Lattice Thermal Conductivity: A Comparison of Molecular Dynamics and Anharmonic Lattice Dynamics,” Phys.

The thermal conductivity of a monatomic face-centered-cubic lattice has been calculated over a range of temperatures from one-twentieth to one-half the melting temperature. An inverse-twelfth power "soft-sphere" potential was used to represent the interatomic forces. We have examined, quantitatively, the approximations involved in deriving the Peierls phonon-transport expression for the thermal conductivity and have determined the temperature range over which it is useful. This has involved extensive comparisons with the formally exact Green-Kubo method, using molecular dynamics to generate the phase-space trajectories. At low temperatures, the relaxation processes in a crystal can be described in terms of phonon lifetimes. We have calculated the lifetimes of all the phonon states of 108-, 256-, and 864-particle classical crystals, with periodic boundaries, by molecu lar dynamics and by anharmonic perturbation theory. These lifetimes were then used to estimate the thermal conductivity.~

The Role of Hypoxia in 2-Butoxyethanol–Induced Hemangiosarcoma

To understand the molecular mechanisms underlying compound-induced hemangiosarcomas in mice, and therefore, their human relevance, a systems biology approach was undertaken using transcriptomics and Causal Network Modeling from mice treated with 2-butoxyethanol (2-BE). 2-BE is a hemolytic agent that induces hemangiosarcomas in mice. We hypothesized that the hemolysis induced by 2-BE would result in local tissue hypoxia, a well-documented trigger for endothelial cell proliferation leading to hemangiosarcoma. Gene expression data from bone marrow (BM), liver, and spleen of mice exposed to a single dose (4 h) or seven daily doses of 2-BE were used to develop a mechanistic model of hemangiosarcoma. The resulting mechanistic model confirms previous work proposing that 2-BE induces macrophage activation and inflammation in the liver. In addition, the model supports local tissue hypoxia in the liver and spleen, coupled with increased erythropoeitin signaling and erythropoiesis in the spleen and BM, and suppression of mechanisms that contribute to genomic stability, events that could be contributing factors to hemangiosarcoma formation. Finally, an immunohistochemistry method (Hypoxyprobe) demonstrated that tissue hypoxia was present in the spleen and BM. Together, the results of this study identify molecular mechanisms that initiate hemangiosarcoma, a key step in understanding safety concerns that can impact drug decision processes, and identified hypoxia as a possible contributing factor for 2-BE–induced hemangiosarcoma in mice

Resolving Individuals Contributing Trace Amounts of DNA to Highly Complex Mixtures Using High-Density SNP Genotyping Microarrays

We use high-density single nucleotide polymorphism (SNP) genotyping microarrays to demonstrate the ability to accurately and robustly determine whether individuals are in a complex genomic DNA mixture. We first develop a theoretical framework for detecting an individual's presence within a mixture, then show, through simulations, the limits associated with our method, and finally demonstrate experimentally the identification of the presence of genomic DNA of specific individuals within a series of highly complex genomic mixtures, including mixtures where an individual contributes less than 0.1% of the total genomic DNA. These findings shift the perceived utility of SNPs for identifying individual trace contributors within a forensics mixture, and suggest future research efforts into assessing the viability of previously sub-optimal DNA sources due to sample contamination. These findings also suggest that composite statistics across cohorts, such as allele frequency or genotype counts, do not mask identity within genome-wide association studies. The implications of these findings are discussed

Visitors from Louisville Are Impressed

Article by the Louisville Courier-Journal reporter Bill Ladd reprinted in the College Heights Herald. (Ed. Note: Bill Ladd, who witnessed the Western - U. of L. fracas Saturday night, summed up the week-end festivities in Tuesday\u27s Courier Journal in the following manner.) Nice time in Bowling Green Saturday at the University of Louisville-Western game. Not much of a contest, but as an exhibition it was wonderful . . . Admirers of the Western team, and they are numbered in large, coarse figures, say the club never has been hotter . . .Expect they will play in the Armory again this year before the tournament . . Rumor at Bowling Green was that Irving Wayne, Armory manager, has signed them to meet any team he selects for them . . . The glass banking boards are gone at the Western gym . . . One of them exploded during practice, flying glass covered the floor and cut a couple of ball players slightly . . . Lucky it didn\u27t happen during a game. . . . They don\u27t allow smoking in the Western gym and they get away with it, too . . . Coach Diddle, great story-teller, regaled a party at WLBJ\u27s beautiful radio station after the game with tales of Bo McMillin days at Centre . . . Eddie Diddle, coach\u27s son at College High there, is a great prospect, they say, made 20 points Saturday night . . Coach says he isn\u27t going to Western, but Kelly Thompson says he is . . . Kelly would like to write about the father-and-son combination . . . Paul Garrett, president of the school, had a smile as wide as the basket while his boys were pouring in shots Saturday . . . Big game at Western used to be with Murray, but now the Louisville game is replacing it . . . During the Brigham Young game a Utah player was taken out of the game and as he came to his bench a great laugh went up from the seats behind him. Seems the coach met him at the edge of the floor and asked why he had so little success in guarding Odie Spears, who has a very peculiar shot. He sort of falls away from the basket and kicks his feet high to the rear. How can you do anything with a goon like that? the player complained in a loud voice. He shoots over your heard and then kicks your teeth out at the same time.https://digitalcommons.wku.edu/online_ex_helm/1160/thumbnail.jp