Trisodium bis­{1-[iminio­(morpholino)meth­yl]guanidinium} bis­[hexa­hydrogen­hexa­molybdoaluminate(III)] chloride icosa­hydrate

In the title compound, Na3(C6H15N5O)2[Al(OH)6Mo6O18]2Cl·20H2O, the [Al(OH)6Mo6O18]3− polyoxo­anion has a B-type Anderson structure exhibiting approximate D 3d symmetry. There are two types of sodium cations: the Na+ cations of type I have a distorted octa­hedral coordination geometry formed by six O atoms and are statistically distributed over two positions with equal occupancies, while the coordination polyhedra of the two Na+ cations of type II share one Cl anion located on an inversion center. The latter fragment, containing a Cl anion and two sodium cations, links two polyoxoanions into centrosymmetric blocks. The diprotonated 1-[imino­(morpholino)meth­yl]guanidinium cations and uncordinated water mol­ecules contribute to extensive N—H⋯O and O—H⋯O hydrogen bonding, resulting in the formation a three-dimensional supra­molecular structure

Diagnosis and prognostic value of circDLGAP4 in acute ischemic stroke and its correlation with outcomes

Rationale and aimsCircular RNAs are a subclass of noncoding RNAs in mammalian cells and highly expressed in the central nervous system. Although their physiological functions are not yet completely defined, they are thought to promise as stroke biomarkers because of their stability in peripheral blood.Sample Size Estimate: 222 participants.Methods and designThe plasma of patients with acute ischemic stroke (AIS) (n = 111) and non-stroke controls (n = 111) from November 2017 to February 2019 were enrolled in our research. The expression of circDLGAP4 in plasma was evaluated using real-time PCR.Study outcomesIn patients with AIS, circDLGAP4 was significantly decreased in comparison with non-stroke controls. The CircDLGAP4 level had a significant AUC of 0.7896 with 91.72% sensitivity and 64.83% specificity in diagnosing AIS. Furthermore, the circDLGAP4 level was related to smoking history and previous transient ischemic attack/stroke/myocardial infarction in all samples. The change rate in circDLGAP4 within the first 7 days showed an AUC curve of 0.960 in predicting an stroke outcome.ConclusioncircDLGAP4 could serve as biomarker for AIS diagnosis and prediction of stroke outcomes

Non-uniform Black Strings with Schwarzschild-(Anti-)de Sitter Foliation

We present some exact non-uniform black string solutions of 5-dimensional pure Einstein gravity as well as Einstein-Maxwell-dilaton theory at arbitrary dilaton coupling. The solutions share the common property that their 4-dimensional slices are Schwarzchild-(anti-)de Sitter spacetimes. The pure gravity solution is also generalized to spacetimes of dimensions higher than 5 to get non-uniform black branes.Comment: LaTeX 14 pages, 3 eps figures. V2: version appeared in CQ

The study of Seyfert 2 galaxies with and without infrared broad lines

From the literature, we construct from literature a sample of 25 Seyfert 2 galaxies (S2s) with a broad line region detected in near infrared spectroscopy and 29 with NIR BLR which was detected. We find no significant difference between the nuclei luminosity (extinction-corrected [OIII]~5007) and infrared color $\rm{f_{60}/f_{25}}$ between the two populations, suggesting that the non-detections of NIR BLR could not be due to low AGN luminosity or contamination from the host galaxy. As expected, we find significantly lower X-ray obscurations in Seyfert 2s with NIR BLR detection, supporting the unification scheme. However, such a scheme was challenged by the detection of NIR BLR in heavily X-ray obscured sources, especially in six of them with Compton-thick X-ray obscuration. The discrepancy could be solved by the clumpy torus model and we propose a toy model demonstrating that IR-thin X-ray-thick S2s could be viewed at intermediate inclinations, and compared with those IR-thick X-ray-thick S2s. We note that two of the IR-thin X-ray-thick S2s (NGC 1386 and NGC 7674) experienced X-ray transitions, i.e. from Compton-thin to Compton-thick appearance or vice versa based on previous X-ray observations, suggesting that X-ray transitions could be common in this special class of objects

Clinical observation of phacoemulsification and IOL combined with goniosynechialysis for age-related cataract merging with PACG

AIM: To investigate the curative effect of phacoemulsification and intraocular lens(IOL)implantation combined with goniosynechialysis in the treatment of age-related cataract merging with primary angle-closure glaucoma(PACG).METHODS: Totally 80 patients with age-related cataract merging with PACG were in our hospital from January 2014 to January 2016. The preoperative average intraocular pressure(IOP)was 33.22±3.17mmHg; the average depth of anterior chamber was 2.07±0.15mm; the dynamic situation of primary angle closure ≤1/2 cycle by gonioscope. They were randomly divided into Group A and B for doing a study. All the two groups were treated with phacoemulsification and intraocular lens implantation. And the Group A was with goniosynechialysis. The following up period was 2mo, and we observed the IOP, chamber depth and the anterior chamber angle.RESULTS: The change of chamber depth and intraocular pressure about the two groups: the average intraocular pressure of the Group A was 15.11±3.67mmHg,the chamber depth was 3.11±0.08mm; those of the Group B were 17.24±1.67mmHg, 2.76±0.15mm respectively; the differences had statistical significance(PPCONCLUSION: The phacoemulsification and intraocular lens implantation combined with goniosynechialysis in the treatment of age-related cataract merging with primary angle-dosure glaucoma is safe and reliable. It's simple to operate, and do not increase the risk of surgery

Yersinia pseudotuberculosis Exploits CD209 Receptors for Promoting Host Dissemination and Infection

Yersinia pseudotuberculosis is a Gram-negative enteropathogen and causes gastrointestinal infections. It disseminates from gut to mesenteric lymph nodes (MLNs), spleen, and liver of infected humans and animals. Although the molecular mechanisms for dissemination and infection are unclear, many Gram-negative enteropathogens presumably invade the small intestine via Peyer's patches to initiate dissemination. In this study, we demonstrate that Y. pseudotuberculosis utilizes its lipopolysaccharide (LPS) core to interact with CD209 receptors, leading to invasion of human dendritic cells (DCs) and murine macrophages. These Y. pseudotuberculosis CD209 interactions result in bacterial dissemination to MLNs, spleens, and livers of both wild-type and Peyer's patch-deficient mice. The blocking of the Y. pseudotuberculosis CD209 interactions by expression of 0-antigen and with oligosaccharides reduces infectivity. Based on the well-documented studies in which HIV-CD209 interaction leads to viral dissemination, we therefore propose an infection route for Y. pseudotuberculosis where this pathogen, after penetrating the intestinal mucosal membrane, hijacks the Y. pseudotuberculosis CD209 interaction antigen-presenting cells to reach their target destinations, MLNs, spleens, and livers.Peer reviewe