1 research outputs found
Association between functional network connectivity, retina structure and microvasculature, and visual performance in patients after thalamic stroke: An exploratory multiâmodality study
Abstract Background and objective Neuroâophthalmologic symptoms and retinal changes have been increasingly observed following thalamic stroke, and there is mounting evidence indicating distinct alterations occurring in the visionârelated functional network. However, the intrinsic correlations between these changes are not yet fully understood. Our objective was to explore the altered patterns of functional network connectivity and retina parameters, and their correlations with visual performance in patients with thalamic stroke. Methods We utilized restingâstate functional MRI to obtain multiâmodular functional connectivity (FC), and optical coherence tomographyâangiography to measure various retina parameters, such as the retinal nerve fiber layer (RNFL), ganglion cellâinner plexiform layer (GCIPL), superficial vascular complex (SVC), and deep vascular complex. Visual acuity (VA) was used as a metric for visual performance. Results We included 46 patients with firstâever unilateral thalamic stroke (mean age 59.74 ± 10.02 years, 33 males). Significant associations were found between FC of attentionâtoâdefault mode and SVC, RNFL, and GCIPL, as well as between FC of attentionâtoâvisual and RNFL (p < .05). Both RNFL and GCIPL exhibited significant associations with FC of visualâtoâvisual (p < .05). Only GCIPL showed an association with VA (p = .038). Stratified analysis based on a disease duration of 6 months revealed distinct and significant linking patterns in multiâmodular FC and specific retina parameters, with varying correlations with VA in each subgroup. Conclusion These findings provide valuable insight into the neural basis of the associations between brain network dysfunction and impaired visual performance in patients with thalamic stroke. Our novel findings have the potential to inform future targeted and individualized therapies. However, further comprehensive studies are necessary to validate our results