Neck and Back Pain Prevalence in Workers of Iranian Steel industries at 2015

Work related musculoskeletal disorders (WMSDs) are considered as the main cause of occupational complications and disability in developing countries. In Iranian steel companies, workers commonly are directly involved in the production process and physical activities such as manual material handling and awkward postures. Present study was performed for assessment of neck and back pain prevalence among workers of four Iranian steel industries. Study participants in our cross sectional study, were randomly selected from workers of four Iranian steel industries. Data of neck and back pain were gathered by Nordic questionnaire. Logistic regression was used for controlling confounding variables and determining independent predictors of neck and back pain among study workers. Among study workers, prevalence of neck and back pain in a recent year were 18.40% and 13.90% respectively. Age (p≤0.02) and job experience (p≤0.00) had significant association with neck pain. Age, sex, BMI, and job duration were not known as an independent predictor of neck or back pain. Neck and back pain prevalence in steel industries were happened whit higher rate compared to most of other countries. Next studies will suggest for determining work related risk factors of WMSDs in workers and designing preventive strategies

Pattern of trauma related to falling from walnut tree as an occupational injury: A cross-sectional study in the west of Iran

Background: Evidence regarding the epidemiological characteristics and the mechanisms of trauma related to falling from walnut tree are limited in Iran. Therefore, this study was conducted to investigate the pattern of trauma related to falling from walnut tree as an occupational injury in Tuyserkan in the west of Iran in 2017. Materials and Methods: In this cross-sectional study, all the patients admitted in Vali-Asr Hospital for injuries caused by falling from walnut trees during the harvest for walnuts (from September to October 2017) were reviewed. The data were collected by a checklist including the demographic and clinical characteristics of the patients obtained from the hospital records. Data were analyzed using descriptive and analytical statistics by the STATA software version 12. Results: During the study, a total of 52 injured cases were registered in Vali-Asr Hospital. All patients were male, and 71.2 of them were rural dwellers. Falls were more concentrated in Friday (27) and peaked in mid-days (19.2 of cases). Branch breaking was the common cause of falling in 30 (57.7) injured cases. Nearly 70 (n = 36) of the cases were transferred to the trauma center by the emergency services. Among injured patients, 4 patients (7.7) died. Overweight patients had a 7.75-fold higher chance of death or handicap compared to underweight patients (P = 0.09). Conclusion: Most of the cases were young men from rural areas who were economically important groups. High air temperature in mid-day time is in related to increase in the probability of falling; thus, it should be advised not to work at this time. A considerable proportion of injured patients were carried by family members to the hospital. Therefore, the general awareness that an injured person must be transferred to the hospital by the emergency medical services for the reduction of the severity of trauma is necessary

Neck and Back Pain Prevalence in Workers of Iranian Steel industries at 2015

Work related musculoskeletal disorders (WMSDs) are considered as the main cause of occupational complications and disability in developing countries. In Iranian steel companies, workers commonly are directly involved in the production process and physical activities such as manual material handling and awkward postures. Present study was performed for assessment of neck and back pain prevalence among workers of four Iranian steel industries. Study participants in our cross sectional study, were randomly selected from workers of four Iranian steel industries. Data of neck and back pain were gathered by Nordic questionnaire. Logistic regression was used for controlling confounding variables and determining independent predictors of neck and back pain among study workers. Among study workers, prevalence of neck and back pain in a recent year were 18.40% and 13.90% respectively. Age (p≤0.02) and job experience (p≤0.00) had significant association with neck pain. Age, sex, BMI, and job duration were not known as an independent predictor of neck or back pain. Neck and back pain prevalence in steel industries were happened whit higher rate compared to most of other countries. Next studies will suggest for determining work related risk factors of WMSDs in workers and designing preventive strategies

Antileishmanial potentials of azacitidine and along with meglumine antimoniate on Leishmania major: In silico prediction and in vitro analysis.

This study aimed to investigate the in vitro and in silico antileishmanial activity of azacitidine (AZA) on Leishmania major promastigotes and amastigotes. The in silico method was used to evaluate the possibility of the interaction of AZA into the binding pocket of inducible nitric oxide synthase (iNOS), a leading defensive oxidative metabolite. Following that, in vitro anti-promastigote, and anti-amastigote activity of AZA was determined using an MTT assay and a macrophage model, respectively. Cytotoxic effects of AZA and meglumine antimoniate (MA) were also assessed by MTT assay on murine macrophages. All experiments were performed in triplicate. The results showed that AZA interacted with Ser133, Gln134, and Lys13 amino acids of iNOS, and the molecular docking score was obtained at -241.053 kcal/mol. AZA in combination with MA significantly (P<0.001) inhibited the growth rate of nonclinical promastigote (IC50 247.6±7.3 μM) and 8.5-fold higher of clinical intramacrophage amastigote stage (29.8±5.3 μM), compared to the untreated group. A significant upsurge of Th1 subsets and transcription genes and a meaningful decline in Th2 cytokines subclasses at the equivalent concentrations of AZA and MA was observed (P<0.001). The apoptosis effect of AZA along with MA was significantly induced on L. major in a dose-dependent manner (P<0.001). The present study demonstrated that AZA possesses antileishmanial activity in in vitro and in silico models. However, AZA combined with MA was more effective than AZA alone in inhibiting the growth rate of promastigotes and amastigotes of L. major. This study indicates that AZA in combination with MA demonstrated a potent antileishmanial mechanism, promoting immune response and enhancing an immunomodulatory role toward the Th1 pathway. This experimental study is a basic study for applying more knowledge about the mechanisms of AZA along with MA in animal models in the future