Association of intraosseous and intravenous access with patient outcome in out-of-hospital cardiac arrest

Here we report the results of a study on the association between drug delivery via intravenous route or intraosseous route in out-of-hospital cardiac arrest. Intraosseous drug delivery is considered an alternative option in resuscitation if intravenous access is difficult or impossible. Intraosseous uptake of drugs may, however, be compromised. We have performed a retrospective cohort study of all Danish patients with out-of-hospital cardiac arrest in the years 2016-2020 to investigate whether mortality is associated with the route of drug delivery. Outcome was 30-day mortality, death at the scene, no prehospital return of spontaneous circulation, and 7- and 90-days mortality. 17,250 patients had out-of-hospital cardiac arrest. 6243 patients received no treatment and were excluded. 1908 patients had sustained return of spontaneous circulation before access to the vascular bed was obtained. 2061 patients were unidentified, and 286 cases were erroneously registered. Thus, this report consist of results from 6752 patients. Drug delivery by intraosseous route is associated with increased OR of: No spontaneous circulation at any time (OR 1.51), Death at 7 days (OR 1.94), 30 days (2.02), and 90 days (OR 2.29). Intraosseous drug delivery in out-of-hospital cardiac arrest is associated with overall poorer outcomes than intravenous drug delivery.</p

Education trajectories and malpractice complaints—A study among Danish general practitioners

Malpractice litigation is an increasing concern in general practice and other healthcare services but possibly is susceptible to changes in education schemes. In this study using Danish register data, we aimed to investigate the association between general practitioners’ risk of becoming involved in a malpractice complaint in a 1-year time frame and their educational trajectory. Greater age at graduation was associated with increased odds of later complaints, but decreased odds of complaints leading to critique by a disciplinary board. In addition, the time following specialisation, in particular, was associated with increased odds of complaints. Complaint occurrence appeared unrelated to place of education. These findings suggest that, from the point of view of complaints, attention may reasonably be drawn to the significance of medical education and continuing professional development