Inbreeding Depression in Anthropometric Traits Among Telaga Boys of Kharagpur, West Bengal, India

Inbreeding depression in phenotypic variations as well as reproductive capacity was reported in animals. Depression of physical measurements in human beings especially among infants and adults due to inbreeding has also been reported all over the world. The present study is an attempt to examine the nature of inbreeding effect on growing children at each yearly age with increase of inbreeding intensity in a local endogamous population based on pedigree data. In general, mean values of measurements appear to be smaller in higher levels of inbreeding from that of lower levels of inbreeding in each yearly age. These differences are even more marked when grouped as low and high inbreeding level. The percent of inbreeding depression tends to be larger in post adolescent boys than in younger children

Inbreeding Depression in Anthropometric Traits Among Telaga Boys of Kharagpur, West Bengal, India

Inbreeding depression in phenotypic variations as well as reproductive capacity was reported in animals. Depression of physical measurements in human beings especially among infants and adults due to inbreeding has also been reported all over the world. The present study is an attempt to examine the nature of inbreeding effect on growing children at each yearly age with increase of inbreeding intensity in a local endogamous population based on pedigree data. In general, mean values of measurements appear to be smaller in higher levels of inbreeding from that of lower levels of inbreeding in each yearly age. These differences are even more marked when grouped as low and high inbreeding level. The percent of inbreeding depression tends to be larger in post adolescent boys than in younger children

Duct-to-mucosa pancreatojejunostomy is a safe technique of reconstruction after pancreatoduodenectomy

Background: A duct-to-mucosa pancreatojejunostomy is technically difficult to perform than Dunking procedure after pancreatoduodenectomy. In contrast, the incidence of anastomotic dehiscence is more in Dunking than duct-to-mucosa procedure. Duct-to-mucosa technique is rarely practiced in our country because of technical difficulties and lack of experiences. Objectives: This study was undertaken to evaluate the safety of duct-to-mucosa procedure in our patients with pancreatoduodenectomy. Methods: We have performed pancreatojejunostomy in 14 consecutive patients using a duct-to-mucosa technique and the result was assessed. Results: No patients developed pancreato-jejunal leakage; however, 6 of 14 patients developed complications not related to operative techniques (wound infections; 3,jejunal fistula following removal of jejunal feeding tube; 1, renal dysfunction; 1, delayed gastric emptying; 1) which were managed conservatively. There were no postoperative deaths in the present series and the median postoperative hospital stay was 20.3 days. The follow-up period ranged from 1 to 12 months and all patients are surviving with good health during this period. Conclusion: Pancreatojejunostomy by duct-to-mucosal technique is a safe method of pancreatojejunostomy after pancreatoduodenecytomy

Change in serum interleukin-6 levels in patients after pancreatoduodenectomy for periampullary cancer

This study was undertaken to elucidate the changes in interleukin-6 concentrations in the systemic circulation of 20 patients following pancreatoduodenectomy and whether it had any predictive value for postoperative complications. Blood was drawn on the day before surgery, at fixed intervals immediately after closure of the abdomen, and on day 1, 3, 5 after surgery for the measurement of interleukin-6. Change in the serum interleukin-6 levels was observed before and after pancreatoduodenectomy and between patients with and without complications. There was no mortality, but morbidity occurred in 5 patients. Serum interleukin-6 levels peaked immediately after surgery and gradually declined to preoperative level on postoperative day 5, but it remained persistently higher in a patient who developed postoperative complication. The peak level of interleukin-6 was significantly correlated with body mass index, duration of jaundice, biliary decompression prior to surgery, operation time and hospital stay, but not with operative blood loss. In conclusion, interleukin-6 is an important stress marker for predicting the complications after pancreatoduodenectomy operation. Patient with good body mass index status, short duration of jaundice and without preoperative biliary decompression provides less operative stress, less chance of complications and shorter hospital stay

Whole-Genome Sequence of Drug-Resistant Mycobacterium tuberculosis Strain S7, Isolated from a Patient with Pulmonary Tuberculosis

Over the past decades, drug-resistant Mycobacterium tuberculosis strains have presented a significant challenge, with inadequate diagnosis of tuberculosis (TB) cases. Here, we report the draft whole-genome sequence of drug-resistant M. tuberculosis strain S7, which was isolated from a patient from Tripura, India, who was diagnosed with pulmonary TB