Eukaryotic initiation factor-4E in superficial and muscle invasive bladder cancer and its correlation with vascular endothelial growth factor expression and tumour progression

Vascular endothelial growth factor (VEGF) is an important factor mediating tumour angiogenesis. VEGF mRNA is differentially expressed in bladder cancer with high expression in superficial tumours (stage pTaand pT1) contrasting with low expression in muscle invasive tumours (stage ≥ pT2). To investigate mechanisms regulating VEGF expression in bladder cancer, VEGF mRNA and protein were measured in normal bladder (n = 12) and primary bladder cancers (n = 57). VEGF protein levels correlated with mRNA expression in normal bladder (r = 0.68, P = 0.02) and bladder cancer (r = 0.46, P = 0.0007). Whilst VEGF mRNA expression was threefold higher in superficial compared to muscle invasive bladder cancers (P = 0.0001) there was no difference in VEGF protein (P = 0.81). Accordingly, the median protein:mRNA ratios increased more than 15-fold with increasing tumour stage (P< 0.0001) suggesting translational regulation. Expression of the eukaryotic initiation factor-4E (eIF-4E), a factor implicated in the translational regulation of VEGF, was greater in tumours than normal bladder (P< 0.0001) and correlated with VEGF protein:mRNA ratios (n = 43, r = 0.54, P = 0.0004) pointing to its role in the regulation of VEGF. In superficial tumours (n = 37) high expression of eIF-4E was associated with a poor prognosis and reduced stage progression-free survival (P = 0.04, Cox proportional hazards model). The study demonstrates that eIF-4E may be involved in translational regulation of VEGF in bladder cancer and might have a role as a prognostic factor in bladder cancer. © 2000 Cancer Research Campaig

The Twin-Jet of NGC1052 at Radio, Optical, and X-ray Frequencies

We present results from a combined radio, optical, and X-ray study of the jet-associated emission features in NGC1052. We analyse the radio-optical morphology and find a good positional correlation between the radio jet and the optical emission cone. Two optical emission knots are directly associated with radio counterparts exhibiting a radio to X-ray broadband spectrum not compatible with synchrotron emission. We discuss the possibility that the thermal soft spectrum of the extended X-ray emission originates from jet driven shocks produced in the interaction between the jet-plasma and its surrounding medium.Comment: 4 pages, 1 figure, needs elsart.cls, to be published in ''The Physics of Relativistic Jets in the CHANDRA and XMM Era'', G. Brunetti, D.E. Harris, R.M. Sambruna, G. Setti (eds.

Equation of state and transport processes in self--similar spheres

We study the effect of transport processes (diffusion and free--streaming) on a collapsing spherically symmetric distribution of matter in a self--similar space--time. A very simple solution shows interesting features when it is matched with the Vaidya exterior solution. In the mixed case (diffusion and free--streaming), we find a barotropic equation of state in the stationary regime. In the diffusion approximation the gravitational potential at the surface is always constant; if we perturb the stationary state, the system is very stable, recovering the barotropic equation of state as time progresses. In the free--streaming case the self--similar evolution is stationary but with a non--barotropic equation of state.Comment: 9 pages, 2 figure

Discovery of an X-ray Jet and Extended Jet Structure in the Quasar PKS 1055+201

This letter reports rich X-ray jet structures found in the Chandra observation of PKS 1055+201. In addition to an X-ray jet coincident with the radio jet we detect a region of extended X-ray emission surrounding the jet as far from the core as the radio hotspot to the North, and a similar extended X-ray region along the presumed path of the unseen counterjet to the Southern radio lobe. Both X-ray regions show a similar curvature to the west, relative to the quasar. We interpret this as the first example where we separately detect the X-ray emission from a narrow jet and extended, residual jet plasma over the entire length of a powerful FRII jet.Comment: Accepted for publication in Ap. J. Letters. 4 pages, 3 figure

A Multi-Wavelength Study of the Jet, Lobes and Core of the Quasar PKS 2101-490

We present a detailed study of the X-ray, optical and radio emission from the jet, lobes and core of the quasar PKS 2101-490 as revealed by new Chandra, HST and ATCA images. We extract the radio to X-ray spectral energy distributions from seven regions of the 13 arcsecond jet, and model the jet X-ray emission in terms of Doppler beamed inverse Compton scattering of the cosmic microwave background (IC/CMB) for a jet in a state of equipartition between particle and magnetic field energy densities. This model implies that the jet remains highly relativistic hundreds of kpc from the nucleus, with a bulk Lorentz factor Gamma ~ 6 and magnetic field of order 30 microGauss. We detect an apparent radiative cooling break in the synchrotron spectrum of one of the jet knots, and are able to interpret this in terms of a standard one-zone continuous injection model, based on jet parameters derived from the IC/CMB model. However, we note apparent substructure in the bright optical knot in one of the HST bands. We confront the IC/CMB model with independent estimates of the jet power, and find that the IC/CMB model jet power is consistent with the independent estimates, provided that the minimum electron Lorentz factor gamma_min > 50, and the knots are significantly longer than the jet width, as implied by de-projection of the observed knot lengths.Comment: 16 pages, 10 figures, 6 table

PKS B1545-321: Bow shocks of a relativistic jet?

Sensitive, high resolution images of the double-double radio galaxy PKS B1545-321 reveal detailed structure, which we interpret in the light of previous work on the interaction of restarted jets with pre-existing relict cocoons. We have also examined the spectral and polarization properties of the source, the color distribution in the optical host and the environment of this galaxy in order to understand its physical evolution. We propose that the restarted jets generate narrow bow shocks and that the inner lobes are a mixture of cocoon plasma reaccelerated at the bow shock and new jet material reaccelerated at the termination shock. The dynamics of the restarted jets implies that their hot spots advance at mildly relativistic speeds with external Mach numbers of at least 5. The existence of supersonic hot spot Mach numbers and bright inner lobes is the result of entrainment causing a reduction in the sound speed of the pre-existing cocoon. The interruption to jet activity in PKS B1545-321 has been brief - lasting less than a few percent of the lifetime $\sim (0.3-2)\times 10^{8} yr$ of the giant radio source. The host galaxy is located at the boundary of a large scale filamentary structure, and shows blue patches in color distribution indicative of a recent merger, which may have triggered the Mpc-scale radio galaxy.Comment: 26 pages including 1 table and 16 figures. To appear in MNRA

Quantum Cosmology and Higher-Order Lagrangian Theories

In this paper the quantum cosmological consequences of introducing a term cubic in the Ricci curvature scalar $R$ into the Einstein--Hilbert action are investigated. It is argued that this term represents a more generic perturbation to the action than the quadratic correction usually considered. A qualitative argument suggests that there exists a region of parameter space in which neither the tunneling nor the no-boundary boundary conditions predict an epoch of inflation that can solve the horizon and flatness problems of the big bang model. This is in contrast to the $R^2$--theory.Comment: 13 pages, LaTeX, preprint FERMILAB-Pub-94/XXX-A, March 199

Kaluza-Klein Higher Derivative Induced Gravity

The existence and stability analysis of an inflationary solution in a $D+4$-dimensional anisotropic induced gravity is presented in this paper. Nontrivial conditions in the field equations are shown to be compatible with a cosmological model in which the 4-dimension external space evolves inflationary, while, the D-dimension internal one is static. In particular, only two additional constraints on the coupling constants are derived from the abundant field equations and perturbation equations. In addition, a compact formula for the non-redundant 4+D dimensional Friedmann equation is also derived for convenience. Possible implications are also discussed in this paper.Comment: 13 pages, typos/errors corrected, three additional appendices adde

Convergence to a self-similar solution in general relativistic gravitational collapse

We study the spherical collapse of a perfect fluid with an equation of state $P=k\rho$ by full general relativistic numerical simulations. For 0, it has been known that there exists a general relativistic counterpart of the Larson-Penston self-similar Newtonian solution. The numerical simulations strongly suggest that, in the neighborhood of the center, generic collapse converges to this solution in an approach to a singularity and that self-similar solutions other than this solution, including a ``critical solution'' in the black hole critical behavior, are relevant only when the parameters which parametrize initial data are fine-tuned. This result is supported by a mode analysis on the pertinent self-similar solutions. Since a naked singularity forms in the general relativistic Larson-Penston solution for 0, this will be the most serious known counterexample against cosmic censorship. It also provides strong evidence for the self-similarity hypothesis in general relativistic gravitational collapse. The direct consequence is that critical phenomena will be observed in the collapse of isothermal gas in Newton gravity, and the critical exponent $\gamma$ will be given by $\gamma\approx 0.11$, though the order parameter cannot be the black hole mass.Comment: 22 pages, 15 figures, accepted for publication in Physical Review D, reference added, typos correcte

A relativistic model of the radio jets in NGC 315

We apply our intrinsically symmetrical, decelerating relativistic jet model to deep VLA imaging of the inner 140 arcsec of the giant low-luminosity radio galaxy NGC 315. An optimized model accurately fits the data in both total intensity and linear polarization. We infer that the velocity, emissivity and field structure in NGC 315 are very similar to those of the other low-luminosity sources we have modelled, but that all of the physical scales are larger by a factor of about 5. We derive an inclination to the line of sight of 38 degrees for the jets. Where they first brighten, their on-axis velocity is approximately v/c = 0.9. They decelerate to v/c = 0.4 between 8 and 18 kpc from the nucleus and the velocity thereafter remains constant. The speed at the edge of the jet is roughly 0.6 of the on-axis value where it is best constrained, but the transverse velocity profile may deviate systematically from the Gaussian form we assume. The proper emissivity profile is split into three power-law regions separated by shorter transition zones. In the first of these, at 3 kpc (the flaring point) the jets expand rapidly at constant emissivity, leading to a large increase in the observed brightness on the approaching side. At 10 kpc, the emissivity drops abruptly by a factor of 2. Where the jets are well resolved their rest-frame emission is centre-brightened. The magnetic field is modelled as random on small scales but anisotropic and we rule out a globally ordered helical configuration. To a first approximation, the field evolves from a mixture of longitudinal and toroidal components to predominantly toroidal, but it also shows variations in structure along and across the jets, with a significant radial component in places. Simple adiabatic models fail to fit the emissivity variations.Comment: 20 pages, 17 figures, MNRAS (in press