12,154 research outputs found
International investment positions and exchange rate dynamics : a dynamic panel analysis
In this paper we revisit medium- to long-run exchange rate determination, focusing on the role of international investment positions. To do so, we develop a new econometric framework accounting for conditional long-run homogeneity in heterogeneous dynamic panel data models. In particular, in our model the long-run relationship between effective exchange rates and domestic as well as weighted foreign prices is a homogeneous function of a countryâs international investment position. We find rather strong support for purchasing power parity in environments of limited negative net foreign asset to GDP positions, but not outside such environments. We thus argue that the purchasing power parity hypothesis holds conditionally, but not unconditionally, and that international investment positions are an essential component to characterizing this conditionality. Finally, we adduce evidence that whether deterioration of a countryâs net foreign asset to GDP position leads to a depreciation of that countryâs effective exchange rate depends on its rate of inflation relative to the rate of inflation abroad as well as its exposure to global shocks. JEL Classification: F31, F37, C2
Maternal haemodynamic function differs in preâeclampsia when it is associated with a smallâforâgestationalâage newborn: a prospective cohort study
Objective
To describe maternal haemodynamic differences in gestational hypertension with smallâforâgestationalâage babies (HDP + SGA), gestational hypertension with appropriateâforâgestationalâage babies (HDPâonly) and control pregnancies.
Design
Prospective cohort study.
Setting
Tertiary Hospital, UK.
Population
Women with gestational hypertension and healthy pregnant women.
Methods
Maternal haemodynamic indices were measured using a nonâinvasive Ultrasound Cardiac Output Monitor (USCOMâ1AÂź) and corrected for gestational age and maternal characteristics using deviceâspecific reference ranges.
Main outcome measures
Maternal cardiac output, stroke volume, systemic vascular resistance.
Results
We included 114 HDP + SGA, 202 HDPâonly and 401 control pregnancies at 26â41 weeks of gestation. There was no significant difference in the mean arterial blood pressure (110 versus 107 mmHg, P = 0.445) between the two HDP groups at presentation. Pregnancies complicated by HDP + SGA had significantly lower median heart rate (76 versus 85 bpm versus 83 bpm), lower cardiac output (0.85 versus 0.98 versus 0.97 MoM) and higher systemic vascular resistance (1.4 versus 1.0 versus 1.2 MoM) compared with control and HDPâonly pregnancies, respectively (all P < 0.05).
Conclusion
Women with HDP + SGA present with more severe haemodynamic dysfunction than HDPâonly. Even HDPâonly pregnancies exhibit impaired haemodynamic indices compared with normal pregnancies, supporting a role of the maternal cardiovascular system in gestational hypertension irrespective of fetal size. Central haemodynamic changes may play a role in the pathogenesis of preâeclampsia and should be considered alongside placental aetiology
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