Magnetoelastic Properties of Hitperm-Type Alloys from Torque Moment

The following paper presents the results of the investigation on the influence of the torque on the magnetic characteristics of the Hitperm-type Fe 41.5 Co 41.5 Cu 1 Nb 3 B 13 alloy, in as-quenched and nanocrystalline state. The methodology of application of the torque to the ring-shaped core is also described. This methodology gives a possibility of achieving uniform shearing stresses in the core. The results indicate that shearing stress sensitivity of Hitperm-type alloys depends on the annealing and nanocrystallization process. This effect should be considered during the development of magnetoelastic torque sensors

Glioblastoma-derived spheroid cultures as an experimental model for analysis of EGFR anomalies

Glioblastoma cell cultures in vitro are frequently used for investigations on the biology of tumors or new therapeutic approaches. Recent reports have emphasized the importance of cell culture type for maintenance of tumor original features. Nevertheless, the ability of GBM cells to preserve EGFR overdosage in vitro remains controversial. Our experimental approach was based on quantitative analysis of EGFR gene dosage in vitro both at DNA and mRNA level. Real-time PCR data were verified with a FISH method allowing for a distinction between EGFR amplification and polysomy 7. We demonstrated that EGFR amplification accompanied by EGFRwt overexpression was maintained in spheroids, but these phenomena were gradually lost in adherent culture. We noticed a rapid decrease of EGFR overdosage already at the initial stage of cell culture establishment. In contrast to EGFR amplification, the maintenance of polysomy 7 resulted in EGFR locus gain and stabilization even in long-term adherent culture in serum presence. Surprisingly, the EGFRwt expression pattern did not reflect the latter phenomenon and we observed no overexpression of the tested gene. Moreover, quantitative analysis demonstrated that expression of the truncated variant of receptor—EGFRvIII was preserved in GBM-derived spheroids at a level comparable to the initial tumor tissue. Our findings are especially important in the light of research using glioblastoma culture as the experimental model for testing novel EGFR-targeted therapeutics in vitro, with special emphasis on the most common mutated form of receptor—EGFRvIII

THE POSSIBILITY OF APPLYING Ni-Zn FERRITES AS SENSORS FOR MEASURING COMPRESSIVE STRESSES

Des senseurs pour mesurer des contraintes de compression, jusqu'à 100 MPa, ont été construits et testés. Ces senseurs étaient construits à partir de quatre sortes de ferrites Ni-Zn. Les caractéristiques de sortie , le domaine d'utilisation et la sensibilité sont présentés.The sensors for measuring compressive stresses, within the range of stresses up to 100 MPa, have been constructed and tested. The sensors were made from four types of Ni-Zn ferrites . The output characteristics, operational range and sensitivity of the sensors are presented

Fem model of permanent magnet vernier motor

Two-dimensional Finite Element analysis and parameterized model of Permanent Magnet Vernier Motor is presented in this paper. The model allows to obtain magnetic flux distribution in the core and air gap and calculate electromagnetic torque. Influence of geometrical parameters and material properties on produced torque could be researched by means of presented model