A pooled-analysis of age and sex based coronary artery calcium scores percentiles

Funding The authors of this publication did not receive any grant from funding agencies in the public, commercial, or not-for-profit sector to support this research effort. Dr. Paolo Raggi was supported by a grant (RES0016825) from the Faculty of Medicine and Dentistry at the University of Alberta, Edmonton, AB, Canada. Dr. Matthew J. Budoff has Grant support from general electric and NIH. None of the other authors declares a conflict of interest. Publisher Copyright: © 2020 [The Author/The Authors]Background: Age and sex based coronary artery calcium score (CAC) percentiles have been used to improve coronary artery disease (CAD) risk prediction. However, the main limitation of the CACs percentiles currently in use is that they are often based on single studies. We performed a pooled analysis of all available studies that reported on CAC percentiles, in order to develop more generalizable age and sex nomograms. Methods: PubMed/Medline and Embase were searched for studies that reported nomograms of age and sex-based CACs percentiles. Studies were included if they reported data collected among asymptomatic individuals without a history of cardiovascular disease. Absolute CACs for each specific percentile stratum were pooled and new percentiles were generated taking into account the sample size of the study. Results: We found 831 studies, of which 12 met the inclusion criteria. Data on CACs percentiles of 134,336 Western and 33,488 Asians were pooled separately, rendering a weighted CACs percentile nomogram available at https://www.calciumscorecalculator.com. Our weighted percentiles differed by up to 24% from the nomograms in use today. Conclusions: Our pooled age and sex based CACs percentiles based on over 155,000 individuals should provide a measure of risk that is more applicable to a wider population than the ones currently in use and hopefully will lead to better risk assessment and treatment decisions.Peer reviewe