Advance Ethical Practices in Human Resource Management: A Case Study of Health Care Company

This study set out to examine the advance ethical practices in human resource management. The purpose of this study is to determine the prominence of HRM for a case organization regarding, how ethics and compliances striking it to perform HRM day to day operation more efficiently. This study explains why the extensive involvement of HR in corporate ethics programs is important to the perceived fairness, and thus the likely outcomes. Data collection was carried out through conducting interviews by approaching 12 HR participants. The research findings show that HRM and ethical practices are integrated part of a case organization and hold real prominence to lay down its own code of conduct and motivational ways to foster employees’ better performance.  It is concluded that HR management can influence ethics and fair treatment at work in numerous ways. Implications and few recommendations were also made on the basis of findings. Keywords: Ethics, Code of Ethics, Human Resource Management (HRM

Putative Involvement of Thiol Protease Inhibitor in the Function of Alzheimer Drug

The intermolecular structure gets altered when drug-protein interaction takes place. It brings about alterations in the conformation of protein. An acetyl cholinesterase inhibitor (AChE) is the most used drug for patients who are suffering from Alzheimer’s disease to curb its instigated symptoms. So, it is used as first-line defense in the insightful symptoms. This study is of concern with the interaction of cystatin purified from buffalo brain with its simple tri-step procedure including alkaline action, ammonium sulfate fractionation, and gel filtration chromatography on Sephadex G-75 with % yield of 64.13 and fold purification of 384.7. The inhibitor (brain cystatin (BC)) showed a single papain inhibitory peak drifted as single band on native PAGE; this purified inhibitor was interacted with donepezil to analyze the side effect of this drug since cystatin is an important regulatory protein that maintains the protease antiprotease balance. The conformational change was predicted when the UV spectra of cystatin was analyzed in the presence of donepezil contextual with the fluorescence spectra, but the fluorescence spectra showed 40 nm of red shift suggesting the change on interaction leading to a conclusion that donepezil is pertinent to imbalance to protease and antiprotease inhibitor perhaps the side effect of drug

Elemental analysis of zircon samples from Pacific northwest beaches by INAA

Fifteen sand samples from beaches along the Pacific North were analyzed for their elemental content by the method of instrumental neutron activation analysis (INAA). A separation technique was employed to separate the zircon (a heavy non-magnetic mineral with a specific gravity of 4.67) from the rest of the sample. This technique worked fairly well for most of the samples. The zircon content of the heavy non-magnetic samples was in the range of 58 95%, except for two northern California beaches which contained appreciable quantities of rutile. The hafnium content of the heavy non-magnetic sample was fairly constant. The rare earth pattern in the heavy non-magnetic samples was similar to that observed in geological samples. At present, the Oregon beaches are not economically minable for zircon

CDX-2 expression in colorectal cancer: A single centre study from Pakistan

Introduction:  Tumors of the gastrointestinal (GI) tract, share a major burden for mortality and morbidity all over the world. The most common site of carcinoma of GIT is colon and rectum (70%). The etiological factors may be environmental (diet) and genetic. CDX-2 has been proposed as being present in most of the cases with colorectal carcinoma. Objective: To determine the frequency of positive expression of CDX2 in diagnosed cases of colorectal adenocarcinoma diagnosed on haematoxylin and eosin stain. Material and Methods: This was a cross-sectional study and was conducted at ---(deleted for blind review)--- over period of 2 years We included all paraffin embedded tissue sections of colorectal carcinoma of both genders with an age range of 25-75 years. Specimens were stained with Heamatoxylin and Eosin (H & E) and examined microscopically for presence or absence of invasive cancer. Another specimen was taken and stained with CDX2. The data were analyzed using SPSS version 24. Results: A total of 125 cases with colorectal carcinoma diagnosed on H & E stain were included in the study. The mean age of the patients was found to be 52.66 ± 14.62 years. In this study, 67 patients (53.6%) were male and 58 patients (46.4%) were having final diagnosis of Adenocarcinoma. Regarding the site, most common lesion involved rectum, followed by sigmoid colon and ascending colon. Among 125 specimens reviewed, 112 patients (89.6%) were CDX-2 positive while 13 patients (10.4%) were CDX-2 negative. Also we stratified the CDX-2 expression according to site and type of colorectal carcinoma and was found significant for both of these (P<0.05). Conclusion: We concluded that CDX-2 was present in almost 90% of colorectal carcinoma specimens so it can be used as an important diagnostic tool for colorectal carcinoma during histopathological diagnosis. Keywords: Colorectal carcinoma; CDX-2; Hematoxylin; Eosi

Uptake and acceptability of genetic counselling amongst breast cancer patients and their families in the uMgungundlovu Municipality in 2004.

Master of Medical Science in Public Health Medicine. University of KwaZulu-Natal, Howard College 2015.Awareness of genetic counselling and risk assessment is imperative for women to seek out genetic services. The purpose of this study is to determine the level of genetic counselling and acceptability of genetic counselling by breast cancer survivors, at the time of diagnosis, and the female members of their families, after the diagnosis of the patient within their family, with a view to developing recommendations based on the findings of the study. Two questionnaires were administered to a conveniently selected sample of 48 women; 28 were breast cancer survivors from the Cancer Association of South Africa’s breast cancer support group and 20 women from the general public. Interviews were then conducted with four randomly selected patients and their family members. A total of 12 participants were interviewed: four breast cancer survivors and eight family members, including two spouses and six children. During the interviews one breast cancer patient who was counselled by a psychologist indicated that she was not satisfied with the information she had been given and that further information on the genetics, recurrence, prognosis and family risk should have been provided as she considered this to be essential. The three patients who were not counselled were of the opinion that counselling on the genetics and risks of breast cancer would have been very useful. Four (50%) of the eight family members interviewed, indicated that they were not offered genetic counselling and would not be interested in knowing about the risks associated with breast cancer. Of the remaining four, two (25%) indicated that although they were not offered genetic counselling they would be interested in genetic counselling and learning about the risks associated with breast cancer as such information would be of great value. In terms of a breast cancer risk assessment, four of the eight family members (50%) indicated they were not interested with one further explaining that she might be interested at a later stage. The remaining four family members (50%) indicated their interest in attending a breast cancer risk assessment. In conclusion, educational interventions are required to increase awareness of genetic counselling and risk assessment

Is the war on terror induced-post traumatic stress disorder; the cause of suicide attack? An approach from psycho-cognitive and neurobiological perspective

Understanding suicide attack is one of the highly complicated problems in the field of psychological disorders. Post-traumatic stress disorder (PTSD), may occur in individuals subjected to traumatic assaults like terrorism, warfare, sexual abuse or natural disaster. Individual's living within war affected area often develops PTSD, which may consequently leads to cognitive and memory impairment. The war induced PTSD patient, is under the influence of severe stress; terror and helplessness as it manipulate and retrieve the past trauma as a current threat. Substantial evidences support that PTSD patients are more prone to varying degree of neurological and psychological complications. In this correspondence, we wish to highlight the biological consequence of suicide attack from the perspective of war induced PTSD. Earlier research also supports that PTSD and suicide have some common basis like alterations in hypothalamic pituitary-adrenal axis, nitric oxide and catecholamine like norepinephrine and serotonin level. Thus it is important to uncover the risk of PTSD due to war on terror with precision towards suicide attack and minimize the detriment followed by it. PTSD through the development of depression, irritability and anger, is one amongst the major causes of suicide attack.In order to clarify the underlying psychological mechanism, there is a pressing need to address it from different aspects like disease causing synaptic plasticity and abnormal brain development. PTSD is a reaction to past traumatic events. For instance, the danger of perceived threat due to witness of deaths in a war, may develop a constellation of properties that may leads to PTSD. Usually, it initiates a sequence of behavioral and cognitive changes that can be anticipated to reduce the perceived threat. However, the consequences of perceived threat lead to cognitive changes and thus maintain a devastating disorder. Appraisals of such memory not only generate situational fear but also the avoidance, which leads to enhanced trepidation and over-activity. For example, a person exposed to a road side traumatic accident may avoid driving; for having an impractical faith that it may happen again, thereby affecting its social life.Patients suffering from PTSD due to war may interpret that the trauma will persist for long time and thus he is no longer safe. He or she may suffer from depression, irritability, anger outbursts, emotional numbing, flashbacks, and nightmares [1]. It has been reported that numbing is an ordinary reaction to traumatic events. Individuals should realize that it is a normal aspect of the recovery process, otherwise it can lead to permanent changes which may worsen their physical or psychological well-being [2-4]. Children experiencing the PTSD, usually underwent alterations in hypothalamic-pituitary-adrenal axis, catecholamine and norepinephrine, which results in pathological and detrimental brain development [5]. Interestingly, the inhibition of nitric oxide in hippocampus by antidepressant has promising outcome to alleviate the PTSD symptoms [6]. While, the augmented level of plasma nitrates in depressive patients are found to be associated with suicide attempts [7].Figure 1The intention of a suicide attack is to kill a large crowd or bringing mass destruction, even with the notion that he will die in this act. Suicide bombings termed as "suicide bombing" constitute an overall 4% of terrorist attacks, which dates back to the beginning of the 19th century. In most of the modern suicide terrorist is used against non-combatants for the accomplishment of impact on political situation. Although a suicide attack aims to annihilate a primary target, however it can be used as a weapon of psychological warfare to affect the large public population. The main target of this action is not those who are killed but those witnessed it [8]. Intriguingly, it is reported that the level of brain-derived neurotropic factor (BDNF) is directly associated with suicide while indirectly it can affect PTSD. Also, defining body of research proved that altered level of serotonin in dorsal raphe nucleus, amygdala, median raphe, frontal cortex, hypothalamus and hippocampus is associated with aggressive behavior and suicide [9]. PTSD-induce symptoms like impulsivity, violence, suicide attempts, depression, panic, and anxiety can also be associated with altered serotonin levels [10].ConclusionThe mechanism of suicide attack is still highly debated; and need much more to address. Since, PTSD through the development of depression, irritability and anger, accomplish various physiological and cognitive changes in the brain, so it might be one of the causes which increases the susceptibility of acceptance for being a volunteer to suicide attack? This discussion was put forward; as some war induced PTSD patients among temporary displaced people in different regions of the world showed strong willingness for suicide attack as a counter revenge of war. Therefore, we also need to address suicide attack from the perspective of psychological disorders like war induced PTSD