Coexistence of hyperthyroidism and thyroid cancer

Objective: Thyroid cancer can be associated with thyrotoxicosis caused by Graves' disease, toxic multinodular goiter, or toxic nodular goiter. The aim of this study was considered to be endemic in our region have received the diagnosis of hyperthyroidism, thyroid cancer is detected thyroidectomy performed and patients were retrospectively evaluate. Methods: We retrospectively studied 69 patients assessed for hyperthyroidism between 2006 and 2012. Clinical hyperthyroidism was diagnosed by elevated tri-iodothyronine/thyroxine (T3/T4) ratios and low thyroid-stimulating hormone (TSH) levels, with clinical signs and symptoms. The criteria for surgery were cytological evidence of malignancy, a goiter causing symptoms of tracheal or esophageal compression, side effects of antithyroid drug therapy, or Graves’ disease with multiple relapses after therapy withdrawal or responsiveness to antithyroid drugs. Results: Totally 69 patients were included. In 20 (28.9%) patients there was toxic multinodular goiter, in 28 (40.6%) Graves’s disease, and in 21 (30.5%) patients there was toxic nodular goiter. Of these patients, 12 (17.4%) had thyroid cancer. Conclusions: As a result; low likelihood of malignancy in patients with hyperthyroidism, though suspicious lesions detected in the lymph nodes and neck adenopathies be examined in detail

Peripheral lymphadenopathy in adults: Results of 67 cases of excisional biopsy

Objective: Lymphadenopathy may be the first symptomof many diseases. Enlarged lymph nodes may show significantregional differences in the etiologic profile. In thisstudy we investigated patients with peripheral lymphadenopathydiagnosed by excisional biopsy.Methods: A retrospective study was done of 67 lymphnode biopsy specimens obtained from adult patients andsubmitted for histopathological examination over a 5-yearperiod.Results: The average age of the patients was 37.9±15years, 29 (43.3%) were male. The regions of the lymphadenopathyexcised were axillary (n = 36, 53.7%), inguinal(n = 22, 32.8%), and cervical area (n = 9, 13.4%) respectively.About one-third (n=23; %34.3) of the patientshad malignancies. Malignancies were non-Hodgkin’s lymphoma(n=11, 16.4%), Hodgkin lymphoma (n= 7, 10.4%)and metastases (n = 5, 7.5%), respectively. Tuberculosislymphadenitis (n=20; %29.9) and non-specific lymphadenitis(n=19; %28.4) were the other common causes.Non-specific lymphadenitis included reactive hyperplasia,benign follicular hyperplasia, and mixed follicular hyperplasia.Lymphadenopathy diameter and the presence ofgeneralized lymphadenopathy were significantly higher inmalignant tumors.Conclusion: Although fine-needle aspiration biopsy maybe useful in the differentiation of benign and malignantlymphadenopathies, inability of the diagnosis is often encountered.In addition, an excisional biopsy is needed forthe diagnosis of lymphoma. Excisional biopsy is a diagnosticprocedure that can be applied safely with minimalmorbidity and mortality. On the other hand, especially inpatients with tuberculosis lymphadenopathy incisional biopsyis contraindicated as it can lead to sinus and fistulaformation.Key words: Lymphadenopathy, adults, excisional biops