23 research outputs found
Methodological considerations in the design of trials for safety assessment of new drugs and chemical entities
Testosterone modulates cardiac contraction and calcium homeostasis: cellular and molecular mechanisms
Effect of Degarelix, a Gonadotropin-Releasing Hormone Receptor Antagonist for the Treatment of Prostate Cancer, on Cardiac Repolarisation in a Randomised, Placebo and Active Comparator Controlled Thorough QT/QTc Trial in Healthy Men
Comparison of Sum Absolute QRST Integral, and Temporal Variability in Depolarization and Repolarization, Measured by Dynamic Vectorcardiography Approach, in Healthy Men and Women
Étude morphologique de la fosse ovale et bases anatomiques du cathétérisme transseptal
Prevalence and Risk Factors of Drug-Associated Corrected QT Prolongation in Elderly Hospitalized Patients: Results of a Retrospective Analysis of Data Obtained Over 6Â Months
Gender differences in stability of the instantaneous patterns of body surface potentials during ventricular repolarisation
Women have a higher risk of developing torsade de pointes under QT-prolonging conditions. The electrophysiological differences between the sexes that could account for this are largely unknown. The objective of the work was to evaluate gender differences in repolarisation potentials using a method that is independent of the specific electrical properties of the thorax. 1410 normal recordings from the Glasgow 12-lead ECG database and 52 normal ECG maps obtained separately in Milan were analysed. The average difference between 1 and the correlation coefficient of the instantaneous pattern at the peak of T with that at every other instant is called the early repolarisation deviation index (ERDI) for J-T peak and the late repolarisation deviation index (LRDI) for T peak-T end. In standard ECG recordings, the ERDI was 0.42±0.22 in females compared with 0.19±0.16 in males (p<10−6). The LRDI was higher in males under the age of 50. In body surface maps, the ERDI was 0.32±0.21 in females against 0.16±0.17 in males (p<0.01), and the LRDI was non-significantly higher in males. The pattern of instantaneous body surface potentials showed gender differences during repolarisation with a method that is independent of the electrical properties of the thorax