A Co-Doped MnO2 catalyst for Li-CO2 batteries with low overpotential and ultrahigh cyclability.

Li-CO2 batteries can not only capture CO2 to solve the greenhouse effect but also serve as next-generation energy storage devices on the merits of economical, environmentally-friendly, and sustainable aspects. However, these batteries are suffering from two main drawbacks: high overpotential and poor cyclability, severely postponing the acceleration of their applications. Herein, a new Co-doped alpha-MnO2 nanowire catalyst is prepared for rechargeable Li-CO2 batteries, which exhibits a high capacity (8160 mA h g−1 at a current density of 100 mA g−1), a low overpotential (≈0.73 V), and an ultrahigh cyclability (over 500 cycles at a current density of 100 mA g−1), exceeding those of Li‐CO2 batteries reported so far. The reaction mechanisms are interpreted depending on in situ experimental observations in combination with density functional theory calculations. The outstanding electrochemical properties are mostly associated with a high conductivity, a large fraction of hierarchical channels, and a unique Co interstitial doping, which might be of benefit for the diffusion of CO2, the reversibility of Li2CO3 products, and the prohibition of side reactions between electrolyte and electrode. These results shed light on both CO2 fixation and new Li-CO2 batteries for energy storage

Chlorophenyl thiophene silicon phthalocyanine: Synthesis, two-photon bioimaging-guided lysosome target, and in vitro photodynamic efficacy

The development of efficient photosensitizers with high singlet oxygen quantum yield, strong fluorescent emission, excellent photostability, and specific organelle targeting is in great demand for the enhancement of PDT treatment efficiency. This study designed and synthesized a new two-photon photosensitizer chlorophenyl thiophene axially substituted silicon (IV) phthalocyanine (CBT-SiPc). CBT-SiPc showed specific targeting of lysosomes in living cells and good biocompatibility. Furthermore, high 1O2 generation efficiency and high PDT efficiency in MCF-7 breast cancers under irradiation were also demonstrated. The novel CBT-SiPc showed great potential in the application of lysosome-targeted and two-photon bioimaging-guided photodynamic cancer therapy

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Pediatric-inspired regimen for adolescent and adult patients with Philadelphia chromosome-negative acute lymphoblastic leukemia: a prospective study from China

Several international centers have used and reported pediatric-inspired regimens for adolescent and adult patients with Philadelphia chromosome-negative acute lymphoblastic leukemia (Ph- ALL). However, there is a lack of prospective data on the Chinese population. Herein, we performed a prospective study with a pediatric-inspired regimen (IH-2014 regimen) in treating adolescent and adult Ph- ALL patients in our center. From 2014 to 2021, a total of 415 patients aged between 14 and 65 years (median age, 27) were included in this study. After a median follow-up of 40.8 months, the 5-year overall survival, disease-free survival, and event-free survival rates were 53.8%, 51.1% and 45.0%, respectively. The regimen was generally well tolerated and safe, and the overall chemotherapy-related mortality was 3.6%. Age ≥ 40 years and persistent detectable minimal residual disease (MRD) post-induction were independent prognostic factors. Traditional risk factors for adult patients combined with MRD post-induction exhibit predictive significance for survival and relapse, which is helpful in the selection of subsequent treatment. Patients with high risk factors who can achieve deep MRD response after induction do not derive benefit from allogeneic hematopoietic stem cell transplantation

Obstacle avoidance of unmanned ship swarm based on virtual navigator and improved Hooke's law

ObjectiveAiming at the obstacle avoidance of unmanned ship swarm, this paper proposes an elastic formation control method based on a virtual navigator and improved Hooke's law.MethodsFirst, the external ellipse is obtained according to the length and width of the obstacle, and the virtual obstacle avoidance area, obstacle avoidance response area and free navigation area are then extended outward according to the aspect ratio in order to simplify obstacle avoidance on the surface of the water. Second, based on the virtual navigator and improved Hooke's law, the constraints on relative distance and speed between each members of the formation as well as those between each members of the formation and the virtual navigator are given, and the formation configuration of the multiple unmanned ships is set in the form of coordinates so as to construct an elastic formation model. Further, based on the obstacle annular repulsive field, the obstacle avoidance of a single unmanned ship is realized. The obstacle avoidance of the multiple unmanned ships can then be realized under the organization of the elastic formation. Moreover, the sailing process of unmanned ship is optimized to eliminate the phenomena of "wandering" and "shaking" in the process of formation and obstacle avoidance, and increase the smoothness of the movement of the unmanned ship. Finally, four unmanned ships are used to form a formation, and a simulation experiment based on Matlab is carried out.ResultThe results show that all obstacles are successfully bypassed, verifying the effectiveness and feasibility of the proposed method. ConclusionsThis method can achieve the avoidance of surface obstacles for unmanned ship swarms, giving them a certain ability to pass through complex environments, thereby providing references for the application and research of unmanned ship swarm obstacle avoidance