2 research outputs found
From ligand to complexes: Part 2: Remarks on human immunodeficiency virus type 1 integrase inhibition by beta-diketo acid metal complexes
In a previous work we reported results about the coordination ability of the diketo acid
pharmacophore, and discussed on the anti-HIV-1 IN activity of a series of synthesized β-diketo
acid metal complexes.
Herein, a further extension of this study is reported. In particular, a new set of complexes with
different stoichiometry was synthesized, and a series of potentiometric measurements were
conducted for two diketo acids as model ligands in the presence of other divalent metal ions in
order to outline a speciation model. The first X-ray solved structure of a diketo acid metal
complex is presented.
Moreover, we tested the obtained complexes for anti-HIV 1 IN activity. Furthermore, detailed
docking studies were conducted in order to investigate the mode of binding of the free ligands
compared with their metal complexes on the active site