Manéhouville – Hameau de Calnon

Le passage à 2 × 2 voies de la RN 27 reliant Rouen à Dieppe a nécessité la mise en place en 2011 d’un diagnostic archéologique sur un peu plus de 50 ha (D. Breton, Inrap). Seule une surface de 2 ha à hauteur de Manéhouville, hameau de Calnon, a été concernée par la fouille. Les parcelles fouillées se situent à une vingtaine de kilomètres au sud de Dieppe, sur un plateau légèrement déversant. En contre-haut de la vallée de la Scie, dans un contexte plus ou moins érodé et acide, la conservation..

Investigating the role of nuclear encoded mitochondrial genes in the onset of type 2 diabetes

Mitochondrial dysfunction has long been implicated in Type 2 diabetes (T2D). This rela- tionship appears to be bidirectional, with evidence that mitochondrial dysfunction is both caused by and causal of T2D-related phenotypes. A potential causal role in T2D onset would be supported by evidence of a genetic predisposition to mitochondrial dysfunction, since inherited genetic risk factors precede and contribute to disease onset. Here, a genetic study design is used to investigate the potential role of T2D-associated genetic risk loci (T2D loci) in disrupting mitochondrial function through the altered expression of nuclear- encoded mitochondrial genes (NEMGs). The mitochondria are targeted by multiple T2D drugs and therefore such loci may be informative for effective treatment and prevention measures. The functional cis–genes regulated by T2D loci were identified based on the co-location of T2D loci with adipose tissue expression quantitative trait (eQTL) within a genetic distance of 1 LDU. T2D loci and eQTL were previously mapped using LDU- based gene mapping, which is compared and contrasted in this thesis to other popular tests of association. 50 of the identified T2D cis–genes were NEMGs and implicated a number of pathways in the inherited risk of T2D, including the relevant pathway of branched-chain amino acid catabolism. These same 50 genes were enriched for decreased expression in T2D cases compared to controls in independent gene expression datasets. Compared to the total known NEMGs, the 50 cis-NEMGs showed further enrichment for decreased expression, suggesting that T2D-eQTL co-location may identify specific subsets of causal genes. Finally, a candidate T2D locus associated with the cis–NEMG ACAD11 was fine-mapped using targeted sequence data for 94 T2D cases and 94 controls. Sev- eral candidate causal variants were identified, including two low-frequency haplotypes, one of which contained both an ACAD11 splicing mutation and a mutation predicted to disrupt the observed binding of HNF4A and COUP-TFII within the ACAD11 promoter region.Open Acces

Negative Affect and Problematic Binge-Watching: The Mediating Role of Unconstructive Ruminative Thinking Style

The practice of binge-watching (i.e., watching multiple episodes of TV series in one session) has become increasingly prevalent, but comprehending its nature and potential underlying factors has been challenging. In particular, problematic binge-watching remains ill-defined and conceptualized, being regarded either as an addictive behaviour or a maladaptive emotion regulation strategy. Following a process-based approach, in the current study we explored the latter conceptualization, by investigating the potential mediating role of an unconstructive ruminative thinking style between negative affect and problematic binge-watching. To this end, TV series viewers completed an online survey assessing socio-demographic variables, TV series viewing habits, binge-watching motives and engagement, ruminative thinking styles and affect. Based on their answers, participants were allocated to one of the following three groups: non-binge-watchers (n = 59), trouble-free binge-watchers (n = 85), or problematic binge-watchers (n = 162). Group comparisons and mediation analyses were conducted to explore the underlying role of unconstructive rumination in problematic binge-watching. Results showed that, apart from the pattern of TV series watching, trouble-free binge-watchers shared little to no similarity with problematic binge-watchers, therefore supporting the need to differentiate these two behaviours. Moreover, mediation analyses revealed that an unconstructive ruminative thinking style partially mediated the relationship between negative affect and coping/escapism and that it fully accounted for the relationship between negative affect and binge-watching derived positive emotions in problematic binge-watchers. These findings thus add to the notion that problematic binge-watching might serve as a way to bolster a maladaptive emotion regulation strategy, implying that unconstructive rumination acts as a mediating process in this context