7 research outputs found
Selenium Treatment and Chagasic Cardiopathy (STCC): study protocol for a double-blind randomized controlled trial
- Author
- A Gasmi
- A Rassi Jr
- AL Kavanaugh-McHugh
- Alejandro Marcel Hasslocher-Moreno
- AMB Bilate
- Andréa Pereira de Souza
- Andréa Silvestre de Sousa
- AP de Souza
- AP de Souza
- AP de Souza
- B Contempré
- BM Dworkin
- BY Lee
- C Köppel
- CD Davis
- Claudia Santos de Aguiar Cardoso
- Constança Britto
- CR Fleming
- FS Machado
- FS Machado
- G Li
- G Salles
- G Yang
- Gilberto Marcelo Sperandio da Silva
- GQ Yang
- H Koehler
- ID Civil
- J Borges-Pereira
- J Loscalzo
- JD Bogden
- JH McDermott
- JR Coura
- JT Salonen
- KKA Witte
- M de Lorgeril
- M Manary
- MA Zacks
- Maria da Gloria Bonecini de Almeida
- Maria de Fátima Ramos Moreira
- Marília Santini de Oliveira
- Mauro Felippe Felix Mediano
- Ministério da Saúde Secretaria de Vigilância em Saúde
- MP Fleck
- MP Rayman
- MT Rivera
- Otacílio da Cruz Moreira
- P Suadicani
- PA Harris
- Pedro Emmanuel Alvarenga Americano do Brasil
- R Development Core Team
- R Moreno-Reyes
- R Thiele
- RA Quercia
- RF Carter
- RL Prentice
- RM Gomez
- RM Lang
- Roberto Magalhães Saraiva
- Sonia Regina Lambert Passos
- SS Kothari
- Sérgio Salles Xavier
- Tania Cremonini de Araújo-Jorge
- TC Stadtman
- TRJ Gianduzzo
- WC Hawkes
- WC Reeves
- Y Saito
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Chagas disease reactivation in rheumatologic patients: association with immunosuppressive therapy and humoral response
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Análise da eficácia do laser de baixa potência no tratamento da dor tendínea em ratos imunossuprimidos Analysis of low-level laser therapy efficacy on tendon pain treatment in immunosuppressed rats
- Author
- Publication venue
- Universidade de São Paulo
- Publication date
- 01/12/2011
- Field of study
O comprometimento do sistema imune, que pode ser apresentado por indivíduos com doenças crônicas, leva à baixa resposta imunológica. Um dos tratamentos utilizados para lesões agudas em tendões é o laser de baixa potência, contudo há uma lacuna em relação ao seu uso em imunodepressão. O objetivo do presente estudo foi analisar se o laser de baixa potência é eficaz para o tratamento da dor em ratos imunodeprimidos submetidos a trauma tendíneo. Foram utilizados 23 ratos, machos, da linhagem Wistar, divididos aleatoriamente em três grupos: grupo controle, placebo e laser. Os animais foram imunodeprimidos (por administração de Ciclosporina A) e submetidos à lesão no tendão calcâneo direito, com impacto de cerca de 0,40 J. Para o tratamento, utilizou-se laser de baixa potência, 670 nm, 30 mW e dose de 2 J/cm², durante 3 dias. A avaliação da dor foi realizada pelo teste de incapacidade funcional e por filamento de Von Frey digital. Os resultados apresentaram valores significativos para o grupo laser, com diminuição de dor funcional e da dor à pressão na superfície plantar e no local lesionado (tendão calcâneo direito). Portanto, concluiu-se que o laser de baixa potência é eficaz para reduzir a dor em ratos imunodeprimidos submetidos a trauma tendíneo.<br>The commitment of immune system, which may be presented by individuals with chronic diseases, leading to a low immune response. One of the treatments used for acute injuries in tendons is the low-power laser, however there is a gap in relation to its use in immunosuppression. The objective of this study was to analyze if low-level laser therapy is effective for the treatment of pain in immunosuppressed rats subjected to trauma tendon. We used 23 male rats of Wistar strain, divided randomly in three groups: control group, placebo and laser. The animals were immunosuppressed (by administration of Cyclosporin A) and underwent right Achilles tendon injury, with impact of about 0.40 J. For treatment, we used low-level laser, 670 nm, 30 mW and 2 J/cm², during 3 days. Pain assessment was performed by the functional incapacitation test and von Frey filament digital. The results showed a reduction of functional pain and pressure pain on the plantar surface and the injured site (right Achilles tendon) for the laser group. Therefore, we concluded that the low-power laser is effective for reducing pain in immunosuppressed rats subjected to trauma tendon
Chagas’ heart disease: gender differences in myocardial damage assessed by cardiovascular magnetic resonance
- Author
- A Rassi
- A Regueiro
- Alejandra V. Mauricio
- AMB Bilate
- Antonildes N. Assunção
- AT Yan
- B Ambale Venkatesh
- Barbara M. Ianni
- C Bern
- Carlos E. Rochitte
- CE Rochitte
- Charles Mady
- CJC Bastos
- D Bello
- E Perez-David
- EA Bocchi
- EC Sabino
- Fabio Fernandes
- J Schulz-Menger
- JA Marin-Neto
- JA Torreão
- JC Prado júnior do
- Jorge A. Torreão
- José A. F. Ramires
- JP Schuster
- KC Wu
- L Iles
- Liliane Rocha
- M Kubanek
- MA Shikanai-Yasuda
- ME Sobel
- Michael Jerosch-Herold
- ML Higuchi
- N Kawel-Boehm
- PG Masci
- R Baron
- R Hoff
- R Kalil
- RA Guerri-Guttenberg
- Roberto Kalil-Filho
- Rodrigo L. Melo
- RP Mello de
- S Kuruvilla
- TG Neilan
- Y Yang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Elevated serum levels of macrophage migration inhibitory factor are associated with progressive chronic cardiomyopathy in patients with Chagas disease.
- Author
- A Biolo
- A Rassi Jr
- A Sher
- A Talvani
- A Zernecke
- AMB Bilate
- AO Mocelin
- C Junqueira
- CA da Silva
- CA Terrazas
- CM Yu
- CN Paiva
- D Qi
- DD Reis
- E Girard
- E Kuschnir
- Edgardo Schapachnik
- EF Morand
- EG Regis
- FA Bozza
- G Yamada
- Guillermo H. Giambartolomei
- H Cuervo
- H Luo
- HA Molina
- II Müller
- J Bernhagen
- J Bernhagen
- J Vogt
- JA Gomes
- JA Marin-Neto
- JD Rosado
- JJ Wen
- JJ Wen
- JL Gregory
- JL Gregory
- JL Hardison
- JL Ho
- JL Reyes
- JR Santos-Oliveira
- K Kimura
- K Wakabayashi
- KD Simpson
- L Leng
- M Bergeron
- M Dhiman
- M Postan
- MA McDevitt
- MA Muñoz-Fernández
- Mariela N. González
- MD Higuchi
- MG Cavalcanti
- Miriam Postan
- ML Higuchi
- MM Camargo
- O Flieger
- Patricia B. Petray
- PF Chen
- RA Cutrullis
- Ricardo S. Corral
- RL Tarleton
- Romina A. Cutrullis
- RP Donn
- Rubén Sánchez
- S Gupta
- S Gupta
- S Hagman
- SA Drigo
- T Calandra
- T Calandra
- V Braunersreuther
- V Jain
- Valentina Martín
- VM Lorena
- X Shi
- XH Yu
- XY Yu
- Y Matsui
- YC Chuang
- Publication venue
- Public Library of Science (PLoS)
- Publication date
- 01/01/2013
- Field of study
Clinical symptoms of chronic Chagas disease occur in around 30% of the individuals infected with Trypanosoma cruzi and are characterized by heart inflammation and dysfunction. The pathogenesis of chronic chagasic cardiomyopathy (CCC) is not completely understood yet, partially because disease evolution depends on complex host-parasite interactions. Macrophage migration inhibitory factor (MIF) is a pleiotropic proinflammatory cytokine that promotes numerous pathophysiological processes. In the current study, we investigated the link between MIF and CCC progression.Immunohistochemical analysis demonstrated MIF overexpression in the hearts from chronically T. cruzi-infected mice, particularly those showing intense inflammatory infiltration. We also found that MIF exogenously added to parasite-infected murine macrophage cultures is capable of enhancing the production of TNF-α and reactive oxygen species, both with pathogenic roles in CCC. Thus, the integrated action of MIF and other cytokines and chemokines may account for leukocyte influx to the infected myocardium, accompanied by enhanced local production of multiple inflammatory mediators. We further examined by ELISA the level of MIF in the sera from chronic indeterminate and cardiomyopathic chagasic patients, and healthy subjects. CCC patients displayed significantly higher MIF concentrations than those recorded in asymptomatic T. cruzi-infected and uninfected individuals. Interestingly, increased MIF levels were associated with severe progressive Chagas heart disease, in correlation with elevated serum concentration of high sensitivity C-reactive protein and also with several echocardiographic indicators of left ventricular dysfunction, one of the hallmarks of CCC. Our present findings represent the first evidence that enhanced MIF production is associated with progressive cardiac impairment in chronic human infection with T. cruzi, strengthening the relationship between inflammatory response and parasite-driven pathology. These observations contribute to unravel the elements involved in the pathogenesis of CCC and may also be helpful for the design of novel therapies aimed to control long-term morbidity in chagasic patients
Elevated Serum Levels of Macrophage Migration Inhibitory Factor Are Associated with Progressive Chronic Cardiomyopathy in Patients with Chagas Disease
- Author
- A Biolo
- A Rassi Jr
- A Sher
- A Talvani
- A Zernecke
- AMB Bilate
- AO Mocelin
- C Junqueira
- CA da Silva
- CA Terrazas
- CM Yu
- CN Paiva
- D Qi
- DD Reis
- E Girard
- E Kuschnir
- Edgardo Schapachnik
- EF Morand
- EG Regis
- FA Bozza
- G Yamada
- Guillermo H. Giambartolomei
- H Cuervo
- H Luo
- HA Molina
- II Müller
- J Bernhagen
- J Bernhagen
- J Vogt
- JA Gomes
- JA Marin-Neto
- JD Rosado
- JJ Wen
- JJ Wen
- JL Gregory
- JL Gregory
- JL Hardison
- JL Ho
- JL Reyes
- JR Santos-Oliveira
- K Kimura
- K Wakabayashi
- KD Simpson
- L Leng
- M Bergeron
- M Dhiman
- M Postan
- MA McDevitt
- MA Muñoz-Fernández
- Mariela N. González
- MD Higuchi
- MG Cavalcanti
- Miriam Postan
- ML Higuchi
- MM Camargo
- O Flieger
- Patricia B. Petray
- PF Chen
- RA Cutrullis
- Ricardo S. Corral
- RL Tarleton
- Romina A. Cutrullis
- RP Donn
- Rubén Sánchez
- S Gupta
- S Gupta
- S Hagman
- SA Drigo
- T Calandra
- T Calandra
- V Braunersreuther
- V Jain
- Valentina Martín
- VM Lorena
- X Shi
- XH Yu
- XY Yu
- Y Matsui
- YC Chuang
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
Cardiovascular Activity
- Author
- A Baartscheer
- A Baartscheer
- A Baartscheer
- A Bachmann
- A Bauer
- A Bergdahl
- A Bezold von
- A Biedl
- A Bomzon
- A Bonnacrossi
- A Braillon
- A Brkovic
- A Brueggemann
- A Brüggemann
- A Bucchi
- A Capri
- A Carmeliet
- A Carotenuto
- A Cavalié
- A Cavalli
- A Chatelier
- A Chu
- A Claing
- A Daugherty
- A Daugherty
- A Daugherty
- A Ezzaher
- A Fabiato
- A Fleckenstein
- A Fleckenstein
- A Fleckenstein
- A Fleckenstein
- A Fleckenstein
- A Fleckenstein
- A Gagliardi
- A Genao
- A Genovese
- A Gibson
- A Gibson
- A Gibson
- A Goll
- A Grassegger
- A Graziani
- A Grollman
- A Haugan
- A Hedberg
- A Helman
- A Hilditch
- A Hilditch
- A Hilditch
- A Hislop
- A Hislop
- A Hutchaleelaha
- A Inoue
- A Inoue
- A Inoue
- A Jarisch
- A Jarisch
- A Jarisch
- A Karlin
- A Kasai
- A Kochhar
- A Lerman
- A Lopez de Leon
- A Luchner
- A Luchner
- A Lückhoff
- A Lückhoff
- A Malhotra
- A Marchese
- A Marjamäki
- A Marmarou
- A Mattes
- A McRae
- A Menargues
- A Miwa
- A Molteni
- A Molteni
- A Molteni
- A Molteni
- A Monopoli
- A Morita
- A Mülsch
- A Nygren
- A Osajima
- A Reaux
- A Reaux
- A Rudolph
- A Rutledge
- A Salimbeni
- A Sanbe
- A Sattin
- A Schuster
- A Schömig
- A Sculptoreanu
- A Sgoifo
- A Shiroshita-Takeshita
- A Stirrat
- A Sunami
- A Tajima
- A Tamura
- A Terzic
- A Tzanidis
- A Vacca
- A Vacca
- A Vaille
- A Vegh
- A Vegh
- A Verma
- A Volovsek
- A Wahhab
- A Ward
- A Wollenberger
- A Woppmann
- A Wright
- A Yu
- AA Andreadis
- AA Kochegarow
- AA Owji
- AA Pieper
- AB Fawzi
- AB Schreiber
- AB Schreiber
- AB Steffens
- AC Chiou
- AC Dolphin
- AC MacKinnon
- AC MacKinnon
- AC Sulpizio
- ACG Uprichard
- ACG Uprichard
- AD Medhurst
- AD Michel
- AD Michel
- AD Muskett
- AD Muskett
- AE Busch
- AE Busch
- AE Freedlender
- AE RiberoMO
- AEFH Meijer
- AF Green
- AF Green
- AF Green
- AF Green
- AF Green
- AF Odell
- AF Prigent
- AF Prigent
- AG Ciplea
- AGB Kovâch
- AH Cohen
- AH Gradman
- AH Nielsen
- AH Werber
- AH Weston
- AI Faden
- AI Faden
- AI Khan
- AIM Al-Shafei
- AIM Al-Shafei
- AJ Balmforth
- AJ Bold De
- AJ Carter
- AJ Carter
- AJ D’Alonzo
- AJ Gower
- AJ Gower
- AJ Hutchinson
- AJ Kaumann
- AJ Kielblock
- AJ King
- AJ Newell
- AJ Nichols
- AJ Pijl
- AJ Rice
- AJ Susswein
- AJ Szentmiklósi
- AJ Trapani
- AJ Turner
- AK Fouda
- AK Ommaya
- AK Salyers
- AL Blatz
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- AM Beaufort
- AM Broadhurst
- AM Doherty
- AM Duncan
- AM Ehrly
- AM Feldman
- AM Feldman
- AM Gomez
- AM Hackett
- AM Joussen
- AM Lands
- AM Lands
- AM Lands
- AM Lands
- AM Oliveira
- AM Peier
- AM Peier
- AM Romanic
- AM Vineberg
- AM Watson
- AMB Bilate
- AMD Watson
- AN Santos
- AP Albert
- AP Davenport
- AP Ijzerman
- AP Moreno
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- AW Richardson
- AY Jeng
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- AYW Chang
- B Anner
- B Badio
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- B Christophe
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- B Malinowska
- B Martin-McNulty
- B Masri
- B Masri
- B Meyrick
- B Meyrick
- B Meyrick
- B Meyrick
- B Müller
- B Nilius
- B Nilius
- B Nilius
- B O’Rourke
- B Peruche
- B Rubin
- B Rubin
- B Sakmann
- B Surawicz
- B Tantini
- B Vannier
- B Vannier
- B Waldeck
- B Wiegershausen
- B Zander
- BA MacLeod
- BA Nassar
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- BB Clark
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- C Advenier
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- W Feldberg
- W Feldberg
- W Fischli
- W Grossman
- W Hsueh
- W Häuser
- W Isola
- W Kobinger
- W Liedtke
- W Linz
- W Linz
- W Linz
- W Linz
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- W Linz
- W Linz
- W Linz
- W Linz
- W Linz
- W Linz
- W Linz
- W Linz
- W Linz
- W Linz
- W Martin
- W Meesmann
- W Meesmann
- W Penz
- W Pettinger
- W Schallek
- W Schaper
- W Schaper
- W Scholz
- W Scholz
- W Scholz
- W Scholz
- W Scholz
- W Scholz
- W Scholz
- W Scholz
- W Scholz
- W Scholz
- W Scholz
- W Scholz
- W Schoner
- W Song
- W Spinelli
- W Sun
- W Tornatzky
- W Vine
- W Vleeming
- W Wienen
- WA Catterall
- WA Catterall
- WA Catterall
- WA Catterall
- WA Mann
- WA Pulsinelli
- WB Stam
- WC Bowman
- WC Bowman
- WC Ko
- WD Heiss
- WE Jacobus
- WF Lubbe
- WG Anderson
- WH Beinfield
- WH Gilst van
- WH Gilst van
- WH Gilst van
- WH Zhu
- Wienen W Hauel N, van Meel JCA, Narr B, Ries U, Entzeroth M (1993) Pharmacological characterization of the novel nonpeptide angiotensin II receptor antagonist, BIBR 277. Br J Pharmacol 110:245–252 Wong PC, Quan ML, Saye JAM, Bernard R, Crain EJ Jr, Nc- Call DE, Watson CA, Zaspel AM, Smith RD, Wexler RR, Timmermans PBMWM, Chiu AT
- WJ ChicagoCrumb Jr
- WJ Chiou
- WJ Greenlee
- WJ Greenlee
- WJ Linz
- WJ Rossowski
- WJ Rossowski
- WJ Thompson
- WK Samson
- WL Miller
- WL Rosenberg
- WLF WolffMR
- WM Vogel
- WN Tapp
- WP Schilling
- WR Huckle
- WR Tracey
- WT Chiu
- WW Brooks
- X Cheng
- X Joseph
- X Li
- X Monnet
- X Su
- X Xin
- X Xin
- X Xu
- X Zhang
- XH Gu
- XM Yang
- XP Yang
- XY Lu
- XZ Xu
- XZ Xu
- Y Aoki
- Y Bi
- Y Blaauw
- Y Blaauw
- Y Coulouarn
- Y Deng
- Y Dumont
- Y Funahashi
- Y Guo
- Y Guo
- Y Hamma-Kourbali
- Y Hashimoto
- Y Hayashi
- Y Huang
- Y Huang
- Y Ishida
- Y Ishiyama
- Y Isumi
- Y Kambayashi
- Y Kamisaki
- Y Katano
- Y Lebedinsky
- Y Magata
- Y Maruyama
- Y Meur Le
- Y Murakawa
- Y Naka
- Y Nishimura
- Y Nozawa
- Y Nozawa
- Y Nozawa
- Y Nozawa
- Y Ogawa
- Y Pommier
- Y Qiu
- Y Saishin
- Y Salomon
- Y Shibouta
- Y Suzuki
- Y Takai
- Y Takano
- Y Takata
- Y Takuwa
- Y Tamura
- Y Trolese-Mongheal
- Y Trolese-Mongheal
- Y Urade
- Y Urade
- Y Urade
- Y Wan
- Y Wan
- Y Yamori
- Y Yamori
- Y Yang
- Y Yonezawa
- Y Yonezawa
- Y Yu
- Y-C Tong
- Y-J Cao
- Y-P Tang
- YC Cheng
- YC Cheng
- YC Cheng
- YC Cheng
- YC Cheng
- YC Cheng
- YH Chan
- YH Liu
- YH Liu
- YH Liu
- YJ Liu
- YL Lai
- YL Lai
- YL Li
- YM Lin
- YM McDonaldKM
- YM Pinto
- YP Vedernikov
- YP Vedernikov
- YP Wu
- YS YildirimMK
- YT Sia
- YX Wang
- YX Wang
- YX Wang
- Z Liu
- Z Shan
- Z Szilvássy
- Z Vogel
- Z Wang
- Z Wang
- Z Yang
- Z Yang
- Z Yao
- ZA Damanhouri
- ZI Terashita
- ZM Chu
- ZS Ercan
- ZS Ercan
- ZS Herman
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2007
- Field of study