Implementation of Nanoparticles in Cancer Therapy

WOS: 000364531600019Cancer is a wide group of diseases and generally characterized by uncontrolled proliferation of cells whose metabolic activities are dtsrupted. Conventionally, chemotherapy, radiotherapy, and surgery are used in the treatment of cancer. However. in theory, even a sing/c cancer ce/I may trigger recurrence. The ref ore, these treatments cannot provide high survival rate for deadly types. Identijication of alternative methods in treatment of cancers is inevitable because of adverse effucts of con ventiona/methods. In the last few decades, nanotechnology developed by scientists working in different disciplines physics. chemistry, and biology offers great opportunities. It is providing elimination of both circulating tumor cei/.v and solid cancer cells by taryeting cancer cells. In this chaptem; inadequate parts of conventional treatment methods, nanoparlicie types used in new treatment methods of cancer. and targeting methods of nanopartic/es are summarized: furthermore, recommendations of future are provided

Optimization of bacterial cellulose production by Gluconacetobacter xylinus using carob and haricot bean

International Biomedical Engineering Congress -- 2015 -- Near E Univ, North Nicosia, CYPRUSWOS: 000380626900002PubMed ID: 26906562Bacterial cellulose (BC) can be used in medical, biomedical, electronic, food, and paper industries because of its unique properties distinguishing it from plant cellulose. BC production was statistically optimized by Gluconacetobacter xylinus strain using carob and haricot bean (CHb) medium. Eight parameters were evaluated by Plackett-Burman Design and significant three parameters were optimized by Central Composite Design. Optimal conditions for production of BC in static culture were found as: 2.5 carbon source, 2.75 g/L protein source, 9.3% inoculum ratio, 1.15 g/L. citric acid, 2.7 g/L Na2HPO4, 30 degrees C incubation temperature, 5.5 initial pH, and 9 days of incubation. This study reveals that BC production can be carried out using carob and haricot bean extracts as carbon and nitrogen sources, and CHb medium has higher buffering capacity compared to Hestrin and Schramm media. Model obtained from this study is used to predict and optimize BC production yield using CHb medium. (C) 2016 Elsevier B.V. All rights reserved

Bacterial cellulose based facial mask with antioxidant property and high moisturizing capacity

Bacterial cellulose (BC) produced by certain bacteria has the potential to be used in many different areas. Despite its advantageous properties compared to plant cellulose, such as high purity, mechanical strength, nanofiber mesh structure, and high-water holding capacity, its production through a biotechnological process prevents it from competing with plant counterparts in terms of cost-effectiveness. Therefore, studies have focused on the development of culture media with cost-effective BC production methods and the production of high value-added products from BC. In this study, it was aimed to develop a taurine-loaded moisturizing facial mask with antioxidant properties based on BC's high-water retention and chemical retention capacity. BC facial mask samples were characterized by Scanning Electron Microscopy (SEM) imaging, Fourier Transform Infrared (FTIR) Spectroscopy, Differential Scanning Calorimetry (DSC), Liquid Chromatography-Mass spectrometry (LC-MS), microbial and mechanical stability tests, as well as cytotoxicity tests. According to our results, produced facial mask samples did not show any cytotoxic effect on human keratinocyte (HS2) or mouse fibroblast (L-929) cell lines; it has high thermal stability, which makes it suitable for different sterilization techniques including sterilization by heat treatment. Taurine release (over 2 mu g/mL in 5 min) and microbial stability tests (no bacterial growth observed) of packaged products kept at 40 and 25 degrees C for 6 months have shown that the product preserves its characteristics for a long time. In conclusion bacterial cellulose-based facial masks are suitable for use as a facial mask, and they can be used for moisturizing and antioxidant properties by means of taurine.Republic of Turkey, Ministry of Industry and Technology [0198-STZ-2013-1]; Ege University Science and Technology Center [2014/BIL/015]; BioRed Laboratory Products Company [0198-STZ-2013-1]Republic of Turkey, Ministry of Industry and Technology and BioRed Laboratory Products Company (0198-STZ-2013-1); Ege University Science and Technology Center (2014/BIL/015)