636 research outputs found
Eukaryotic initiation factor-4E in superficial and muscle invasive bladder cancer and its correlation with vascular endothelial growth factor expression and tumour progression
Vascular endothelial growth factor (VEGF) is an important factor mediating tumour angiogenesis. VEGF mRNA is differentially expressed in bladder cancer with high expression in superficial tumours (stage pTaand pT1) contrasting with low expression in muscle invasive tumours (stage ≥ pT2). To investigate mechanisms regulating VEGF expression in bladder cancer, VEGF mRNA and protein were measured in normal bladder (n = 12) and primary bladder cancers (n = 57). VEGF protein levels correlated with mRNA expression in normal bladder (r = 0.68, P = 0.02) and bladder cancer (r = 0.46, P = 0.0007). Whilst VEGF mRNA expression was threefold higher in superficial compared to muscle invasive bladder cancers (P = 0.0001) there was no difference in VEGF protein (P = 0.81). Accordingly, the median protein:mRNA ratios increased more than 15-fold with increasing tumour stage (P< 0.0001) suggesting translational regulation. Expression of the eukaryotic initiation factor-4E (eIF-4E), a factor implicated in the translational regulation of VEGF, was greater in tumours than normal bladder (P< 0.0001) and correlated with VEGF protein:mRNA ratios (n = 43, r = 0.54, P = 0.0004) pointing to its role in the regulation of VEGF. In superficial tumours (n = 37) high expression of eIF-4E was associated with a poor prognosis and reduced stage progression-free survival (P = 0.04, Cox proportional hazards model). The study demonstrates that eIF-4E may be involved in translational regulation of VEGF in bladder cancer and might have a role as a prognostic factor in bladder cancer. © 2000 Cancer Research Campaig
The Twin-Jet of NGC1052 at Radio, Optical, and X-ray Frequencies
We present results from a combined radio, optical, and X-ray study of the
jet-associated emission features in NGC1052. We analyse the radio-optical
morphology and find a good positional correlation between the radio jet and the
optical emission cone. Two optical emission knots are directly associated with
radio counterparts exhibiting a radio to X-ray broadband spectrum not
compatible with synchrotron emission. We discuss the possibility that the
thermal soft spectrum of the extended X-ray emission originates from jet driven
shocks produced in the interaction between the jet-plasma and its surrounding
medium.Comment: 4 pages, 1 figure, needs elsart.cls, to be published in ''The Physics
of Relativistic Jets in the CHANDRA and XMM Era'', G. Brunetti, D.E. Harris,
R.M. Sambruna, G. Setti (eds.
Equation of state and transport processes in self--similar spheres
We study the effect of transport processes (diffusion and free--streaming) on
a collapsing spherically symmetric distribution of matter in a self--similar
space--time. A very simple solution shows interesting features when it is
matched with the Vaidya exterior solution. In the mixed case (diffusion and
free--streaming), we find a barotropic equation of state in the stationary
regime. In the diffusion approximation the gravitational potential at the
surface is always constant; if we perturb the stationary state, the system is
very stable, recovering the barotropic equation of state as time progresses. In
the free--streaming case the self--similar evolution is stationary but with a
non--barotropic equation of state.Comment: 9 pages, 2 figure
Discovery of an X-ray Jet and Extended Jet Structure in the Quasar PKS 1055+201
This letter reports rich X-ray jet structures found in the Chandra
observation of PKS 1055+201. In addition to an X-ray jet coincident with the
radio jet we detect a region of extended X-ray emission surrounding the jet as
far from the core as the radio hotspot to the North, and a similar extended
X-ray region along the presumed path of the unseen counterjet to the Southern
radio lobe. Both X-ray regions show a similar curvature to the west, relative
to the quasar. We interpret this as the first example where we separately
detect the X-ray emission from a narrow jet and extended, residual jet plasma
over the entire length of a powerful FRII jet.Comment: Accepted for publication in Ap. J. Letters. 4 pages, 3 figure
A Multi-Wavelength Study of the Jet, Lobes and Core of the Quasar PKS 2101-490
We present a detailed study of the X-ray, optical and radio emission from the
jet, lobes and core of the quasar PKS 2101-490 as revealed by new Chandra, HST
and ATCA images. We extract the radio to X-ray spectral energy distributions
from seven regions of the 13 arcsecond jet, and model the jet X-ray emission in
terms of Doppler beamed inverse Compton scattering of the cosmic microwave
background (IC/CMB) for a jet in a state of equipartition between particle and
magnetic field energy densities. This model implies that the jet remains highly
relativistic hundreds of kpc from the nucleus, with a bulk Lorentz factor Gamma
~ 6 and magnetic field of order 30 microGauss. We detect an apparent radiative
cooling break in the synchrotron spectrum of one of the jet knots, and are able
to interpret this in terms of a standard one-zone continuous injection model,
based on jet parameters derived from the IC/CMB model. However, we note
apparent substructure in the bright optical knot in one of the HST bands. We
confront the IC/CMB model with independent estimates of the jet power, and find
that the IC/CMB model jet power is consistent with the independent estimates,
provided that the minimum electron Lorentz factor gamma_min > 50, and the knots
are significantly longer than the jet width, as implied by de-projection of the
observed knot lengths.Comment: 16 pages, 10 figures, 6 table
PKS B1545-321: Bow shocks of a relativistic jet?
Sensitive, high resolution images of the double-double radio galaxy PKS
B1545-321 reveal detailed structure, which we interpret in the light of
previous work on the interaction of restarted jets with pre-existing relict
cocoons. We have also examined the spectral and polarization properties of the
source, the color distribution in the optical host and the environment of this
galaxy in order to understand its physical evolution. We propose that the
restarted jets generate narrow bow shocks and that the inner lobes are a
mixture of cocoon plasma reaccelerated at the bow shock and new jet material
reaccelerated at the termination shock. The dynamics of the restarted jets
implies that their hot spots advance at mildly relativistic speeds with
external Mach numbers of at least 5. The existence of supersonic hot spot Mach
numbers and bright inner lobes is the result of entrainment causing a reduction
in the sound speed of the pre-existing cocoon. The interruption to jet activity
in PKS B1545-321 has been brief - lasting less than a few percent of the
lifetime of the giant radio source. The host
galaxy is located at the boundary of a large scale filamentary structure, and
shows blue patches in color distribution indicative of a recent merger, which
may have triggered the Mpc-scale radio galaxy.Comment: 26 pages including 1 table and 16 figures. To appear in MNRA
Quantum Cosmology and Higher-Order Lagrangian Theories
In this paper the quantum cosmological consequences of introducing a term
cubic in the Ricci curvature scalar into the Einstein--Hilbert action are
investigated. It is argued that this term represents a more generic
perturbation to the action than the quadratic correction usually considered. A
qualitative argument suggests that there exists a region of parameter space in
which neither the tunneling nor the no-boundary boundary conditions predict an
epoch of inflation that can solve the horizon and flatness problems of the big
bang model. This is in contrast to the --theory.Comment: 13 pages, LaTeX, preprint FERMILAB-Pub-94/XXX-A, March 199
Kaluza-Klein Higher Derivative Induced Gravity
The existence and stability analysis of an inflationary solution in a
-dimensional anisotropic induced gravity is presented in this paper.
Nontrivial conditions in the field equations are shown to be compatible with a
cosmological model in which the 4-dimension external space evolves
inflationary, while, the D-dimension internal one is static. In particular,
only two additional constraints on the coupling constants are derived from the
abundant field equations and perturbation equations. In addition, a compact
formula for the non-redundant 4+D dimensional Friedmann equation is also
derived for convenience. Possible implications are also discussed in this
paper.Comment: 13 pages, typos/errors corrected, three additional appendices adde
Convergence to a self-similar solution in general relativistic gravitational collapse
We study the spherical collapse of a perfect fluid with an equation of state
by full general relativistic numerical simulations. For 0, it has been known that there exists a general relativistic counterpart
of the Larson-Penston self-similar Newtonian solution. The numerical
simulations strongly suggest that, in the neighborhood of the center, generic
collapse converges to this solution in an approach to a singularity and that
self-similar solutions other than this solution, including a ``critical
solution'' in the black hole critical behavior, are relevant only when the
parameters which parametrize initial data are fine-tuned. This result is
supported by a mode analysis on the pertinent self-similar solutions. Since a
naked singularity forms in the general relativistic Larson-Penston solution for
0, this will be the most serious known counterexample against
cosmic censorship. It also provides strong evidence for the self-similarity
hypothesis in general relativistic gravitational collapse. The direct
consequence is that critical phenomena will be observed in the collapse of
isothermal gas in Newton gravity, and the critical exponent will be
given by , though the order parameter cannot be the black
hole mass.Comment: 22 pages, 15 figures, accepted for publication in Physical Review D,
reference added, typos correcte
A relativistic model of the radio jets in NGC 315
We apply our intrinsically symmetrical, decelerating relativistic jet model
to deep VLA imaging of the inner 140 arcsec of the giant low-luminosity radio
galaxy NGC 315. An optimized model accurately fits the data in both total
intensity and linear polarization. We infer that the velocity, emissivity and
field structure in NGC 315 are very similar to those of the other
low-luminosity sources we have modelled, but that all of the physical scales
are larger by a factor of about 5. We derive an inclination to the line of
sight of 38 degrees for the jets. Where they first brighten, their on-axis
velocity is approximately v/c = 0.9. They decelerate to v/c = 0.4 between 8 and
18 kpc from the nucleus and the velocity thereafter remains constant. The speed
at the edge of the jet is roughly 0.6 of the on-axis value where it is best
constrained, but the transverse velocity profile may deviate systematically
from the Gaussian form we assume. The proper emissivity profile is split into
three power-law regions separated by shorter transition zones. In the first of
these, at 3 kpc (the flaring point) the jets expand rapidly at constant
emissivity, leading to a large increase in the observed brightness on the
approaching side. At 10 kpc, the emissivity drops abruptly by a factor of 2.
Where the jets are well resolved their rest-frame emission is
centre-brightened. The magnetic field is modelled as random on small scales but
anisotropic and we rule out a globally ordered helical configuration. To a
first approximation, the field evolves from a mixture of longitudinal and
toroidal components to predominantly toroidal, but it also shows variations in
structure along and across the jets, with a significant radial component in
places. Simple adiabatic models fail to fit the emissivity variations.Comment: 20 pages, 17 figures, MNRAS (in press
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