Meta-analysis of clinical randomized controlled trials comparing ReZOOM with ReSTOR multifocal intraocular lenses in cataract surgery

AIM: To systematic review the effectiveness of refractive multifocal intraocular lens(MIOL)ReZOOM <i>vs</i> diffractive MIOL ReSTOR in the treatment of cataract.<p>METHODS: Randomized controlled trials comparing refractive MIOL ReZOOM with diffractive MIOL ReSTOR were identified by searching CENTRAL, MEDLINE, EMbase, WANFANG MED ONLINE, CMJD, SinoMed, and CNKI. Related journals also were hand-searched. Methodological quality of randomized controlled trials(RCTs)was evaluated by simple evaluate method that recommended by the Cochrane Collaboration. Data extracted by two reviewers with designed extraction form. RevMan software(release 5.2)was used for data management and analysis.<p>RESULTS:A total of 7 trials(846 eyes)were included for systematic review. Subgroup analyses were used according to different model comparison of ReSTOR MIOL. The results showed a significant difference in the mean of the best distance corrected intermediate visual acuity(BDCIVA)in the ReZOOM MIOL group with WMD= -0.11, 95% <i>CI</i>(-0.16, -0.06)(<i>P</i><0.0001). It showed a significantly difference in the mean of the uncorrected near visual acuity(UCNVA), complete spectacle independent rate, halo rate and glare rate in the ReSTOR MIOL group with WMD= 0.09, 95% <i>CI</i>(0.05, 0.14)(<i>P</i><0.00001), WMD= 2.62, 95%<i>CI</i>(1.76, 3.91)(<i>P</i><0.00001), WMD=1.35, 95% <i>CI</i>(1.15, 1.60)(<i>P</i>=0.0004)and WMD= 1.29, 95% <i>CI</i>(1.09, 1.53)(<i>P</i>=0.003). There was no significant difference between the two groups in the mean of the uncorrected distance visual acuity(UCDVA), the uncorrected intermediate visual acuity(UCIVA), the best corrected distance visual acuity(BCDVA)and the best distance corrected near visual acuity(BDCNVA)with WMD -0.03, 95% <i>CI</i>(-0.06, 0.01)(<i>P</i>=0.15), WMD= -0.04, 95% <i>CI</i>(-0.09, 0.01)(<i>P</i>=0.10), WMD= -0.01, 95%<i>CI</i>(-0.04, 0.02)(<i>P</i>=0.55)and WMD= 0.06, 95% <i>CI</i>(-0.06, 0.17)(<i>P</i>=0.32). <p>CONCLUSION: Patients implanted with ReZOOM MIOL can provide better BDCIVA; patients implanted with ReSTOR MIOL show better UCNVA, are less likely to appear light halo, glare and other visual adverse reactions; correction in spectacles cases, patients implanted with ReZOOM or ReSTOR MIOL have considerable performances in the far and near visual acuity

Effectiveness of Multiple Daily Injections or Continuous Subcutaneous Insulin Infusion for Children with Type 1 Diabetes Mellitus in Clinical Practice

Aims. To determine whether multiple daily injections (MDIs) or continuous subcutaneous insulin infusion (CSII) contributes to better glucose control in children with different type 1 diabetes duration. Methods. Subjects were grouped according to early (≤1 year after disease onset; 1A) or late (1–3 years after onset; 2A) MDIs/CSII treatment initiation. Corresponding control groups (1B, 2B) received insulin injections twice daily. Results. HbA1c levels were consistently lower in group 1A than in group 1B (6 months (T2): 7.37% versus 8.21%; 12 months (T3): 7.61% versus 8.41%; 24/36 months (T4/T5): 7.61% versus 8.72%; all P<0.05), but were lower in group 2A than in group 2B only at T2 (8.36% versus 9.19%; P=0.04). Levels were lower in group 1A than in group 2A when disease duration was matched (7.61% versus 8.49%; P<0.05). Logistic regression revealed no correlation between HbA1c level and MDIs/CSII therapy. HbA1c levels were only negatively related to insulin dosage. Conclusions. Blood glucose control was better in patients receiving MDIs/CSII than in those receiving conventional treatment. Early MDIs/CSII initiation resulted in prolonged maintenance of low HbA1c levels compared with late initiation. MDIs/CSII therapy should be combined with comprehensive management

Study of elemental mercury re-emission through a lab-scale simulated scrubber

a b s t r a c t This paper describes a lab-scale simulated scrubber that was designed and built in the laboratory at Western Kentucky University&apos;s Institute for Combustion Science and Environmental Technology. A series of tests on slurries of CaO, CaSO 3 , CaSO 4 /CaSO 3 and Na 2 SO 3 were carried out to simulate recirculating slurries in different oxidation modes. Elemental mercury (Hg 0 ) re-emission was replicated through the simulated scrubber. The relationship between the oxidation-reduction potential (ORP) of the slurries and the Hg 0 re-emissions was evaluated. Elemental mercury re-emission occurred when Hg 2+ that was absorbed in the simulated scrubber was converted to Hg 0 ; then, Hg 0 was emitted from the slurry together with the carrier gas. The effects of both the reagents and the operational conditions (including the temperature, pH, and oxygen concentrations in the carrier gas) on the Hg 0 re-emission rates in the simulated scrubber were investigated. The results indicated that as the operational temperature of the scrubber and the pH value of the slurry increased, the Hg 0 concentrations that were emitted from the simulated scrubber increased. The Hg 0 re-emission rates decreased as the O 2 concentration in the carrier gas increased. In addition, the effects of additives to suppress Hg 0 re-emission were evaluated in this paper. Sodium tetrasulfide, TMT 15, NaHS and HI were added to the slurry, while Hg 2+ , which was absorbed in the slurry, was retained in the slurry as mercury precipitates. Therefore, there was a significant capacity for the additives to suppress Hg 0 re-emission

Modified Sequential Therapy Regimen versus Conventional Triple Therapy for Helicobacter Pylori Eradication in Duodenal Ulcer Patients in China: A Multicenter Clinical Comparative Study

Objective. Antimicrobial resistance has decreased eradication rates for Helicobacter pylori infection worldwide. To observe the effect of eradicating Helicobacter pylori (H. pylori) and the treatment of duodenal ulcer by 2 kinds of modified sequential therapy through comparing with that of 10-day standard triple therapy. Methods. A total of 210 patients who were confirmed in duodenal ulcer active or heal period by gastroscopy and H. pylori positive confirmed by rapid urease test, serum anti-H. pylori antibody (ELASE), or histological examination enrolled in the study. All the patients were randomly divided into three groups: group A (70 cases) and group B (70 cases) were provided 10-day modified sequential therapy; group C (70 cases) was provided 10-day standard triple therapy. Patients of group A received 20 mg of Esomeprazole, 500 mg of Clarithromycin for the first 5 days, followed by 20 mg of Esomeprazole, 500 mg of Clarithromycin, and 1000 mg of Amoxicillin for the remaining 5 days. Group B received 20 mg of Esomeprazole, 1000 mg of Amoxicillin for the first 5 days, followed by 20 mg of Esomeprazole, 500 mg of Clarithromycin, and 1000 mg of Amoxicillin for the remaining 5 days. Group C received 20 mg of Esomeprazole, 500 mg of Clarithromycin, and 1000 mg of Amoxicillin for standard 10-day therapy. All drugs were given twice daily. H. pylori eradication rate was checked four to eight weeks after taking the medicine by using a 13C urea breath test. In the first, second, third, seventh, twenty-first, thirty-fifth days respectively, the symptoms of patients such as epigastric gnawing, burning pain, and acidity were evaluated simultaneously. Results. Overall, 210 patients accomplished all therapy schemes, 9 case patients were excluded. The examination result indicated that the H. pylori eradication rate of each group was as follows: group A 92.5% (62/67), group B 86.8% (59/68), and group C 78.8% (52/66). The H. pylori eradication rate of group A was slightly higher than group B (P < 0.05) and both of them were obviously higher than group C (P < 0.05). Modified sequential therapy was significantly more effective in patients with clarithromycin-resistant strains (80%/67% versus 31%; P = 0.02). Symptoms improvement: all the three groups could improve the symptoms such as epigastric gnawing, burning pain, and acidity since the first day. There was no significant difference in total score descending of symptoms between each group (P > 0.05). Conclusions. All the three therapy schemes could alleviate symptoms of duodenal ulcer patients in China efficiently. But as far as eradicating H. pylori is concerned, the modified sequential therapy was better than standard triple therapy, especially the therapy scheme used in group A

Relationship of Glucagon-like Peptide 1 and Peptide YY with Catch-up Growth in Children Born Small for Gestational Age

INTRODUCTION: Children born small for gestational age (SGA) are at a greater risk of developing insulin resistance, type 2 diabetes, and cardiovascular disease in adulthood. Gastrointestinal peptides, some secreted by intestinal L cells, regulate glucose and lipid metabolism and act on the hypothalamus to regulate energy homeostasis. The aim of this study was to explore whether gastrointestinal peptides are involved in metabolic disorders in SGA, which remains unclear. METHODS: The secretion of glucagon-like peptide 1 (GLP-1) and peptide YY (PYY) were investigated in prepubertal children born SGA, the differences between catch-up growth and persistent short stature were compared, and correlation with glucose and lipid metabolism was analyzed. GLP-1, PYY, insulin-like growth factor 1, glucose, insulin, and lipid concentrations were analyzed in prepubertal children aged 4-10 years, stratified into three groups: short-SGA (SGA-s), catch-up growth SGA, and normal growth appropriate for gestational age (AGA). RESULTS: Fasting GLP-1 and PYY concentrations were significantly lower in the SGA group than in the AGA group (p<0.05), and the GLP-1 level in infants born SGA with catch-up growth was lower than that in the SGA-s group (p<0.05). In the SGA population, GLP-1 showed a weak negative correlation with catch-up growth (r=-0.326) and positive correlation with fasting insulin (r=0.331). DISCUSSION AND CONCLUSION: Lower GLP-1 concentrations may be associated with abnormal glucose metabolism in prepubertal children born SGA with catch-up growth. This is indirect evidence that impaired intestinal L cell function may be involved in the development of metabolic complications in SGA children

Kvantna teorija difrakcije neutrona na mnogo pukotina

We study neutron multiple-slit diffraction with a quantum mechanical approach. For the double-slit diffraction, we obtain the following results: (1) when the ratio (d + a)/a = n (n = 1, 2, 3, · · ·), orders n, 2n, 3n, · · · are missing in the diffraction pattern. (2) When the ratio of (d + a)/a /= n (n = 1, 2, 3, · · ·), there isn’t any missing order in the diffraction pattern. For diffraction on N (N ≥ 3) slits, we obtain the following results: (1) There are N − 2 secondary maxima and N − 1 minima between the two principle maxima. (2) As the slit number N increases, the diffraction intensity increases and the peak widths become narrower. (3) As the slit width increases, the diffraction intensity increases and the pattern width becomes narrower. (4) When the two-slit distance d increases, the number of principle maxima increases and the pattern becomes narrower. (5) We find a new quantum effect that the slit thickness c has a large effect to the multiple-slit diffraction pattern. We think all predictions in this work can be tested by neutron multiple-slit diffraction experiments.Proučavamo difrakciju neutrona na mnogo pukotina kvantno-mehaničkim pristupom. Za dvije pukotine postigli smo ove ishode računa: (1) Kada je omjer (d + a)/a = n (n = 1, 2, 3, · · ·), izostaju redovi n, 2n, 3n, · · · u difrakcijskoj slici. (2) Kada je (d + a)/a /= n (n = 1, 2, 3, · · ·), svi se redovi javljaju u difrakcijskoj slici. Za difrakciju na N (N ≥ 3) pukotina dobili smo ove ishode: (1) Između dva osnovna maksimuma javljaju se N − 2 sekundarna maksimuma i N − 1 minimuma. (2) Kako se broj pukotina povećava, povećava se intenzitet difrakcijske slike i širine vrhova se smanje. (3) Kad se širina pukotina poveća, pojača se intenzitet difrakcije a vrhovi se suze. (4) Ako se poveća razmak pukotina d, poveća se broj glavnih maksimuma i oni se suze. (5) Nalazimo nov kvantni efekt da duljina pukotina c ima velik utjecaj na difrakcijsku sliku u slučaju mnogo pukotina. Vjerujemo da će se ishodi ovog rada provjeriti mjerenjem neutronske difrakcije na rešetci s mnogo pukotina

A conserved odorant receptor identified from antennal transcriptome of Megoura crassicauda that specifically responds to cis-jasmone

peer reviewedHerbivore-induced plant volatiles (HIPVs) play a key role in the interactions between plants and herbivorous insects, as HIPVs can promote or deter herbivorous insects’ behavior. While aphids are common and serious phloem-feeding pests in farmland ecosystems, little is known about how aphids use their sensitive olfactory system to detect HIPVs. In this study, the antennal transcriptomes of the aphid species Megoura crassicauda were sequenced, and expression level analyses of M. crassicauda odorant receptors (ORs) were carried out. To investigate the chemoreception mechanisms that M. crassicauda uses to detect HIPVs, we performed in vitro functional studies of the ORs using 11 HIPVs reported to be released by aphid-infested plants. In total, 54 candidate chemosensory genes were identified, among which 20 genes were ORs. McraOR20 and McraOR43 were selected for further functional characterization because their homologs in aphids were quite conserved and their expression levels in antennae of M. crassicauda were relatively high. The results showed that McraOR20 specifically detected cis-jasmone, as did its ortholog ApisOR20 from the pea aphid Acyrthosiphon pisum, while McraOR43 did not respond to any of the HIPV chemicals that were tested. This study characterized the ability of the homologous OR20 receptors in the two aphid species to detect HIPV cis-jasmone, and provides a candidate olfactory target for mediating aphid behaviors

The Large Sky Area Multi-object Fiber Spectroscopic Telescope (LAMOST) Quasar Survey: Quasar Properties from Data Release Six to Nine

We report the fourth installment in the series of the Large Sky Area Multi-Object Fiber Spectroscopic Telescope (LAMOST) Quasar Survey, which includes quasars observed between September, 2017 and June, 2021. There are in total 13,066 quasars reliably identified, of which 6,685 are newly discovered that are not reported in the SDSS DR14 quasar catalog or Million Quasars catalog. Because LAMOST does not provide accurate absolute flux calibration, we re-calibrate the spectra with the SDSS/Pan-STARRS1 multi-band photometric data. The emission line properties of H$\alpha$, H$\beta$, Mg\,{\sc ii} and C\,{\sc iv}, and the continuum luminosities are measured by fitting the re-calibrated spectra. We also estimate the single-epoch virial black hole masses ($\rm M_{BH}$) using the derived emission line and continuum parameters. This is the first time that the emission line and continuum fluxes were estimated based on LAMOST re-calibrated quasar spectra. The catalog and spectra for these quasars are available online. After the nine-year LAMOST quasar survey, there are in total 56,175 identified quasars, of which 24,127 are newly discovered. The LAMOST quasar survey not only discovers a great number of new quasars, but also provides a database for investigating the spectral variability of the quasars observed by both LAMOST and SDSS, and finding rare quasars including changing-look quasars and broad absorption line quasars.Comment: arXiv admin note: text overlap with arXiv:1811.01570, Accepted by ApJ