Global systematic review and meta-analysis of health-related quality of life in Behcet’s patients

Background: Behcet’s disease (BD) is a chronic fatal illness with a relapsing remitting nature and significant organ-threatening morbidity and mortality. The aim of this research was to examine studies which were conducted on investigation of prevalence of quality of life among patients with Behcet’s disease. Methods: A total of 13 articles were extracted from four main databases including PubMed, EMBASE, Scopus, and Web of Science from the onset of 2000 to January 2021. All studies published in English with the purpose of examining quality of life (QOL) among patients with BD or investigating its main determinants were included. Results: Totally, 1137 BD patients participated in 13 studies. Based on random effect analysis, the total score of physical health-related QOL was 46.7 (95% CI=41.26 to 52.13) and the total score of mental health-related QOL was 49.01 (95% CI=43.83 to 54.18) representing a moderate level of QOL among BD patients. Furthermore, weighted effect size analyses showed a significant correlation between QOL and variables such as patients’ age, gender, disease duration and depression (pvalue: 0.00). Conclusion: As the symptoms of BD worsen over time, patients confront with more severe body pain, mobility restrictions, and difficulties in chewing, eating, speaking and swallowing which negatively affect social interactions of patients and reduce their QOL. Furthermore, depression was proved to act as a deteriorating factor for Health-Related Quality of Life (HRQOL) among BD patients. Thus, patients need to be psychologically supported by a specialized team and be informed during the course of treatment to gain useful information about the disease, treatment approaches and coping strategies

Global prevalence of suicide in cancer patients: a systematic review and meta-analysis

Aim: Given that patients with cancer may commit suicide due to physical and mental problems, the present study objectives were to identify particular risk factors of different subgroup of patients including type of cancer, gender, age, type and time of suicide, and geographical region to facilitate early care and psychosocial support. Methods: A comprehensive review of databases including Embase, Scopus, PubMed, and Web of Science was conducted for original articles published in English from January 2000 to March 2022. It is based on the PRISMA checklist. Results: After reviewing 69 articles selected from 15 countries, the total prevalence rate of suicide among 34,157,856 patients with cancer was estimated 67,169, at 0.013 (95% CI, 0.008–0.021). The highest suicide prevalence was related to gastrointestinal cancer, estimated at 0.204 (95% CI, 0.161–0.255). A gender-based meta-analysis showed that the prevalence of suicide/suicidal ideation was higher among men, estimated at 0.013 (95% CI, 0.008–0.023) compared with women, at 0.006 (95% CI, 0.002–0.017). Conclusion: Based on study results, suicide-prevention strategies should be aimed at patients younger than 40 years of age to effectively resolve their mental health disorders and promote their self-efficacy in successful management of the disease

Global prevalence of suicide in patients living with HIV/AIDS: a systematic review and meta-analysis

Background: In fact, people living with HIV are at a greater risk of mental health disorders. Based on lack of necessary information in this area the present systematic review and meta-analysis study was conducted to determine the magnitude of committed suicides among HIV/AIDS people as well as their associated factors in a global setting. Method: Firstly we registered the protocol of study in PROSPRO. Then the publications were searched in the 4 main databases from January 2000 to April 2022. After removing duplication and inappropriate studies we applied inclusion and exclusion criteria. Finally 60 studies were included for analysis. Comprehensive meta-analysis software were used for analyzing. Results: After reviewing 60 articles published from January 2000 to April 2021 in 24 countries, the total prevalence rate of suicide among 61,904 patients was estimated at 0.249 (95 % CI, 0.2–0.306). Findings indicated that the highest suicide prevalence was related to single patients estimated at 0.257 (95 % CI, 0.184–0.347). A gender-based meta-analysis depicted that the prevalence of suicide/ suicidal ideation was higher among females estimated at 0.22 (95 % CI, 0.15–0.29) compared with men at 0.17 (95 % CI, 0.11–0.23). Conclusion: Health planners and policymakers should develop suicide-prevention strategies aimed at female patients in younger age groups who live alone and are deprived of social support to effectively promote their self-efficacy in successful management of the disease. Integrating mental health services into anti-retroviral therapy for HIV/AIDS patients is also suggested in order to effectively design integrated programs for the management of individuals living with HIV/AIDS

Global depression in Breast Cancer patients: systematic review and meta-analysis

Background: Breast cancer is known as one of the most common diseases among women, the psychological consequences of which are common in women and affect various aspects of their lives, so this study aims to investigate the prevalence of depression among women with breast cancer globally. Method: The present meta-analysis was performed by searching for keywords related to breast cancer and depression in 4 main databases: PubMed, Embase, Web of Sciences and Scopus in the period of January 2000 to November 2021 and the results of the study using R and CMA software were analyzed. Results: A total of 71 studies were selected in English and the results of the analysis showed that the prevalence of depression in women with breast cancer is 30.2%, with Pakistan having the highest (83%) prevalence of depression and Taiwan having the lowest (8.3%). And in the WHO regions, EMRO region had the highest (49.7%) rate and SEARO region had the lowest (23%) prevalence of depression. Also, with increasing age, the prevalence of depression among women with breast cancer increases. Conclusion: Community and family support for women with breast cancer, holding psychology and psychotherapy courses, lifestyle modifications and training in this area can be effective in preventing the reduction of the prevalence of depression, and given the pivotal role of women in family affairs, this This can be in line with the work of health system policymakers

Study of Car Accident Injuries Admitted to Hospitals Before and After Adoption of New Traffic Law in Iran

Background: Driving fines are one of the tools to reduce driving violations, and consequently, injuries due to car accidents. In 2010, a new set of laws and fines were passed with the aim of deterring driving violations. Since the second half of March 2013, the new laws and fines were enforced throughout the country. To compare the number of accident victims referred to the hospitals affiliated to Mashhad University of Medical Sciences before and after the implementation of the new traffic offenses law. Materials and Methods: This was a descriptive-analytic study. The study population consisted of all accident victims referred to the emergency department of hospitals of Mashhad University of Medical Sciences from March 2014 to September 2017. Sampling method was total enumerative method. For data collection, a checklist was used. After obtaining the necessary permissions, the researcher completed the checklist by referring to the hospitals and the Deputy of Treatment of Mashhad University of Medical Sciences. The relevant data were extracted from the Hospital Information and MedCare Systems. In addition to comparing the average number of victims before and after the implementation of the new law, the average number of victims were compared in terms of the body part injury, the site of the accident before and after the implementation of the law. The obtained data were analyzed by using descriptive and analytical statistics including t test. Results: The average monthly number of casualties before the implementation of the new law was 3053 and after the implementation it increased to 3492 people. This difference was statistically significant (P≤0.05). Although this increase was observed in the average number of the victims in all four body parts groups, after the implementation of the law, only the difference between the average number of victims with multiple body injuries was statistically significant (P≤0.05). In addition, the average number of the accident location in all four groups of the accident locations increased after the implementation of the law. However, only the difference between the average number of the accidents occurred on suburban roads before and after the implementation was statistically significant (P≤0.05). Conclusion: On the whole, increasing driving fines does not seem to have a significant impact on reducing road traffic injuries. A more detailed investigation of this challenge is recommended to identify possible causes of the ineffectiveness of fines