humans. Rats have served as the primary model for research on the genetics of hypertension resulting in identification of genomic regions that are causally associated with hypertension. In more recent times, genome-wide studies in humans have also begun to improve our understanding of the inheritance of polygenic forms of hypertension. Based on the chronological progression of research into the genetics of hypertension as the "structural backbone," this review catalogs and discusses the rat and human genetic elements mapped and implicated in blood pressure regulation. Furthermore, the knowledge gained from these genetic studies that provide evidence to suggest that much of the genetic influence on hypertension residing within noncoding elements of our DNA and operating through pervasive epistasis or gene-gene interactions is highlighted. Lastly, perspectives on current thinking that the more complex "triad" of the genome, epigenome, and the microbiome operating to influence the inheritance of hypertension, is documented. Overall, the collective knowledge gained from rats and humans is disappointing in the sense that major hypertension-causing genes as targets for clinical management of essential hypertension may not be a clinical reality. On the other hand, the realization that the polygenic nature of hypertension prevents any single locus from being a relevant clinical target for all humans directs future studies on the genetics of hypertension towards an individualized genomic approach

Suv4-20h Histone Methyltransferases Promote Neuroectodermal Differentiation by Silencing the Pluripotency-Associated Oct-25 Gene

Post-translational modifications (PTMs) of histones exert fundamental roles in regulating gene expression. During development, groups of PTMs are constrained by unknown mechanisms into combinatorial patterns, which facilitate transitions from uncommitted embryonic cells into differentiated somatic cell lineages. Repressive histone modifications such as H3K9me3 or H3K27me3 have been investigated in detail, but the role of H4K20me3 in development is currently unknown. Here we show that Xenopus laevis Suv4-20h1 and h2 histone methyltransferases (HMTases) are essential for induction and differentiation of the neuroectoderm. Morpholino-mediated knockdown of the two HMTases leads to a selective and specific downregulation of genes controlling neural induction, thereby effectively blocking differentiation of the neuroectoderm. Global transcriptome analysis supports the notion that these effects arise from the transcriptional deregulation of specific genes rather than widespread, pleiotropic effects. Interestingly, morphant embryos fail to repress the Oct4-related Xenopus gene Oct-25. We validate Oct-25 as a direct target of xSu4-20h enzyme mediated gene repression, showing by chromatin immunoprecipitaton that it is decorated with the H4K20me3 mark downstream of the promoter in normal, but not in double-morphant, embryos. Since knockdown of Oct-25 protein significantly rescues the neural differentiation defect in xSuv4-20h double-morphant embryos, we conclude that the epistatic relationship between Suv4-20h enzymes and Oct-25 controls the transit from pluripotent to differentiation-competent neural cells. Consistent with these results in Xenopus, murine Suv4-20h1/h2 double-knockout embryonic stem (DKO ES) cells exhibit increased Oct4 protein levels before and during EB formation, and reveal a compromised and biased capacity for in vitro differentiation, when compared to normal ES cells. Together, these results suggest a regulatory mechanism, conserved between amphibians and mammals, in which H4K20me3-dependent restriction of specific POU-V genes directs cell fate decisions, when embryonic cells exit the pluripotent state

Natural killer cells attenuate cytomegalovirus-induced hearing loss in mice

<div><p>Congenital cytomegalovirus (CMV) infection is the most common non-hereditary cause of sensorineural hearing loss (SNHL) yet the mechanisms of hearing loss remain obscure. Natural Killer (NK) cells play a critical role in regulating murine CMV infection via NK cell recognition of the Ly49H cell surface receptor of the viral-encoded m157 ligand expressed at the infected cell surface. This Ly49H NK receptor/m157 ligand interaction has been found to mediate host resistance to CMV in the spleen, and lung, but is much less effective in the liver, so it is not known if this interaction is important in the context of SNHL. Using a murine model for CMV-induced labyrinthitis, we have demonstrated that the Ly49H/m157 interaction mediates host resistance in the temporal bone. BALB/c mice, which lack functional Ly49H, inoculated with mCMV at post-natal day 3 developed profound hearing loss and significant outer hair cell loss by 28 days of life. In contrast, C57BL/6 mice, competent for the Ly49H/m157 interaction, had minimal hearing loss and attenuated outer hair cell loss with the same mCMV dose. Administration of Ly49H blocking antibody or inoculation with a mCMV viral strain deleted for the m157 gene rendered the previously resistant C57BL/6 mouse strain susceptible to hearing loss to a similar extent as the BALB/c mouse strain indicating a direct role of the Ly49H/m157 interaction in mCMV-dependent hearing loss. Additionally, NK cell recruitment to sites of infection was evident in the temporal bone of inoculated susceptible mouse strains. These results demonstrate participation of NK cells in protection from CMV-induced labyrinthitis and SNHL in mice.</p></div

Tau neutrino deep inelastic charged current interactions

The nu_mu -> nu_tau oscillation hypothesis will be tested through nu_tau production of tau in underground neutrino telescopes as well as long-baseline experiments. We provide the full QCD framework for the evaluation of tau neutrino deep inelastic charged current (CC) cross sections, including next-leading-order (NLO) corrections, charm production, tau threshold, and target mass effects in the collinear approximation. We investigate the violation of the Albright-Jarlskog relations for the structure functions F_4,5 which occur only in heavy lepton (tau) scattering. Integrated CC cross sections are evaluated naively over the full phase space and with the inclusion of DIS kinematic cuts. Uncertainties in our evaluation based on scale dependence, PDF errors and the interplay between kinematic and dynamical power corrections are discussed and/or quantified.Comment: 28 pages, 10 figure

The AMANDA Neutrino Telescope and the Indirect Search for Dark Matter

With an effective telescope area of order 10^4 m^2, a threshold of ~50 GeV and a pointing accuracy of 2.5 degrees, the AMANDA detector represents the first of a new generation of high energy neutrino telescopes, reaching a scale envisaged over 25 years ago. We describe its performance, focussing on the capability to detect halo dark matter particles via their annihilation into neutrinos.Comment: Latex2.09, 16 pages, uses epsf.sty to place 15 postscript figures. Talk presented at the 3rd International Symposium on Sources and Detection of Dark Matter in the Universe (DM98), Santa Monica, California, Feb. 199